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The application of machine learning techniques for monitoring and diagnosing faults in photovoltaic (PV) systems has been shown to enhance the reliability of PV power generation. This research introduced a novel machine learning classifier for fault diagnosis in PV systems, utilizing an ensemble algorithm known as extra trees (ETC). The study initially proposed a system with two PV modules and developed a low-cost Arduino-based data logger to gather data from the PV system in free-fault and faulty conditions. Subsequently, the study evaluated six other advanced classifiers for fault diagnosis in PV systems, namely logistic regression (LR), k-nearest neighbor (kNN), support vector machine (SVM), decision tree (DT), AdaBoost, and random forest (RF) models using the collected data from the proposed PV system. The assessment of the various models' performance indicated that the extra trees model exhibits superior classification capabilities for partial shading (PS), open circuit (OCF), partial shading with bypass diode disconnected (PSBD), and combined partial shading with bypass diode disconnected plus open circuit (PSBDOC) faults. The results demonstrated that the new ETC classifier achieves an accuracy of 92%, surpassing the 91%, 87%, 7%, and 59% accuracy of the RF, DT, kNN, and LR classifiers, respectively. This highlights the effectiveness of the extra trees model in enhancing fault detection and classification by distinguishing between open circuits and twin faults. Consequently, these results can be utilized to develop advanced diagnostic tools for photovoltaic systems, thereby improving the reliability of solar technology and accelerating the rate of installation.

Objective: To determine maternal and neonatal complications occurring at childbirth among adolescents. Materials and methods: This is a retrospective, descriptive study conducted from 1st July to 31st December 2019 at the maternity ward of the Sylvanus Olympio University Hospital Centre (CHU- SO), Lomé, Togo. The socio- demographic parameters of the mothers, details of prenatal and perinatal events and the clinical profile of the newborns at birth were studied. Results: The records of 332 adolescent mothers were studied. The average age of the mothers was 17.4 ± 1.5 years, with a range of 13-19 years. The pregnancies in two-thirds (66.3%) were supervised in centres without surgical facilities and by midwives in 83.1% of cases. A little over half of the mothers (53.3%) attended at least four antenatal clinic sessions, while 3.6% attended none. The modes of delivery were spontaneous vaginal (62.3%) and Caesarean section (35.2%). Complications of pregnancy were recorded in 12.9% of the mothers. There were statistically significant associations between the referred status of the mothers and haemorrhages, retained placenta and sepsis (p = 0.001, 0.038 and 0.011, respectively). There were no maternal deaths. The newborn babies required resuscitation in 6.3% of cases, while 7.0% were stillborn. There was a statistically significant relationship between the referred status of mothers and the occurrence of perinatal deaths (p = 0.0001). Conclusion: Adolescent mothers are at risk of complications during childbirth, and these risks are increased by poor antenatal care and attempted deliveries in centres without surgical facilities.

We present in this article the complete setup to build a triggered controller with a mechanical optical shutter. The system is a low cost, Do-It-Yourself, and easy to implement setup with three functionalities: Manual mode, direct mode with TTL signal command and Triggered mode with a TTL signal command. Our setup is primarily intended to be integrated in optical setup where one needs to control the opening time of a light path, but can be used also for any other setup where one wants to send a TTL signal to command another subsystem (in our case the shutter is that subsystem). The shutter used here is hard disk drive voice-coil actuator, which was already demonstrated to have interesting potentialities to be a mechanical shutter.In the Manual mode, this setup achieves an opening and closing time of 3 ms. In Direct mode with TTL signal command, the setup has a delay response time of 19 ms and a minimum open pulse time of 23 ms. This low cost device which can be made with less than 50€, have similar characteristics with commercial ones which can be twenty times more expensive.

Abstract This article delves into the intriguing realm of food waste valorization conducted by nongovernmental organizations (NGOs) in two distinct locales—Brasilia, Brazil, and Lomé, Togo. The primary focus of this exploration is the lens of the Circular Economy (CE), a concept that emphasizes the sustainable utilization of resources within closed loops. The discourse is further enriched by introducing the notion of upcycling, a complementary force to the Circular Economy, particularly within the intricate web of food supply chains. The ReSOLVE framework, a strategic approach for managing food waste, is a guiding light in this research. Upon dissecting the outcomes, noteworthy limitations come to the forefront, shedding light on the challenges of aligning NGOs from both countries with the principles of the Circular Economy in their food waste management endeavors. These challenges assume heightened significance against the backdrop of the intricate global food security landscape, effectively underlining the intricacies of harmonizing the Circular Economy's ambitions with the pragmatic goal of diminishing food waste. The overarching objective of this study is to galvanize circular-oriented initiatives that can effectively curtail and prevent food wastage on a global scale, with a particular emphasis on developing nations. This pursuit is underscored by the triad of benefits such initiatives confer: economic advancement, social amelioration, and a positive ecological footprint. In an era where sustainability stands as a paramount concern, this research advocates for concerted efforts to harmonize the noble ideals of the Circular Economy with the pressing need for food waste reduction, especially within regions striving for holistic growth and development.

BackgroundThere is a growing body of evidence that asserts community engagement approaches can improve the quality of reproductive health services. Family planning (FP) programs in Togo are implementing such approaches, which aim to mobilize both health workers and communities to improve FP service quality and FP uptake. However, there is not enough known about the enabling factors and challenges associated with implementation, or the extent to which the programs improve outcomes leading to contraceptive uptake.MethodsWe qualitatively explored how a community engagement approach influenced health worker and community perceptions related to FP service delivery in and around the city of Lomé, Togo, within the context of the broader integration of social and behavior change and service delivery. We conducted 18 in-depth interviews with health workers and 9 focus group discussions with community members.ResultsWe found the approach, which included community dialogues, site walkthrough visits and the development of community action plans, worked synergistically together to support collaborative action between communities and health workers to increase mutual understanding of their collective needs related to FP services. Community members cited improved reception at the health facilities by health workers and indicated that the site walkthrough visits created a greater sense of empathy towards the providers and the challenges faced in their work environment. Health workers acknowledged a greater understanding of barriers at the community level following community dialogues, particularly among community members that are not routinely encountered at the health facility for reproductive health services such as men and youth. We found limited implementation of health facility improvements included in community action plans because they were dependent on commitment from community leadership and the need to mobilize additional support or financial resources.ConclusionCommunity engagement approaches are a promising mechanism to support collaboration and enhance mutual understanding between health workers and communities to achieve improved FP service quality. Future programs should consider incorporating additional mechanisms to monitor community action plans and provide support to address structural challenges at the facility level particularly those that require financial resources.

Background: Cerebral small vessel disease is the most common cause of lacunar strokes (LS). Understanding LS pathogenesis is vital for predicting disease severity, prognosis, and developing therapies. Objectives: To research molecular profiles that differentiate LS in deep brain structures from those in subcortical white matter. Design: Prospective case–control study involving 120 patients with imaging-confirmed LS and a 120 control group. Methods: We examined the relationship between Alzheimer’s disease biomarkers [amyloid beta (Aβ 1–40 , Aβ 1–42 )], serum inflammatory marker (interleukin-6, IL-6), and endothelial dysfunction markers [soluble tumor necrosis factor-like weak inducer of apoptosis, and pentraxin-3 (sTWEAK, PTX3)] with respect to LS occurring in deep brain structures and subcortical white matter. In addition, we investigated links between LS, leukoaraiosis presence (white matter hyperintensities, WMHs), and functional outcomes at 3 months. Poor outcome was defined as a modified Rankin scale >2 at 3 months. Results: Significant differences were observed in levels of IL-6, PTX3, and sTWEAK between patients with deep lacunar infarcts and those with recent small subcortical infarcts (20.8 versus 15.6 pg/mL, p

During routine virus screening, grapevine red blotch virus (GRBV; genus Grablovirus, family Geminiviridae) was detected in several samples of a recently released interspecific hybrid wine grapevine cultivar, Blanc du Soleil (BdS, US PP 34,483 P2, 2022). Molecular characterization of the BdS GRBV isolates revealed the presence of distinct complete genomes in nine isolates, with atypical lengths of 3,181 to 3,183 nucleotides (nt) relative to the expected 3,205 to 3,208 nt reported for GRBV isolates characterized to date globally. The difference in length was mainly due to deletions in the long intergenic region of the BdS GRBV isolates. In a phylogenetic reconstruction, the BdS GRBV isolates formed a monophyletic subclade basal to the clade II isolates to which they were more phylogenetically related than the clade I isolates. On average, complete genomes of these new isolates are 98.75% identical to each other, 96.66% identical to clade II isolates, and 92.02% identical to clade I isolates. Evolutionary analysis also revealed the occurrence of recombination in the history of these new isolates. [Figure: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.

Biochemistry, hematology and serology laboratories produce very heterogeneous discharges capable of polluting water, soil and the environment. The aim of this study is to evaluate the physico-chemical quality of the ashes, effluents and the range of equipment that produce the much effluent and pollutions.This is a descriptive and cross-sectional study of 82 laboratories followed by the sampling of effluents from automatons. The physico-chemical parameters and trace elements are determined according to French Standardization Association (AFNOR) standards and used atomic absorption spectrometers and molecular absorption spectrometers. The Mindray hematology automaton is used for 64.7% and 81.5% of the cans are used to collect waste. Semehow 77.8% of discharges are released into sinks without adequate treatment in 42.6% of cases. Chemical analyses show that trace elements (TE) levels in effluents range from 5.89 ± 0.21 to 105.80 ± 0.96 μg/L for Arsenic; from 5.62 ± 0.34 to 6.53 ± 0.49 μg/L for Cadmium; 0.70 ± 0.01 to 10.63 ± 1.17 μg/L for Mercure and 35.72 ± 1.88 to 61.98 ± 5.15 μg/L for Plomb. pH ranges from 7.17 ± 0.65 to 8.3 ± 1.35 with total dissolved salts (TDS) range from 3260.20 ± 401.68 to 17117.41 ± 265.37 mg/L. All averages of contamination indices (CI) and polymetallic contamination indices (PCI) for post-incineration ashes are greater than 1.5 with the exception of Hg (0.22). For effluents, in addition to polymetallic contamination indices (PCI), CI in hematology effluents (1.09), all CI are less than 1. Hematology effluents have a lower pH and are much more mineralized and concentrated in trace elements while those from biochemistry and serology appear to be similar. However, the effluents of Biochemistry and Serology are more basic and concentrated in Suspended Solids with higher values obtained in Biochemistry. Although the physico-chemical parameters comply with WHO standards, discharges from automatons deserve appropriate treatment before their disposal.

Background: Monogenic Alzheimer’s disease (AD) has severe health and socioeconomic repercussions. Its rarest cause is presenilin 2 (PSEN2) gene mutations. We present two new cases with presumed PSEN2-AD with unusual clinical and neuroimaging findings in order to provide more information on the pathophysiology and semiology of these patients. Methods: Women aged 69 and 62 years at clinical onset, marked by prominent behavioral and language dysfunction, progressing to severe dementia within three years were included. The complete study is depicted. In addition, a systematic review of the PSEN2-AD was performed. Results: Neuroimaging revealed pronounced frontal white matter hyperintensities (WMH) and frontotemporal atrophy/hypometabolism. The genetic study unveiled PSEN2 variants: c.772G>A (p.Ala258Thr) and c.1073-2_1073-1del. Both cerebrospinal fluid (CSF) and experimental blood biomarkers shouldered AD etiology. Conclusions: Prominent behavioral and language dysfunction suggesting frontotemporal dementia (FTD) may be underestimated in the literature as a clinical picture in PSEN2 mutations. Thus, it may be reasonable to include PSEN2 in genetic panels when suspecting FTDL. PSEN2 mutations may cause striking WMH, arguably related to myelin disruption induced by amyloid accumulation.

Glutamate grabbers, such as glutamate oxaloacetate transaminase (GOT), have been proposed to prevent excitotoxicity secondary to high glutamate levels in stroke patients. However, the efficacy of blood glutamate grabbing by GOT could be dependent on the extent and severity of the disruption of the blood–brain barrier (BBB). Our purpose was to analyze the relationship between GOT and glutamate concentration with the patient’s functional status differentially according to BBB serum markers (soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and leukoaraiosis based on neuroimaging). This retrospective observational study includes 906 ischemic stroke patients. We studied the presence of leukoaraiosis and the serum levels of glutamate, GOT, and sTWEAK in blood samples. Functional outcome was assessed using the modified Rankin Scale (mRS) at 3 months. A significant negative correlation between GOT and glutamate levels at admission was shown in those patients with sTWEAK levels > 2900 pg/mL (Pearson’s correlation coefficient: −0.249; p < 0.0001). This correlation was also observed in patients with and without leukoaraiosis (Pearson’s correlation coefficients: −0.299; p < 0.001 vs. −0.116; p = 0.024). The logistic regression model confirmed the association of higher levels of GOT with lower odds of poor outcome at 3 months when sTWEAK levels were >2900 pg/mL (OR: 0.41; CI 95%: 0.28–0.68; p < 0.0001) or with leukoaraiosis (OR: 0.75; CI 95%: 0.69–0.82; p < 0.0001). GOT levels are associated with glutamate levels and functional outcomes at 3 months, but only in those patients with leukoaraiosis and elevated sTWEAK levels. Consequently, therapies targeting glutamate grabbing might be more effective in patients with BBB dysfunction.

Hydropower is a traditional and widespread form of renewable energy and vertical axis turbines are an emerging technology suitable for low to medium velocity water bodies such as rivers. Such devices can provide renewable power to remote communities but may also contribute to fragmenting already poorly connected riverine habitats and the impact could be particularly pronounced for migratory diadromous aquatic species such as salmonids by limiting their ability to pass the turbines. Optimising the design of such turbines is therefore essential to mitigate their impact on aquatic fauna. One easily altered property that does not impact turbine performance is blade colour. Here, juvenile rainbow trout (Oncorhynchus mykiss) free swimming within a flume were monitored in the presence of a vertical axis turbine that was either stationary or rotating, and coloured white or orange. The orange colour of the turbine affected behaviour by increasing turbine avoidance and decreasing the number of potentially harmful interactions with the turbine when it was rotating, whilst not affecting passage or mobility of the trout compared to the white turbine. Visibility is therefore a potentially useful tool in mitigating the environmental impact of hydrokinetic turbines.

Abstract Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction of apoptosis. Phosphorylation of ceramide produces ceramide 1-phosphate (C1P), which has opposite effects to ceramide. C1P is mitogenic and has prosurvival properties. In addition, C1P is an important mediator of inflammatory responses, an action that takes place through stimulation of cytosolic phospholipase A2, and the subsequent release of arachidonic acid and prostaglandin formation. All of the former actions are thought to be mediated by intracellularly generated C1P. However, the recent observation that C1P stimulates macrophage chemotaxis implicates specific plasma membrane receptors that are coupled to Gi proteins. Hence, it can be concluded that C1P has dual actions in cells, as it can act as an intracellular second messenger to promote cell survival, or as an extracellular receptor agonist to stimulate cell migration.

Abstract Hydrokinetic turbines such as vertical axis turbines (VATs) may provide decentralised, clean, sustainable energy for remote communities that lack access to the main energy grid or renewable resources. As traditional hydropower adversely alters aquatic ecosystems, it is essential to evaluate the environmental consequences of deploying VATs in riverine ecosystems to meet current and future energy needs. This study explores the implications of VATs on fish movement by observing fish swimming behaviour under two discharges, turbine operation states, and cross-sections confinements using scaled laboratory experiments. Our findings reveal that for cross-sectional confined conditions neither discharge, turbine presence, nor device operation, prevented fish from passing around and through the turbine both in the up- and downstream directions. However, fish spent the least time near the turbine vicinity and within the turbine’s turbulent, low-velocity wake, indicating avoidance behaviour. Swimming in a less confined test section further reduced the time spent within the turbine’s vicinity and wake, increasing the distance fish kept away from the device. Our results contribute to an understanding of VATs as low-risk hazards for fish swimming behaviour, advancing the potential of deploying VATs in rivers, estuaries or sea as a renewable energy solution for remote communities.

Photovoltaic systems are prone to breaking down due to harsh conditions. To improve the reliability of these systems, diagnostic methods using Machine Learning (ML) have been developed. However, many publications only focus on specific AI models without disclosing the type of learning used. In this article, we propose a supervised learning algorithm that can detect and classify PV system defects. We delve into the world of supervised learning-based machine learning and its application in detecting and classifying defects in photovoltaic (PV) systems. We explore the various types of faults that can occur in a PV system and provide a concise overview of the most commonly used machine learning and supervised learning techniques in diagnosing such systems. Additionally, we introduce a novel classifier known as Extra Trees or Extremely Randomized Trees as a speedy diagnostic approach for PV systems. Although this algorithm has not yet been explored in the realm of fault detection and classification for photovoltaic installations, it is highly recommended due to its remarkable precision, minimal variance, and efficient processing. The purpose of this article is to assist technicians, engineers, and researchers in identifying typical faults that are responsible for PV system failures, as well as creating effective control and supervision techniques that can minimize breakdowns and ensure the longevity of installed systems.

A escassez de água potável vem se revelando um problema que afeta inúmeros países no mundo inteiro, sendo, porém, mais acentuada em regiões carentes de infraestrutura. O presente estudo busca discutir o problema do acesso à água na região norte do Brasil, tendo como objetivo geral analisar as causas e as consequências da falta de abastecimento de água potável às populações ribeirinhas do estado do Amazonas, apontando as principais ações que podem ajudar a minimizar tal situação. Para alcançar este objetivo serão desenvolvidos como objetivos específicos: a) Levantamento teórico acerca da escassez de água doce e do seu direito de acesso; b) Verificação acerca da carência de água potável na região norte do Brasil e; c) Análise das dificuldades observadas no âmbito das comunidades ribeirinhas do Estado do Amazonas. Trata-se de uma pesquisa qualitativa, desenvolvida no método dedutivo, baseada em revisão bibliográfica e documental.

Abstract Background Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a key protein serving as the mitochondrial gatekeeper, the voltage-dependent anion channel-1 (VDAC1) that controls metabolism and Ca2+ homeostasis is positioned at a convergence point for various cell survival and death signals. Here, we targeted VDAC1 with VBIT-4, a newly developed inhibitor of VDAC1 that prevents its pro-apoptotic activity, and mitochondria dysfunction. Methods To address the multiple pathways involved in AD, neuronal cultures and a 5 × FAD mouse model of AD were treated with VBIT-4. We addressed multiple topics related to the disease and its molecular mechanisms using immunoblotting, immunofluorescence, q-RT-PCR, 3-D structural analysis and several behavioral tests. Results In neuronal cultures, amyloid-beta (Aβ)-induced VDAC1 and p53 overexpression and apoptotic cell death were prevented by VBIT-4. Using an AD-like 5 × FAD mouse model, we showed that VDAC1 was overexpressed in neurons surrounding Aβ plaques, but not in astrocytes and microglia, and this was associated with neuronal cell death. VBIT-4 prevented the associated pathophysiological changes including neuronal cell death, neuroinflammation, and neuro-metabolic dysfunctions. VBIT-4 also switched astrocytes and microglia from being pro-inflammatory/neurotoxic to neuroprotective phenotype. Moreover, VBIT-4 prevented cognitive decline in the 5 × FAD mice as evaluated using several behavioral assessments of cognitive function. Interestingly, VBIT-4 protected against AD pathology, with no significant change in phosphorylated Tau and only a slight decrease in Aβ-plaque load. Conclusions The study suggests that mitochondrial dysfunction with its gatekeeper VDAC1 is a promising target for AD therapeutic intervention, and VBIT-4 is a promising drug candidate for AD treatment.

This study proposes a framework to facilitate the Circular Economy (CE) implementation cases analysis from the Institutional Theory (IT) perspective. The development of this theoretical framework was based on the levels of operationalisation of the Circular Economy and the types of isomorphic changes. To demonstrate the framework's applicability, we present a matrix classifying 59 case studies into nine quadrants (3 x 3). Subsequently, the papers' contents were discussed, revealing strategies and practices for institutional behavioural change that drive CE implementation at the micro, meso, and macro levels. Therefore, the results of this work contribute not only to academia by introducing a new way of analysing CE case studies but also to managers by discussing implemented or ongoing implementation cases.

IntroductionDynamic susceptibility-weighted contrast-enhanced (DSC) perfusion studies in magnetic resonance imaging (MRI) provide valuable data for studying vascular cerebral pathophysiology in different rodent models of brain diseases (stroke, tumor grading, and neurodegenerative models). The extraction of these hemodynamic parameters via DSC-MRI is based on tracer kinetic modeling, which can be solved using deconvolution-based methods, among others. Most of the post-processing software used in preclinical studies is home-built and custom-designed. Its use being, in most cases, limited to the institution responsible for the development. In this study, we designed a tool that performs the hemodynamic quantification process quickly and in a reliable way for research purposes.MethodsThe DSC-MRI quantification tool, developed as a Python project, performs the basic mathematical steps to generate the parametric maps: cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), signal recovery (SR), and percentage signal recovery (PSR). For the validation process, a data set composed of MRI rat brain scans was evaluated: i) healthy animals, ii) temporal blood–brain barrier (BBB) dysfunction, iii) cerebral chronic hypoperfusion (CCH), iv) ischemic stroke, and v) glioblastoma multiforme (GBM) models. The resulting perfusion parameters were then compared with data retrieved from the literature.ResultsA total of 30 animals were evaluated with our DSC-MRI quantification tool. In all the models, the hemodynamic parameters reported from the literature are reproduced and they are in the same range as our results. The Bland–Altman plot used to describe the agreement between our perfusion quantitative analyses and literature data regarding healthy rats, stroke, and GBM models, determined that the agreement for CBV and MTT is higher than for CBF.ConclusionAn open-source, Python-based DSC post-processing software package that performs key quantitative perfusion parameters has been developed. Regarding the different animal models used, the results obtained are consistent and in good agreement with the physiological patterns and values reported in the literature. Our development has been built in a modular framework to allow code customization or the addition of alternative algorithms not yet implemented.

Background: One of the main biological mechanisms behind the link between periodontitis and atherosclerotic vascular diseases is vascular endothelial dysfunction. Particularly, circulating endothelial progenitor cells (EPCs) have been considered a biomarker of altered vascular endothelial function. Objectives: The aim of this study was to investigate relationship between periodontal inflammation and increased number of circulating EPCs. Design: This is retrospective cohort study. Methods: In this study, 85 elderly patients with a previous history of hypertension were followed up to 12 months. A baseline full-mouth periodontal assessment was carried out, and the amount of periodontal tissue inflamed per subject was calculated as a proxy of periodontal inflammation [periodontal inflamed surface area (PISA)]. The number of circulating EPCs (CD34 + /CD133 + /KDR + ) was determined by flow cytometry from peripheral blood samples collected at baseline and 12 months. Results: Mean concentrations of CD34 + /CD133 + /KDR + progenitor cells were higher in periodontitis patients than in those without periodontitis at baseline [55.4, 95% confidence interval (CI) = 20.8 to 90.0 versus 27.2, 95% CI = 13.6 to 40.8, p = 0.008] and 12 months (114.6, 95% CI = 53.5 to 175.7 versus 19.1, 95% CI = 10.8 to 27.4, p = 0.003). A significant increase over the follow-up was noticed in the group of subjects with periodontitis ( p = 0.049) but not in the nonperiodontitis group ( p = 0.819). PISA was independently associated with CD34 + /CD133 + /KDR + EPCs at baseline ( B coefficient = 0.031, 95% CI = 0.005 to 0.058; p = 0.021). The relationship between PISA and CD34 + /CD133 + /KDR + EPCs at 12 months was confounded by increased baseline body mass index ( B coefficient = 0.064, 95% CI = −0.005 to 0.132; p = 0.066). Conclusion: Periodontal inflammation is associated with high number of CD34 + /CD133 + /KDR + EPCs, thus supporting a potential link between periodontitis and endothelial dysfunction.

The urgency to mitigate the effects of climate change necessitates an unprecedented global deployment of offshore renewable-energy technologies mainly including offshore wind, tidal stream, wave energy, and floating solar photovoltaic. To achieve the global energy demand for terawatt-hours, the infrastructure for such technologies will require a large spatial footprint. Accommodating this footprint will require rapid landscape evolution, ideally within two decades. For instance, the United Kingdom has committed to deploying 50 GW of offshore wind by 2030 with 90–110 GW by 2050, which is equivalent to four times and ten times more than the 2022 capacity, respectively. If all were 15 MW turbines spaced 1.5 km apart, 50 GW would require 7500 km ^2 and 110 GW would require 16 500 km ^2 . This review paper aims to anticipate environmental impacts stemming from the large-scale deployment of offshore renewable energy. These impacts have been categorised into three broad types based on the region (i.e. atmospheric, hydrodynamic, ecological). We synthesise our results into a table classifying whether the impacts are positive, negative, negligible, or unknown; whether the impact is instantaneous or lagged over time; and whether the impacts occur when the offshore infrastructure is being constructed, operating or during decommissioning. Our table benefits those studying the marine ecosystem before any project is installed to help assess the baseline characteristics to be considered in order to identify and then quantify possible future impacts.

Ischemic stroke is an important cause of mortality and disability worldwide. Given that current treatments do not allow a remarkably better outcome in patients after stroke, it is mandatory to seek new approaches to preventing stroke and/or complementing the current treatments or ameliorating the ischemic insult. Multiple preclinical and clinical studies highlighted the potential beneficial roles of exercise and a Mediterranean diet following a stroke. Here, we investigated the effects of a pre-stroke Mediterranean-like diet supplemented with hydroxytyrosol and with/without physical exercise on male rats undergoing transient middle cerebral artery occlusion (tMCAO). We also assessed a potential synergistic effect with physical exercise. Our findings indicated that the diet reduced infarct and edema volumes, modulated acute immune response by altering cytokine and chemokine levels, decreased oxidative stress, and improved acute functional recovery post-ischemic injury. Interestingly, while physical exercise alone improved certain outcomes compared to control animals, it did not enhance, and in some aspects even impaired, the positive effects of the Mediterranean-like diet in the short term. Overall, these data provide the first preclinical evidence that a preemptive enriched Mediterranean diet modulates cytokines/chemokines levels downwards which eventually has an important role during the acute phase following ischemic damage, likely mediating neuroprotection.

In developing effective energy management mechanisms, new concepts have been developed to provide new approaches. Non-intrusive load monitoring (NILM) is an approach that was originally developed to allow the occupants of a room to identify the contribution of each appliance to the total electricity consumption of the room through a single point measurement device. The aim is to provide customers with information that will enable them to act as `` ` consum'actors", i.e., people who undertake to change their electricity consumption habits for an objective cause. The progress of artificial intelligence in its various forms (machine learning, big data, internet of things) have greatly contributed to increase the interest of NILM among researchers in different fields. Indeed, some of them are adapting this concept to research areas such as water, transport, health, the environment and agriculture. In this context, applications in these fields have been developed to show the potential and benefits of using this approach. In addition to presenting non-intrusive load monitoring (NILM) in its general framework, this article presents the interests and applications of this approach in various fields.

Práticas produtivas alinhadas à Economia Circular (EC) tem sido importante para a harmonia entre economia, meio ambiente e sociedade, principalmente quando evoluem para a otimização de recursos e mitigação de impactos ambientais. O objetivo desta pesquisa foi verificar se as práticas que estão sendo adotadas na produção de soja contribuem e estão alinhadas ao que é preconizado pela EC. A pesquisa se classificou como aplicada, qualitativa, exploratória e descritiva, sendo o estudo de caso o procedimento técnico utilizado. Participaram da entrevista 3 produtores de soja. Foram identificadas 18 práticas de EC na produção de soja que estão alinhadas ao que é preconizado pela EC, notadamente as de otimização, regeneração e virtualização, apontando para um caminho mais sustentável de produção e para uma possível transição de uma Economia Linear para uma EC. Production practices aligned with the Circular Economy (CE) have been important for the harmony between economy, environment and society, especially when they evolve towards the optimization of resources and mitigation of environmental impacts. The objective of this research was to verify if the practices that are being adopted in the production of soy contribute and are in line with what is recommended by the CE. The research was classified as applied, qualitative, exploratory and descriptive, with the case study being the technical procedure used. Three soybean producers participated in the interview. 18 CE practices were identified in soybean production that are in line with what is recommended by CE, notably those of optimization, regeneration and virtualization, pointing to a more sustainable path of production and a possible transition from a Linear Economy to an CE.

This study looked at how structural equation modeling using partial least squares of higher order has been used in various fields of science. We used the integrative type of systematic review method for this. We used the Coordination for the Improvement of Higher Education Personnel database. We searched this database for articles with eight different descriptors published between 2010 and 2020. In total, we used 173 articles as the basis for our analysis in our study. We used coding and graph analysis through social network analysis to analyze the data. The main findings show that social science is the most commonly used area for this method, and that most studies do not detail how they conducted the higher-order structural equation through partial least squares modeling. The study also shows which metrics are commonly used and which could be used more effectively for greater reliability.

Abstract Background Ischemic stroke is the most common cerebrovascular disease and is caused by interruption of blood supply to the brain. To date, recombinant tissue plasminogen activator (rtPA) has been the main pharmacological treatment in the acute phase. However, this treatment has some drawbacks, such as a short half-life, low reperfusion rate, risk of hemorrhagic transformations, and neurotoxic effects. To overcome the limitations of rtPA and improve its effectiveness, we recently designed sonosensitive sub-micrometric capsules (SCs) loaded with rtPA with a size of approximately 600 nm, synthesized using the layer-by-layer (LbL) technique, and coated with gelatine for clot targeting. In this study, we evaluated the rtPA release of ultrasound (US)-responsive SCs in healthy mice and the therapeutic effect in a thromboembolic stroke model. Results In healthy mice, SCs loaded with rtPA 1 mg/kg responded properly to external US exposure, extending the half-life of the drug in the blood stream more than the group treated with free rtPA solution. The gelatine coating also contributed to stabilizing the encapsulation and maintaining the response to US. When the same particles were administered in the stroke model, these SCs appeared to aggregate in the ischemic brain region, probably generating secondary embolisms and limiting the thrombolytic effect of rtPA. Despite the promising results of these thrombolytic particles, at least under the dose and size conditions used in this study, the administration of these capsules represents a risk factor for stroke. Conclusions This is the first study to report the aggregation risk of a drug carrier in neurological pathologies such as stroke. Biocompatibility analysis related to the use of nano-and microparticles should be deeply studied to anticipate the limitations and orientate the design of new nanoparticles for translation to humans. Graphical Abstract

Tidal turbines are commonly deployed at sea sites with water depths of up to 50 m to ease their deployment and quick maintenance operations. In these relatively shallow water depth conditions, the vertical expansion of tidal stream turbine wakes is restricted by the proximity of the rotor blades to the bottom bed and free-surface layer. These physical constrains can lead to changes in the flow mechanisms that drive momentum recovery behind the turbines, e.g. limiting the vertical fluxes of velocity. Understanding how the wake recovers depending on the submergence ratio is of utmost importance to designing the future multi-row tidal turbine arrays. Here, we adopt high-fidelity Large-Eddy Simulations (LES) with an Actuator Line Method (ALM) to represent the turbine's rotor to analyse the mean flow and transport equation for mean kinetic energy (MKE) behind a single bottom-fixed tidal turbine for four water depth values. Our results show that the close proximity of the turbine blade tip to the free-surface can notably constrain the wake expansion, with very shallow conditions leading to a limited contribution to the MKE replenishment of the turbulent momentum exchange over the vertical direction. Conversely, under such shallow conditions, the horizontal flux of MKE is enhanced over the lateral boundaries of the downstream wake. Our study evidences that the ratio of water depth to turbine diameter plays a relevant role in future tidal arrays and needs to be correctly accounted for in numerical models to provide reliable results.

A caracterização da modernidade contém uma série de elementos marcantes, que a tornam essencialmente problemática em termos socioambientais. As estruturas sociais e econômicas da modernidade assentam suas bases num modo de produção excessivamente danoso ao equilíbrio dos ecossistemas, graças ao drástico potencial de modificar o meio ambiente adquirido através do desenvolvimento da ciência e da tecnologia. A transição entre o modo de produção manufatureira para a maquinofatureira de produção em massa alterou profundamente as bases de relação entre as sociedades e os elementos naturais, passando-se a consumir com maior voracidade e gerando, por consequência, resíduos que a natureza não consegue absorver segundo sua capacidade de suporte. Portanto, diante das ameaças que passaram a ser observadas, o sistema econômico passou a formular diversas teorias de reestruturação, a exemplo do desenvolvimento sustentável e, mais atualmente, da economia verde, que tem por objetivo a inclusão dos bens comuns nos mercados e a regulação econômica de seu acesso e preservação, tendo-se como principal instrumento deste pensamento os mecanismos de pagamentos por serviços ambientais. No entanto, há vários questionamentos acerca da consistência teórica e prática das ações pautadas nesta racionalidade, sobre os quais se pretende tratar no presente trabalho. Nesse sentido, objetiva-se explicar alguns desses questionamentos e analisar a real efetividade das políticas de mercantilização da natureza pela via dos Pagamentos por Serviços Ambientais para solucionar a crise das sociedades e da natureza no contexto da modernidade.

Résumé : Depuis les années 1990, la diffusion des réseaux sociaux connectés dans les pays du Sud et plus spécifiquement, dans les villes togolaises à l'instar de Sokodé, n'a cessé de transformer les modes de vie des familles et le lien conjugal. C'est pourquoi la présente recherche s'est assigné comme objectif de cerner les usages, les avantages et les inconvénients des usages de réseaux sociaux connectés par les partenaires conjugaux en prenant pour exemple, la ville de Sokodé au Togo. Elle se sert des méthodes d'analyse documentaire, des entretiens individuels approfondis et d’administration d’un questionnaire à 130 conjoints. Il en découle que, les réseaux sociaux connectés tels que Whatsapp, Facebook et Tic Tock, font l’objet de plusieurs usages qui témoignent de leurs multiples avantages informationnels et communicationnels, mais également des inconvénients tels que la désinformation et la déculturation des conjoints, l’affaiblissement des liens conjugaux par déficit de communication en tête à tête entre conjoints, l'addiction aux réseaux sociaux connectés, la crise éducationnelle des enfants, les conflits entre conjoints, conduisant parfois aux divorces et mettant ainsi à rude épreuve les rapports conjugaux.

Ischemic stroke is becoming one of the most common causes of death and disability in developed countries. Since current therapeutic options are quite limited, focused on acute reperfusion therapies that are hampered by a very narrow therapeutic time window, it is essential to discover novel treatments that not only stop the progression of the ischemic cascade during the acute phase, but also improve the recovery of stroke patients during the sub-acute or chronic phase. In this regard, several studies have shown that endothelial progenitor cells (EPCs) can repair damaged vessels as well as generate new ones following cerebrovascular damage. EPCs are circulating cells with characteristics of both endothelial cells and adult stem cells presenting the ability to differentiate into mature endothelial cells and self-renew, respectively. Moreover, EPCs have the advantage of being already present in healthy conditions as circulating cells that participate in the maintenance of the endothelium in a direct and paracrine way. In this scenario, EPCs appear as a promising target to tackle stroke by self-promoting re-endothelization, angiogenesis and vasculogenesis. Based on clinical data showing a better neurological and functional outcome in ischemic stroke patients with higher levels of circulating EPCs, novel and promising therapeutic approaches would be pharmacological treatment promoting EPCs-generation as well as EPCs-based therapies. Here, we will review the latest advances in preclinical as well as clinical research on EPCs application following stroke, not only as a single treatment but also in combination with new therapeutic approaches.

Silicon-based kinetic energy converters employing variable capacitors, also known as electrostatic vibration energy harvesters, hold promise as power sources for Internet of Things devices. However, for most wireless applications, such as wearable technology or environmental and structural monitoring, the ambient vibration is often at relatively low frequencies (1–100 Hz). Since the power output of electrostatic harvesters is positively correlated to the frequency of capacitance oscillation, typical electrostatic energy harvesters, designed to match the natural frequency of ambient vibrations, do not produce sufficient power output. Moreover, energy conversion is limited to a narrow range of input frequencies. To address these shortcomings, an impacted-based electrostatic energy harvester is explored experimentally. The impact refers to electrode collision and it triggers frequency upconversion, namely a secondary high-frequency free oscillation of the electrodes overlapping with primary device oscillation tuned to input vibration frequency. The main purpose of high-frequency oscillation is to enable additional energy conversion cycles since this will increase the energy output. The devices investigated were fabricated using a commercial microfabrication foundry process and were experimentally studied. These devices exhibit non-uniform cross-section electrodes and a springless mass. The non-uniform width electrodes were used to prevent pull-in following electrode collision. Springless masses from different materials and sizes, such as 0.5 mm diameter Tungsten carbide, 0.8 mm diameter Tungsten carbide, zirconium dioxide, and silicon nitride, were added in an attempt to force collisions over a range of applied frequencies that would not otherwise result in collisions. The results show that the system operates over a relatively wide frequency range (up to 700 Hz frequency range), with the lower limit far below the natural frequency of the device. The addition of the springless mass successfully increased the device bandwidth. For example, at a low peak-to-peak vibration acceleration of 0.5 g (peak-to-peak), the addition of a zirconium dioxide ball doubled the device’s bandwidth. Testing with different balls indicates that the different sizes and material properties have different effects on the device’s performance, altering its mechanical and electrical damping.

O principal objetivo deste artigo é analisar e comparar a atual legislação portuguesa sobre o regime de teletrabalho, contida na Lei 83/2021, de 6 de dezembro, que veio alterar o Código do Trabalho, e a atual legislação espanhola, contida na Lei 10/2021, de 9 de julho. Estas legislações foram impulsionadas pela pandemia da COVID-19 e pela subsequente crise económica, bem como pela necessidade de utilizar o teletrabalho para conter a contaminação. Ambos os sistemas jurídicos beneficiam do mesmo enquadramento comunitário e foram influenciados pelo Acordo-Quadro Europeu sobre o Teletrabalho de 2002. No entanto, as leis portuguesas e espanholas escolheram estratégias diferentes na abordagem ao regime do teletrabalho, o que teve repercussões na sua redação legal. Assim, no caso espanhol, foi dada prioridade à negociação coletiva, enquanto no caso português foi o próprio legislador que delimitou os direitos do trabalhador tanto quanto possível. Cada uma dessas abordagens tem aspetos positivos, mas também apresentam pontos que poderão ser melhorados, e que vamos analisar. Quer o regime português, quer o espanhol, podem beneficiar se replicarem algumas das opções normativas do outro regime e, portanto, nas conclusões, deixo algumas propostas nesse sentido.

Abstract The real-time live fluorescent monitoring of surface AMPA receptors (AMPARs) could open new opportunities for drug discovery and phenotypic screening concerning neuropsychiatric disorders. We have developed FORTIS, a tool based on pH sensitivity capable of detecting subtle changes in surface AMPARs at a neuronal population level. The expression of SEP-GluA1 or pHuji-GluA1 recombinant AMPAR subunits in mammalian neurons cultured in 96-well plates enables surface AMPARs to be monitored with a microplate reader. Thus, FORTIS can register rapid changes in surface AMPARs induced by drugs or genetic modifications without having to rely on conventional electrophysiology or imaging. By combining FORTIS with pharmacological manipulations, basal surface AMPARs, and plasticity-like changes can be monitored. We expect that employing FORTIS to screen for changes in surface AMPARs will accelerate both neuroscience research and drug discovery.

Without an appropriate monitoring system, the condition/state of electrical appliances/devices in operation in households cannot be fully assessed, resulting in uncontrolled expenses. The purpose of load monitoring techniques is to save electricity consumption. With proper controls, overconsumption of energy can be reduced and unwanted activity that can lead to unnecessary electricity consumption can be eliminated. To achieve this, two approaches are used. The first approach, which says that each device is monitored by means of individual meters or metering devices, is called intrusive load monitoring (ILM) and requires expensive deployment of metering devices for its use. In contrast to the first one, the second approach is non-intrusive load monitoring (NILM), which monitors electricity consumption without the need for any intrusion. In this configuration, the total energy consumed is disaggregated into the individual consumption of each load. With progress/advances in artificial intelligence, this approach is gaining interest with influences in other areas of research. Knowing that these developed techniques aim to encourage the occupants of dwellings to save energy by optimizing their electricity consumption, the paper presents a comparative study of these approaches, in order to highlight the strengths as well as the weaknesses of each of them. It is therefore a means of offering researchers the opportunity to make choices according to the orientations given to the research work.

Alzheimer’s disease (AD) is the most common degenerative disorder in the elderly in developed countries. Currently, growing evidence is pointing at endothelial dysfunction as a key player in the cognitive decline course of AD. As a main component of the blood–brain barrier (BBB), the dysfunction of endothelial cells driven by vascular risk factors associated with AD allows the passage of toxic substances to the cerebral parenchyma, producing chronic hypoperfusion that eventually causes an inflammatory and neurotoxic response. In this process, the levels of several biomarkers are disrupted, such as an increase in adhesion molecules that allow the passage of leukocytes to the cerebral parenchyma, increasing the permeability of the BBB; moreover, other vascular players, including endothelin-1, also mediate artery inflammation. As a consequence of the disruption of the BBB, a progressive neuroinflammatory response is produced that, added to the astrogliosis, eventually triggers neuronal degeneration (possibly responsible for cognitive deterioration). Recently, new molecules have been proposed as early biomarkers for endothelial dysfunction that can constitute new therapeutic targets as well as early diagnostic and prognostic markers for AD.

Ischemic stroke, caused by the interruption of blood flow to the brain and subsequent neuronal death, represents one of the main causes of disability in worldwide. Although reperfusion therapies have shown efficacy in a limited number of patients with acute ischemic stroke, neuroprotective drugs and recovery strategies have been widely assessed, but none of them have been successful in clinical practice. Therefore, the search for new therapeutic approaches is still necessary. Sphingolipids consist of a family of lipidic molecules with both structural and cell signaling functions. Regulation of sphingolipid metabolism is crucial for cell fate and homeostasis in the body. Different works have emphasized the implication of its metabolism in different pathologies, such as diabetes, cancer, neurodegeneration, or atherosclerosis. Other studies have shown its implication in the risk of suffering a stroke and its progression. This review will highlight the implications of sphingolipid metabolism enzymes in acute ischemic stroke.

Combined hormone drugs are the basis for orally administered contraception. However, they are associated with severe side effects that are even more impactful for women in developing countries, where resources are limited. The risk of side effects may be reduced by non-hormonal small molecules which specifically target proteins involved in fertilization. In this study, we present a virtual docking experiment directed to discover molecules that target the crucial fertilization interactions of JUNO (oocyte) and IZUMO1 (sperm). We docked 913,000 molecules to two crystal structures of JUNO and ranked them on the basis of energy-related criteria. Of the 32 tested candidates, two molecules (i.e., Z786028994 and Z1290281203) demonstrated fertilization inhibitory effect in both an in vitro fertilization (IVF) assay in mice and an in vitro penetration of human sperm into hamster oocytes. Despite this clear effect on fertilization, these two molecules did not show JUNO–IZUMO1 interaction blocking activity as assessed by AVidity-based EXtracellular Interaction Screening (AVEXIS). Therefore, further research is required to determine the mechanism of action of these two fertilization inhibitors.

O presente trabalho tem por objetivo discutir os impactos do desenvolvimentismo na América Latina e as possíveis respostas jurídico-políticas advindas da busca pela efetivação dos direitos socioambientais e da ideia de buen vivir vinda do Constitucionalismo Latino-Americano. Para chegar a esta finalidade, o texto é desenvolvido com base em três objetivos específicos: a) apresentar genericamente os problemas ambientais decorrentes das atividades humanas, em especial, aqueles relacionados à ideia desenvolvimentista; b) destacar os prejuízos desta lógica para a América Latina, e c) trazer reflexões sobre as contribuições possíveis quanto ao reconhecimento e efetivação dos direitos socioambientais e quanto ao buen vivir, enquanto parâmetro para nortear as relações entre natureza e sociedades. O método utilizado é o dialético, buscando tratar o tema pela tríade tese-antítese-síntese, com o fim de trazer uma crítica à situação abordada e lançando luz sobre novas possibilidades de superação. Como conclusão, encontram-se aportes sobre as necessidades de criar novos modelos jurídico-políticos que possam colaborar na construção de alternativas frente aos problemas ambientais observados na sociedade hodierna.

Three guenon species in Taï National Park frequently form and maintain stable polyspecific associations despite significant feeding competition. This dietary overlap provides an opportunity to examine how closely related and anatomically similar taxa process the same foods. Our research examines whether the oral-processing behaviors of these guenons differ when they consume the same foods. Methods: Data on oral-processing behavior were collected on one habituated group each of Cercopithecus campbelli, C. diana, and C. petaurista in Taï National Park, Côte d’Ivoire from January 2016 to December 2018. We recorded the frequency with which foods were introduced to the mouth (ingestive action) and the frequency with which foods were processed using incisors, canines, and postcanine teeth. Oral-processing profiles for species-specific plant foods, fungi, and invertebrates were compared using Monte Carlo resampling. We quantified oral-processing behavior during a total of 2316 five-minute focal periods. Diana monkeys use their incisors significantly more per ingestive action than Campbell’s monkeys or Lesser spot-nosed guenons. Lesser spot-nosed guenons use their incisors more than Campbell’s monkeys. Diana monkeys also use significantly more post-canine chews per ingestive action than Campbell’s monkeys and Lesser spot-nosed guenons. Lesser spot-nosed guenons generally use fewer post-canine chews than Diana monkeys but more than Campbell’s monkeys. Canine use during feeding was rare in all three taxa. The three study species use different oral-processing profiles when consuming the same foods. These results are intriguing given the overall similarity in dental and cranial anatomy in these taxa. The oral-processing profiles we report do not encompass the full dietary breadth of all species; however, the behavioral diversity demonstrated during consumption of the same foods suggests that insight into feeding behavior is more likely obtained by examining oral processing of individual foods rather than broad food categories. Furthermore, these results underscore that important variation in feeding behavior is not necessarily associated with morphological differences in dental or craniofacial anatomy.

The performance of cable flow-altering bed scour countermeasures was experimentally evaluated based on the scour reduction, bed morphology, and the effects on the flow field. An unprotected 40 mm diameter pier was compared to piers protected with spiral cables (2, 4, 6, 8 and 10 mm diameters) wrapped at a 15-degree angle for two-bed sediment sizes with median grain sizes of 0.86 and 1.83 mm, for a cylinder Reynolds number of 7120. The scour depth was reduced by the cables by up to 52 percent compared to the unprotected pier case, a reduction that increased with increasing cable diameter for both sediment beds. Scour depth and sediment deposition varied by sediment size, where the scour hole was up to 45 percent deeper for the finer sediment bed than that of the coarser bed. Velocity and turbulence statistics showed that cables attenuated the flow within the scour hole by diminishing the downflow and horseshoe vortex, whereas in the case of finer sediment, spatially averaged turbulent kinetic energy and Reynolds shear stresses were respectively up to 1.4 and 1.8 times higher for the unprotected pier than the protected pier, resulting in scour depth reduction. The presence of the cable also reduced the vortex shedding frequency in the pier wake as indicated by a Strouhal number of around 0.175. The results demonstrate the potential of cable threading as a flow-altering scour countermeasure to reduce bridge pier scour.

Solar photovoltaic (PV) panels are very slender structures that can be equipped with a tracking system to adjust their orientation and maximise their energy yield. Theses slender structures are exposed to wind loads and their aerodynamic response can vary considerably depending on the wind speed and operating tilt angle (θ) that can be in the range of ±60∘. Large-eddy simulations are performed to unveil the governing mechanisms involved in the vortex shedding and mean flow separation around a solar PV panel. Our results show that three regimes can be distinguished: at θ=±10∘, leading-edge vortices are shed and convected along the panel’s surface without significant flow separation; at θ=±10∘−35∘, a low-frequency large-scale structure governs the vortex shedding with less-energetic tailing- and leading-edge vortices being shed at higher frequencies; and, at θ=±35∘−60∘, the flow on the suction side is fully separated by non-symmetric vortex shedding due to the proximity of the structure to the bottom ground. The highest Strouhal number is observed for θ=±35∘ at which the tilt moment coefficient is also maximum. Decreasing the distance to the ground slightly increased the Strouhal number for negative tilt angles whilst no changes were observed for positive inclinations.

IntroductionArgus is an open source electronic solution to facilitate the reporting and management of public health surveillance data. Its components include an Android-phone application, used by healthcare facilities to report results via SMS; and a central server located at the Ministry of Health, displaying aggregated results on a web platform for intermediate and central levels. This study describes the results of the use of Argus in two regions of Togo.MethodsArgus was used in 148 healthcare facilities from May 2016 to July 2018, expanding to 185 healthcare facilities from July 2018. Data from week 21 of 2016 to week 12 of 2019 was extracted from the Argus database and analysed. An assessment mission took place in August 2016 to collect users' satisfaction, to estimate the concordance of the received data with the collected data, and to estimate the time required to report data with Argus.ResultsOverall completeness of data reporting was 76%, with 80% of reports from a given week being received before Tuesday 9PM. Concordance of data received from Argus and standard paper forms was 99.7%. Median time needed to send a report using Argus was 4 minutes. Overall completeness of data review at district, regional, and central levels were 89%, 68%, and 35% respectively. Implementation cost of Argus was 23 760 USD for 148 facilities.ConclusionsThe use of Argus in Togo enabled healthcare facilities to send weekly reports and alerts through SMS in a user-friendly, reliable and timely manner. Reengagement of surveillance officers at all levels, especially at the central level, enabled a dramatic increase in completeness and timeliness of data report and data review.

Ao final da República de Platão, Sócrates conta o Mito de Er. Trata-se de uma descrição do destino das almas após a morte. Segundo o mito, depois de receberem as recompensas por suas vidas, as almas escolhiam o modelo de sua próxima vida. Somente a alma de um filósofo podia fazer uma boa escolha. Quer dizer, no Mito de Er, a filosofia é o que nos torna capazes de viver de forma boa. Ela é, portanto, essencialmente ética: seu fim é a boa vida, que engloba boas escolhas e ações. Já no Fédon Sócrates afirma que a filosofia é, ao contrário, o exercício para a morte. Diante dessa contradição, nosso texto reflete sobre o sentido de “morte” no último diálogo citado. Para isso, será preciso compreender os sentidos de “alma”, “corpo” e “cuidado”, phrónesis. Dessa forma, será possível descobrir se “boa vida” e “morte” podem significar o mesmo, a filosofia.

As cooperativas são instituições distintas, de fato das transformações que acontecem por meio da globalização e da concorrência. Portanto, essas mudanças estruturais e pressões ambientais levam as cooperativas a uma crise de identidade. Também essas transformações favorecem o surgimento de um novo paradigma cooperativo. Esse novo paradigma baseia-se na capacidade das organizações cooperativas a se tornar competitivas face aos desafios dos concorrentes capitalistas. O objetivo do presente trabalho é mostrar a importância da gestão cooperativa e da prática democrática para evitar um eventual crise de identidade cooperativa. A metodologia empregada é a revisão bibliográfica seletiva a partir dos artigos e revistas cooperativas publicadas no sítio do cooperativismo, e também na base de dados do Google Acadêmico e Scielo entre os anos 2000 e 2017. Como resultado, percebe se que a gestão e a prática democrática são os pilares da cooperativa e sem esses dois elementos a cooperativa não alcança o verdadeiro equilíbrio cooperativo e logo entra em uma crise de identidade.

Os cooperados face ao movimento capitalista precisam se posicionar melhor através de seus valores e finalidades. Assim, para se colocar no debate atual, o movimento cooperativo deve consolidar seus próprios fundamentos na recuperação de sua visão original do ser humano. O movimento cooperativo deve manifestar concretamente seu posicionamento na comunidade. Em um contexto de globalização, os desafios não são mais apenas econômicos, mas sim sociais. A cooperativa não é somente uma organização econômica original, mas uma escola humanista que deve contribuir para posicionar o cooperado como uma pessoa e como cidadão em um mundo dominado pela ignorância humana. O objetivo desta pesquisa é apresentar uma reflexão sobre o paradigma cooperativo através de uma abordagem metodológica e teórica, permitindo assim uma melhor compreensão dos valores, dos fundamentos cooperativos e também das contribuições socioeconômicas do movimento cooperativista no mundo. Essa atividade pode levar à possível modelização do paradigma cooperativo

Blood-brain barrier (BBB) integrity is essential to maintaining brain health. Aging-related alterations could lead to chronic progressive leakiness of the BBB, which is directly correlated with cerebrovascular diseases. Indeed, the BBB breakdown during acute ischemic stroke is critical. It remains unclear, however, whether BBB dysfunction is one of the first events that leads to brain disease or a down-stream consequence. This review will focus on the BBB dysfunction associated with cerebrovascular disease. An added difficulty is its association with the deleterious or reparative effect, which depends on the stroke phase. We will first outline the BBB structure and function. Then, we will focus on the spatiotemporal chronic, slow, and progressive BBB alteration related to ischemic stroke. Finally, we will propose a new perspective on preventive therapeutic strategies associated with brain aging based on targeting specific components of the BBB. Understanding BBB age-evolutions will be beneficial for new drug development and the identification of the best performance window times. This could have a direct impact on clinical translation and personalised medicine.