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Introduction Odontogenic infections are one of the common causes of maxillary sinusitis. With the close proximity of the roots of maxillary posterior teeth to the sinus floor, the infection may spread into the sinus causing sinus mucosal thickening. This study aims to evaluate the association between maxillary posterior teeth periapical pathologies and maxillary sinus mucosal changes using cone-beam computed tomography (CBCT) images.

In the title molecule, C24H29NO4, the central ring of the acridinedione system adopts a flat boat conformation and the four essentially planar atoms of this ring [maximum deviation = 0.001 (2) Å] form a dihedral angle of 85.99 (12)° with the benzene ring. The two outer rings of the acridinedione system adopt sofa conformations. In the crystal, O—H...O and N—H...O hydrogen bonds link the molecules, forming a two-dimensional network parallel to (100).

Introduction: Sports offer numerous health benefits, contributing to growth, development, physical fitness, and mental well-being. However, injuries are an inevitable part of sports, affecting both professional athletes and casual participants. The incidence of sports-related injuries has risen significantly due to increased participation, heightened competitiveness, inadequate injury prevention techniques, improper sporting gear, insufficient training, and overuse. Method: ology: A comprehensive literature search was performed in multiple databases such as PUBMED and SCOPUS. Relevant studies on therapeutic uses of platelet-rich plasma (PRP) in sports injuries were included. The findings provide a comprehensive overview of the topic. Results: Platelet-Rich Plasma (PRP) is a regenerative, minimally invasive, non-surgical procedure that accelerates healing by utilizing concentrated bioactive factors from the body. PRP has shown promising results in treating conditions such as patellar tendonitis, Achilles tendonitis, tennis elbow, partial rotator cuff tears, ligament tears, and mild to moderate arthritis. Following a PRP injection, athletes typically undergo a short period of rest from sports activities while attending rehabilitation therapy. This approach helps optimize healing and ensures an optimal outcome. Conclusion: PRP has shown great promise as a treatment modality for sports injuries. While further research is needed to optimize PRP protocols and understand its mechanisms of action in sports injuries, it holds significant potential for enhancing the recovery and rehabilitation of athletes, ultimately contributing to improved outcomes in the field of sports medicine.

Introduction: The success of implant therapy depends on a number of parameters, including bone volume implant shape, surface topography, the patient’s overall health, and local factors. Despite the fact that polyetheretherketone (PEEK) implants have undergone a lot of alterations, only a small number of studies have examined the bioactivity and osseointegration of PEEK implants with titanium. Aim: To summarise and evaluate protein adsorption and osseointegration capacity of PEEK and titanium dental implants. Materials and Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used and PROSPERO (CRD42023415494) registration was done. Electronic databases were searched for studies assessing the outcome in terms of protein adsorption and osseointegration capacity of PEEK and titanium dental implants. Quality assessment of included studies was evaluated using the Newcastle-Ottawa Scale (NOS). Results: Depending on inclusion and exclusion criteria, seven studies fulfilled the eligibility criteria and were included in qualitative synthesis. Risk of bias assessment revealed that all the included studies were largely comparable in methodological quality. All the included studies had moderate to low-risk of bias with all the respective domains. All the included studies revealed that PEEK with optimal surface roughness might hold great potential for protein adsorption and osseointegration capacity. Conclusion: Within the limitations of the study, it was found that compared to titanium, PEEK is less osseoconductive and bioactive. PEEK is therefore unsuitable for use as a dental implant in its unmodified form. Implantitis and implant failure occurs from improper osseoconductivity and bioactivity of dental implants.

Investigating the effects of periodic magnetic field and triple diffusion on bioconvection flow through a rotating cone populated by oxytactic bacteria and an Eyring-Powell fluid is innovative and significant. The magneto-bioconvection flow of an Eyring-Powell multi-diffusive fluid across a spinning cone is investigated in this paper, considering the effect of oxytactic microorganisms. The non-similar technique is used in the mathematical analysis of the flow over a spinning cone. The flow under consideration contains two diffusive species: liquid hydrogen and liquid oxygen. In light of the periodic magnetic field, the surface gradients, notably skin friction, exhibit wavy effects in the boundary layer domain. The governing equations for the fluid flow in the current flow problem, accompanied by heat diffusion, species diffusion, rotation, bioconvection, and periodic magnetic, are highly coupled nonlinear PDEs dependent on the proper initial and boundary conditions. Mangler's transformations convert them into non-dimensional forms, and numerical non-similar solutions are produced using implicit finite difference approximation and quasi-linearisation. The enriching values of bioconvective Rayleigh number Rb decline the velocity F, as a result, lessen the friction between the surrounding fluid and the cone's surface. The improving Peclet number Pe and microbial density difference σ reduced the microorganism density profile and heightened the microorganism density number Re-1/2Nn.

Objectives: To analyze the clinical and functional outcomes of posterior cruciate ligament avulsion fractures treated by open reduction and internal fixation from tibial attachment. Methods: This observational study was conducted at the orthopedics department of a tertiary care medical college. Forty adult patients with PCL avulsion fractures were included in this study based on predefined inclusion and exclusion criteria. All patients were treated by open reduction and internal fixation. Patients were followed up for one year. The Lysholm scale and knee society score were used to assess functional outcomes. A p-value less than 0.05 was considered to be statistically significant. Results: Overall, 34 (75 %) males and 6 (15%) females participated in this study with an M: F ratio of 1:0.17. The mean age of affected patients was 37.3 +/- 7.34 years. Out of 40 patients, 29 (72.50%) patients sustained fractures secondary to road traffic accidents, while 7 (17.50%) had sports-related injuries. There was a highly significant improvement in the Lysholm and Knee Society scores from the time of presentation to the final follow-up (P

The world is moving towards ubiquitous connectivity, with many devices interconnected and transferring information across the Internet. However, providing Internet connectivity to every device remains challenging, especially in remote geographical areas. It is also difficult for humans to reach remote locations to collect data, hence edge devices need a source to transfer their data across the Internet. Unmanned Aerial Vehicles (UAVs) offer the perfect solution as they can reach remote locations while using lower resources to provide connectivity and collect data from remote devices. Following data collection, the next challenge is data processing. Most of the pre-existing networks process data on the edge device itself, which induces extra load and may lead to data loss from skipping of the data reading cycle. In this paper, various issues related to data logging and analysis in a UAV-assisted Internet of Things (IoT) network are discussed. Issues such as placement of sensor nodes, connectivity to the nodes, UAV platform and tools for the design and development of a UAV-assisted IoT network are presented.

Machining of hard materials has been difficult and expensive because of poor surface smoothness, early tool failures, etc. When used in machining hard materials, such as medium and high carbon, cast steels, Inconel, and other alloys, nanomaterials combined with base fluids, such as water and oils, provide superior results in terms of surface finish and low cutting temperatures. To enhance our understanding of the field of machining and its applications, a comprehensive literature assessment on machining steels using nanofluids with/without the minimum quantity lubrication (MQL) approach was conducted. This research aims to investigate the performance of nanofluids (n-Al2O3, n-MoS2, and n-graphene) mixed with coconut oil in various proportions and injected into the tool–work interface using the MQL mist system. Output responses, such as surface roughness values, and cutting temperatures, were measured. The cutting temperatures were determined using an infrared camera and a k-type thermocouple, and the surface roughness was determined using a Talysurf surface meter. Cutting parameters, such as cutting speed, feed rate, and depth of cut, were maintained constant throughout the experiments. The experiments comprised a single factor (MQL fluid) with eight levels. Multiresponse optimization using grey relational coefficients showed that n-Al2O3 and n-MoS2 hybrid combinations with coconut oil yielded better results, i.e., higher ranks, compared with n-graphene mixtures in coconut oils. The experimental findings demonstrated that nanofluids outperformed pure coconut oil. Nano-Al2O3 combined with coconut oil produced a superior surface finish, lowered the cutting temperatures, and ensured minimum chip thickness.

Cutting fluid is a major concern in conventional cooling methods because of its high cost, effects on operator health, and environmental consequences. Microlubrication (MQL) is a better cooling method than traditional cooling. MQL can be used for machines with a high metal removal rate, such as those used in metal turning, milling, drilling, and boring. MQL has a lower lubrication consumption, a higher cooling rate, and a cleaner production than do conventional flooded lubrication. This study performed a cost-benefit analysis to compare MQL with conventional flood cooling methods. For both traditional flood cooling at 35 L/min and MQL cooling at 50 mL/h, face and slot milling techniques with constant machining settings were used. The quantity of components that must be produced to recoup the fixed and variable costs of MQL and conventional cooling were calculated by performing a breakeven point (BEP) analysis. The MQL methodology used 20% fewer components to recoup all expenses compared with conventional cooling. The findings indicated that MQL is more economical than traditional cooling. Moreover, the BEP for both cooling systems exhibited variances, and the BEP can be reached sooner for MQL than flood cooling lubricant.

AbstractTularemia caused by Gram-negative, coccobacillus bacterium, Francisella tularensis, is a highly infectious zoonotic disease. Human cases have been reported mainly from the United States, Nordic countries like Sweden and Finland, and some European and Asian countries. Naturally, the disease occurs in several vertebrates, particularly lagomorphs. Type A (subspecies tularensis) is more virulent and causes disease mainly in North America; type B (subspecies holarctica) is widespread, while subspecies mediasiatica is present in central Asia. F. tularensis is a possible bioweapon due to its lethality, low infectious dosage, and aerosol transmission. Small mammals like rabbits, hares, and muskrats are primary sources of human infections, but true reservoir of F. tularensis is unknown. Vector-borne tularemia primarily involves ticks and mosquitoes. The bacterial subspecies involved and mode of transmission determine the clinical picture. Early signs are flu-like illnesses that may evolve into different clinical forms of tularemia that may or may not include lymphadenopathy. Ulcero-glandular and glandular forms are acquired by arthropod bite or handling of infected animals, oculo-glandular form as a result of conjunctival infection, and oro-pharyngeal form by intake of contaminated food or water. Pulmonary form appears after inhalation of bacteria. Typhoidal form may occur after infection via different routes. Human-to-human transmission has not been known. Diagnosis can be achieved by serology, bacterial culture, and molecular methods. Treatment for tularemia typically entails use of quinolones, tetracyclines, or aminoglycosides. Preventive measures are necessary to avoid infection although difficult to implement. Research is underway for the development of effective live attenuated and subunit vaccines.

الملخص: أهداف البحث: باليبيريدون هو عقار نظام تصنيف الصيدلة الحيوية الدرجة الثانية ذو قابلية منخفضة للذوبان ونفاذية عالية. يحتوي على 28 ٪ من التوافر الحيوي عن طريق الفم المطلق ونصف عمر التخلص منه 23 ساعة. من أجل تحقيق إطلاق متحكم به على مدى فترة طويلة من الوقت بجرعة منخفضة وتجنب الحاجة إلى جرعة تحميل، يباع الجهاز اللوحي ثلاثي الطبقات التناضحي الدفع والسحب حاليا في السوق. ومع ذلك، فإن الأجهزة اللوحية ثلاثية الطبقات لها عيوب عديدة مثل العملية المعقدة وتكلفة الإنتاج العالية وصعوبة تحقيق توحيد المحتوى. وبالتالي كان الهدف من هذه الدراسة هو التغلب على الصعوبات المذكورة أعلاه المرتبطة بالريسبيريدون وصياغة قرص ثنائي الطبقة له خصائص دوائية مماثلة لتلك الخاصة بالعقار المرجعي إنفيجا. طريقة البحث: تم تحضير الأقراص ثنائية الطبقة عن طريق تحسين اللب والغشاء شبه المنفذ. تم تحليل التأثير الإضافي لوقت المعالجة مع حجم وعدد الفتحة على ملف الذوبان للأقراص المعدة. تم استخدام درجتين مختلفتين من أكسيد البولي إيثلين في الطبقة الأساسية وطبقة الدفع كمشكلين للمسام. النتائج: كانت قيم اختلاف الوزن والقابلية للتلف والصلابة للأقراص المحضرة ضمن حدود الخلاصة. كانت المعلمات المحسنة ثنائية الطبقة للقرص المحضر هي وقت المعالجة 5 ساعات، وطبقة الختم 7٪ وزن/وزن، وغطاء ''إي آر'' 13% وزن/وزن، وحجم الفوهة 0.6 مم، وعدد الفوهة -02. أظهرت صياغة أخرى للأقراص قيمة ''إف 2'' تبلغ 75.67 مما يشير إلى أن ملف تعريف الذوبان الخاص بها مشابه للدواء المرجعي إنفيجا. الاستنتاجات: وهكذا في العمل الحالي، تم إعداد قرص ثنائي الطبقة من الباليبيريدون للتغلب على العيوب المرتبطة بالتركيبة المسوقة بنجاح، مما يوفر مزايا مثل عملية تحضير أبسط، وفعالية من حيث التكلفة، وإعداد أقل استهلاكا للوقت للب القرص. Abstract: Objectives: Paliperidone is a BCS class II drug with low solubility and high permeability. It has 28% absolute oral bioavailability and an elimination half-life of 23 h. An osmotic push–pull trilayer tablet currently available on the market has achieved controlled release of a low dose over an extended time period, while avoiding the need for a loading dose. However, this trilayer tablet has several disadvantages, such as complicated processing, high production costs and difficulty in achieving uniformity of the contents. Thus, the objective of this study was to overcome the above difficulties associated with paliperidone and to formulate a bilayer tablet with a similar drug profile to that of the reference listed drug Invega®. Methods: The bilayer tablets were prepared by optimization of the core and semi-permeable membrane. Effects of the curing time, and the size and number of orifices on the prepared tablets’ dissolution profile were analyzed. Two different grades of polyethylene oxide were used in the core and push layer as pore formers. Results: The weight variation, friability and hardness values of the prepared tablets were well within compendium limits. The optimized bilayer parameters for the prepared tablets were curing time, 5 h; seal coat, 7% w/w; ER coat, 13% w/w; orifice size, 0.6 mm; and orifice number, 2. Further tablet formulation resulted in an F2 value of 75.67, indicating a dissolution profile similar to that of Invega®. Conclusion: Bi-layer tablets of paliperidone overcoming the drawbacks of the marketed formulation were successfully prepared, and offer advantages such as a simpler preparation process, cost effectiveness and faster preparation of the tablet core.

Purpose To evaluate the safety and efficacy of vacuum-assisted breast biopsy (VABB) under ultrasound and stereotactic guidance.

Background: A variety of neoplastic and non-neoplastic conditions involve the nasal cavity and paranasal sinuses, amongst which the prevalence of non-neoplastic sinonasal lesions in the general population is 1-4%. It can give rise to a very diverse assay of neoplasms i.e., about 1% of all malignancies. Methods: The study was conducted in the Department of Pathology Mahadevappa Rampure Medical College over a period of two years (2019-2021). A total of 30 cases of sinonasal tract lesions were identified and their histopathological examination was carried out and special staining was done wherever necessary. Results: Out of 30 sinonasal cases, 16 lesions were inflammatory, seven lesions were benign neoplastic lesions and the other seven were malignant. Nasal polyps were the most common inflammatory lesions, mostly in females. Out of seven malignant lesions, squamous cell carcinoma was found in three lesions, and in benign lesions, sinonasal papillomas were found in five lesions. Conclusion: Various lesions of the sinonasal tract including non-neoplastic, benign, and malignant can occur in any age group and both sexes.

Abstract Background The era of nanotechnology become widespread for research and human resource development due to its functionalized tuning with economical, eco-friendly, effective and sustainable end-products. Hence, the present review illustrates the biogenic fabrication of platinum nanoparticles (PtNPs) through the different sustainable and cheaper approaches. Main body of the abstract Over the physicochemical-based nanotechnology, the biogenic active substances-based synthesis displayed the more promising candidature due to its non-toxic, Broad-spectrum applicability and defendable type character. The biogenic synthesis method is capable with and without capping and highly motif of reducing agents. The morphology and stability of synthesized PtNPs are mostly mediated by various experimental conditions such as pH, temperature, incubation time, concentrations of biomaterials and salts or enzymes used. Hence, the review is aiming to discuss the methodology of biogenic synthesis of PtNPs by plant stem, root, leaf, flower, fruit, extracts, algae, fungi and egg yolk. Also, we have illustrated the pharmaceutical drug model application and its adverse effect. Short conclusion Synthesized PtNPs are open a new trend in catalyst, drug and its carrier and in cancer treatment. PtNPs are utilized as a new therapeutic agent for inhibiting the microbial pathogens with non-toxic behavior. The characterization of PtNPs could estimate the bio-sensitized properties which leads the commercial applications.

Plants being sessile organisms, face environmental challenges and climate change scenarios, that often occur simultaneously (as dual or multifactorial) rather than as a single stress factor. Combined stresses may exert additive impacts on plant growth and yields. The prime challenge to safely feed the burgeoning population, in light of climate change issues, demands precise agriculture systems. Though traditional breeding methods have been utilised but with limited success owing to time, cost, and infrastructure constraints. Modern biotechnological tools, especially the high-throughput omics including genomics, transcriptomics, miRNAomics, metabolomics, lipidomics beside others are being advocated to revolutionize the science of stress biology and to develop stress-smart crops. Omics tools, databases, and pipelines coupled with machine learning, artificial intelligence, and mathematical modeling are proving highly effective not only in deciphering the mechanistic insights of plant stress responses but also in enhancing the stress-tolerance. This review presents current knowledge and updates on recent developments on plant abiotic stress responses and adaptive strategies especially against combined and sequential stresses. Latest developments in omics toolbox and how they are being explored via genetic and genomic engineering, RNA-interference, microRNAs and target mimicry are discussed in detail. Recent success in deployment of biotechnological/omics technologies in modern breeding practices for producing multi-abiotic stress tolerant crops, current challenges and key questions and futuristic trends have also been discussed.

AbstractBackground The multi-country mpox outbreak across the globe has led to the systematic surveillance of mpox cases in India. During the surveillance of mpox, we encountered cases of Varicella Zoster Virus (VZV) in suspected mpox cases amongst children & adults. This study focused on the genomic characterization of VZV in India.Methods A total of 331 mpox suspected cases were tested for VZV through real-time PCR, and the positive samples were subjected to next-generation sequencing to retrieve the whole genome of VZV using CLC genomics software. Phylogenetic analysis has been done in MEGA 11.0 software to identify circulating clades.Result Of the 331 suspected cases, 28 cases with vesicular rashes were found to be positive for VZV. The maximum genome could be retrieved from the clinical specimens of 16 cases with coverage greater than 98% when mapped with reference strain Dumas (NC 001348). The phylogenetic analyses of these sequences determined the circulation of clades 1, 5, and 9 in India. Further, the sequence analysis demonstrated non-synonymous single nucleotide polymorphism (SNPs) among specific ORF of VZV including ORF 14, ORF 22, ORF 36, ORF 37 and ORF 51. Although clade 1 and 5 has been reported earlier, the circulation of clade 9 of VZV has been determined for the first time in India.Conclusion Although the circulation of different clades of VZV was reported from India, the presence of clade 9 was detected for the first time during the mpox surveillance.

Background: Distal radius fractures are among the most common upper extremity fractures and the second most common overall fracture in Orthopedics and trauma. Deciding between non-operative or operative management depends on the patient factors, fracture pattern, displacement and the treating orthopedic surgeon. The objective of our study was to assess the functional and radiological outcome in lower end radius fractures, treated or untreated at the end of 1 year follow up. Material and methods: Our study was a prospective hospital-based study during the period January 2021 and December 2022. All closed lower end radius fractures meeting the inclusion/exclusion criteria and willing for follow-up assessments were included in the study. Study subjects were divided into 2 groups-Treated/Operated group & Untreated/Non-operated group of patients. All patients were followed up at 6 weeks, 3 months and 1 year post injury and their functional and radiological outcomes were assessed and compared between the 2 groups. Results: A total of 100 patients were included in the study who met the required inclusion/exclusion criteria. There was 3 times more incidence among males as compared to females. Mean age was 45.1 yrs. High energy injuries were more frequent in younger patients. Frykman type I>II>VIII were the common type of fracture pattern noted in our study. In our study of 100 patients, 41 patients did not undergo operative intervention and 59 patients underwent some form of operative procedure. We observed that the acceptance of operative intervention was more in younger patients. Based on radiological criteria, 72 patients had excellent radiological outcome overall, out of which 49 patients belonged to operative group and only 23 patients belonged to non-operative group. There was only marginally better PRWE –Patient Rated Wrist Evaluation scores in operated group of patients as compared to non-operated group. Conclusions: Lower end radius fractures have a bimodal age of incidence with a peak in younger patients usually associated with high velocity injuries, and in elderly patients usually secondary to low velocity injuries mostly due to falls. Based on Frykman classification, the more severe the injury there is more acceptance of operative intervention. Operative intervention results in better radiological outcome at 1 year.

Abstract Background Osteoporosis, among other bone diseases, has become a prevalent cause of decreased quality of life in older and postmenopausal women. Traditional anti-osteoporotic therapies, though widely prescribed, are limited by a lack of cell- or tissue-specific targeting ability and effectiveness without side effects. Gene therapy is rapidly replacing traditional therapeutics, primarily because of its specific targeting ability and efficiency. Among viral- and non-viral-based gene therapies, the latter is often preferred over the former due to lower cytotoxicity, immunogenicity, and ease of modification with different molecules to improve efficiency and extend gene expression. We designed and synthesized a multifunctional bone-targeting ribonucleic acid (RNA) delivery system based on polyamidoamine (PAMAM). PAMAM was modified with the serine-aspartate-serine-serine-aspartate (SDSSD) peptide to deliver antagomir 138-5p to osteoblasts (MC3T3-E1 cell line) in vitro and in vivo using the ovariectomized (OVX) mouse model. Results The results showed that this system was less cytotoxic than polyethylenimine (PEI) and could bind to RNA favorably while maintaining gene delivery ability in vitro. In vivo data showed that the distal tibia and femur of the mice in the PAMAM-SDSSD (PS) + RNA group had improved bone mineral density (BMD), bone mineral content (BMC), and bone volume compared to those in the PS + Negative Control (NC) or OVX groups. Moreover, the femurs of the PS + RNA group mice demonstrated a higher breaking point, stress, stiffness, and elasticity than those of the PS + NC or OVX mice, suggesting improved femur strength in the OVX mice treated with RNA delivered through SDSSD-modified PAMAM. Conclusion This study shows that SDSSD modification of PAMAM not only improves gene delivery capacity but also enhances the cell targeting efficiency of nanoparticles towards osteoblasts. The successful delivery of antagomir 138-5p to osteoblasts demonstrates cell-specificity and gene delivery to alleviate osteoporotic symptoms.

Abstract Background In dentistry, nosocomial infection poses a great challenge to clinicians. The microbial contamination of water in dental unit waterlines (DUWLs) is ubiquitous. Such infected DUWLs can transmit oral microbes in the form of aerosols. Previous studies have suggested treating DUWLs with various disinfectants to reduce cross-contamination. The literature lacks a comparative evaluation of the effect of the use of 0.2% chlorhexidine (CHX) and 0.1% sodium hypochlorite (NaOCl) in DUWLs on aerosolized bacteria generated during dental procedures. Objective To compare the effect of NaOCl and CHX in DUWLs on aerosolized bacteria generated during restorative and endodontic procedures. Materials and methods A total of 132 patients were equally divided into three groups (n = 44 in each group) according to the content of DUWL as follows. Group I—0.1% NaOCl Group II—0.2% CHX Group III—distilled water (Positive control) One-way ANOVA was performed and the Kruskal–Wallis test was used for intergroup comparison. Results For the restorative procedure, inter-group comparison of mean colony-forming units (CFU) scores showed a statistically significant difference between the groups (p - .001) with the score of group 3 higher than group 2 followed by group 1. For the endodontics, an inter-group comparison of CFU scores showed a statistically significant difference between the groups (p - .003) with the mean score in group 1 being the lowest and group 3 being the highest. Conclusion The addition of NaOCl or CHX in DUWLs shows an effective reduction in aerosolized bacteria compared to distilled water.

Abstract We present a gravitoelectric quadrupolar dynamical tidal-interaction Hamiltonian for a compact binary system, that is valid to second order in the post-Newtonian expansion. Our derivation uses the diagrammatic effective field theory approach, and involves Feynman integrals up to two loops, evaluated with the dimensional regularization scheme. We also derive the effective Hamiltonian for adiabatic tides, obtained by taking the appropriate limit of the dynamical effective Hamiltonian, and we check its validity by verifying the complete Poincaré algebra. In the adiabatic limit, we also calculate two gauge-invariant observables, namely, the binding energy for a circular orbit and the scattering angle in a hyperbolic scattering. Our results are important for developing accurate gravitational waveform models for neutron-star binaries for present and future gravitational-wave observatories.

Abstract Background Training law enforcement officers (LEOs) to administer naloxone is a recommended strategy to reduce overdose deaths in the United States. To achieve this, an evidence-based and scalable naloxone training curriculum that is easy to use and readily scalable is needed. Convenient web-based training is a flexible method for delivering educational interventions particularly for LEOs who have irregular or shifting schedules. This study examined the effectiveness of a comprehensive web-based naloxone training that was created in partnership with LEOs on their knowledge, confidence, and attitudes regarding naloxone. Methods From May 2019 to September 2020, five law enforcement departments from Michigan participated in web-based naloxone training. A total of 182 LEOs (77% male) were in the final sample based on matching pre-and post-test surveys. LEOs were assessed on knowledge, confidence, and attitudes towards naloxone. Negative binomial and Poisson regression was conducted to assess associations between knowledge, confidence, and attitudes towards naloxone before and after training. Results Significant improvements in overdose knowledge and confidence were revealed across all departments with median (IQR) total composite scores for knowledge increasing from 35 (32, 37) to 40 (39, 42) (p

Background: Sleep problems have been considered as an unmet public health problem. Sleep problems are mostly under reported and neglected by the Indian population. Very limited studies have been conducted in India on this aspect. Aims and Objectives: The aim of the study was to estimate the prevalence of excessive day time sleepiness (EDS) and its associated factors among urban adult population. Materials and Methods: A community based cross-sectional study was conducted among 409 adults of 20–60 years age group in urban Udaipur. Socio-demographic and other details were obtained using a semi structured questionnaire. Using Epworth Sleepiness Scale, assessment of EDS was assessed. Results: In the present study, mean age of the participants was 40.8 ± 11.3 years. Considering the ESS score of 10 or more, EDS was observed in 60.2% subjects. EDS was associated with age, gender, milk consumption, and mobile use. No significant association was found between EDS with central obesity, body mass index, marital status, literacy, occupation, exercise, smoking, and consumption of alcohol. Conclusion: In the present study, the prevalence of EDS was high. Therefore, early identification of excessive sleep problems and appropriate intervention that address the various determinants of the sleep problems is of prime importance.

This Systematic Review (SR) was to report on the prevalence of pulp stones in the Saudi Arabian (KSA) population. The electronic databases were searched for scientific research articles during May 2021. The data search was performed in electronic search engines like PubMed, Scopus, Web of science, and Saudi Digital Library, and 6 original research articles which fulfilled the eligibility criteria were assessed for qualitative data. The prevalence of pulp stones among the KSA population ranged from 4.6% to 50.93% among the study participants and it ranged between 10.2%−13.34% in the teeth assessed. The pulp stones were more frequently reported in decayed teeth, periodontal diseases, attrition, teeth with dental restorations, and higher in the molar teeth in comparison with the premolar teeth. The data on the prevalence of pulp stones among the Saudi population will be helpful for clinicians in planning endodontic procedures.

AIM: To ascertain the pattern of investigations at first contact in uveitic patients and evaluate compliance to treatment. METHODS: An observational study comprised of 201 uveitic patients presenting for the first time to our centre from January 2019 to June 2020. Detailed information regarding systemic investigations undertaken by specialists at the time of first contact and the cost of these investigations were reviewed on the first visit to our centre. Compliance with the treatment was determined and reasons behind non-compliance were evaluated on the first follow-up in patients who had no improvement in clinical signs and symptoms. RESULTS: The mean age of the study group was 35.35±14.1y and gender composition was 59.7% males and 40.3% females. Anterior uveitis was observed in 45.3% of patients, intermediate uveitis in 31.8% of patients, posterior uveitis in 14.9% of patients and panuveitis in 8.0% of patients. Association with a systemic disease was evident in 17.9% of patients. When compared with standard guidelines and uveitis patterns, systemic investigations were identified to be relevant only in 38.3% of patients. Non-compliance to treatment was documented in 22.4% of patients. Common reasons for non-compliance were inadequate counselling by the treating physician about treatment in 26.7% of patients and a busy schedule at work/school in 22.2% of patients. CONCLUSION: Significant number of investigations performed at first contact is found to be contrary to standard guidelines and are not contributory to the care. About a quarter of patients in this study are found to be non-compliant with the treatment. Compliance is more challenging to achieve in school-going children and working adults. The availability of comprehensive, periodically updated, evidence-based guidelines on the role of investigations and the use of trained counsellors may help to channelize proper evaluation and improve compliance to treatment, respectively, in patients with uveitis.

Abstract Wakes and wake interactions in wind turbine arrays diminish energy output and raise the risk of structural fatigue; hence, comprehending the features of rotor–wake interactions is of practical relevance. Previous studies suggest that vertical axis wind turbines (VAWTs) can facilitate a quicker wake recovery. This study experimentally investigates the rotor–wake and wake–wake interaction of VAWTs; different pitch angles of the blades of the upwind VAWT are considered to assess the interactions for different wake deflections. With stereoscopic particle image velocimetry, the wake interactions of two VAWTs are analysed in nine distinct wake deflection and rotor location configurations. The time‐average velocity fields at several planes upwind and downwind from the rotors are measured. Additionally, time‐average loads on the VAWTs are measured via force balances. The results validate the rapid wake recovery and the efficacy of wake deflection, which increases the available power in the second rotor.

Background: The burden of dengue infection needs to be monitored along with tracking of the changes in dengue virus (DENV) transmission intensity for vaccine introduction decisions. Methods: The seroprevalence of dengue was investigated in Pune City in India, in early 2019 using 1654 sera from apparently healthy human participants enrolled randomly through multistage cluster sampling. We used 797 retrospective human sera from late 2009 for comparison. All sera were assessed for the presence of dengue-specific IgG antibodies. A subset (n = 230) was tested for serotype-specific plaque reduction-neutralizing antibodies against all four serotypes. Results: The dengue IgG seroprevalence of 62.9% (95% CI 59.4–66.1) in 2009 increased to 88.4% (95% CI 86.8–89.8) in 2019. Age-stratified dengue seroprevalence revealed a gradual increase in IgG seropositivity from 70.1% in 0–9 years to 85.0% in 10–19 years. The annual probability of dengue infection estimated as a force of infection was 4.1 (95% CI 3.8–4.5) in 2009, which increased to 10.9 (95% CI 10.2–11.6) in 2019. Analysis of dengue serotype-specific neutralizing antibodies revealed DENV-3 as the dominant serotype. The age of exposure to at least one dengue serotype was reduced in 2019 over 2009. Conclusions: There was a significant increase in the intensity of dengue virus transmission in Pune City over the decade. Since over 85% of the participants above nine years of age had exposure to DENV by 2019, dengue vaccine introduction can be considered. Moreover, such repeated serosurveys in different regions might inform about the readiness of the population for dengue vaccination.

Composite deck slab flooring system is gaining popularity since they allow for simpler, lightweight, and more cost-effective building construction technique. The main constituent materials of a composite slab are profiled deck steel sheet and concrete. Profiled steel sheet serves two purposes: it acts as a main reinforcing structural element as well as a permanent formwork during the construction phase. The efficiency of the composite slab mainly depends upon the shear interaction between concrete and steel decking sheet. This paper contributes to improving the horizontal shear strength of composite slab by utilizing basalt textile reinforced concrete (BTRC) topping. The current research is focused on examining the behavior of this shear bond action and improving its performance even without the shear connectors. Three types of concrete topping and four different shear spans (250 mm, 325 mm, 550 mm, and 625 mm) are the variables of the testing. Based on the load-displacement response, failure mechanisms, maximum strain recorded in concrete/steel, load-slip characteristics, steel-concrete shear bond resistance, and the structural performances of basalt textile-reinforced concrete (BTRC) composite slabs were compared with the conventional concrete (CC) composite slabs. BTRC composite slabs are found to be more ductile than the conventional concrete composite slab, with increased load-bearing and slip resisting capacity. Both the m–k and partial shear connection (PSC) approaches were used to calculate the horizontal shear strength of the composite floor. The m-k technique has proven to be more meticulous than the PSC method.

Sensescape, predominantly explored from the viewpoint of viewscape and soundscape, needs investigation from other senses such as smell, a vital part of place experience. The place experience not only depends on senses but also on how senses act within the context. Cities across developing countries, with dynamic tension of coexistence between traditional and modern, are experiencing transformations, inducing major alterations in urban land-use systems and have started to impact upon urban place experience and urban smellscapes diversities. Smellscape is a complex phenomenon posing challenges to the reductionist approach for better insight, hence requiring an effective conceptual framework for analyzing the smellscape with reference to the transformations in cities. Four urban node precinct typologies, as representative cases from developing countries, namely, traditional, partially transformed, transformed and majorly transformed urban nodes, are assessed and presented in this paper. The smellscape and urban place experience, their interconnectedness, and interdependency are investigated in this paper. Based on interpretive epistemology from the cognition framework, the paper posits that the smellscape has a vital role in urban place experience, it correlates and influences urban place liking, and provides clues for theory building for the assessment of smellscape, an underexplored intangible aspect of sensory place experience.

Laser technology has significantly improved giving better results, which in turn has led to an increase in the indications for laser therapy. Vascular anomalies comprise vascular tumors and malformations. They are classified according to the type of vessels involved including arteries, capillaries, postcapillary venules, veins, lymphatic vessels, and a combination of two or more of these. Laser needs a chromophore to get absorbed and act. Hemoglobin, both oxy and deoxy, is one of the naturally occurring chromophore that is abundant in vascular lesions. Therefore, in most of the vascular lesions, lasers can bring improvement of a varying degree, while for superficial hemangiomas and port wine stain (PWS) laser treatment is now the standard of care. However, even though there is increase in the use of lasers in clinical practice, many surgeons are still unaware of its versatility and they are unsure about its safety. This article provides a brief overview of laser and intense pulsed light (IPL) technology, and describes the key principles in using these energy sources in vascular malformations. Readers are also familiarized with possible adverse effects and measures to prevent and treat them.

Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has subjected us all to difficult times in managing patients, particularly pregnant women. Numerous studies have been conducted during each wave, but limited data is available on maternal and neonatal outcomes. Given that people must coexist with COVID-19, it is crucial to enhance the understanding of antenatal patient management. Aim: To compare the clinical presentation, co-morbidities, and maternal and neonatal outcomes among pregnant women with COVID-19 during the first, second, and third waves of the pandemic. Materials and Methods: This prospective cohort study was conducted in the Department of Obstetrics and Gynaecology (OBG) at JSS Hospital, Mysore, Karnataka, India, from January 2020 to February 2022. A total of 33 expectant mothers with COVID-19 presented during the first wave (from January 30, 2020, to the end of February 2021), 50 expectant mothers with COVID-19 during the second wave (from March 2021 to the end of September 2021), and 19 expectant women with COVID-19 during the third wave (from January 2022 to the end of February 2022). Data were collected for each wave, and a comparison of different variables in all three waves was performed. Microsoft Excel was used for data entry, and analysis was conducted using Statistical Package for Social Sciences (SPSS) version 22.0. Chi-square test was employed to compare the different variables as a test of significance. Results: The mean age of the expecting mothers in the first wave was 27.12±4.35 years, in the second wave was 25.86±3.98 years, and in the third wave it was 24.61±3.98 years, with a p-value=0.103. Symptoms like cough, cold, running nose were highest in the second wave (22 cases, 44.0%), followed by breathlessness in 6 (12.0%) cases, and fever, chills, myalgia, generalised weakness, vomiting in 45 (90.0%) cases. Hypertensive disease of pregnancy was highest in the first wave (8 cases, 24.2%). In the first, second, and third waves, a total of 23 (69.7%), 30 (60.0%), and 12 (63.1%) individuals, respectively, did not have any co-morbidities. The majority of women in the first wave 18 (54.6%) cases and second wave 27 (54.0%) cases were multigravida, while in the third wave, they were primigravida 14 (73.7%) cases. Pre-term deliveries 22 (44.0%) cases and intrauterine deaths 8 (16.0%) cases were highest in the second wave. There was a higher frequency of Preterm Premature Rupture of Membranes (PPROM) and Premature Rupture of Membranes (PROM) in the first wave 6 (18.2%) cases. Neonatal Intensive Care Unit ( NICU) admission of babies was found to be highest in the third wave 8 (42.1%) cases, compared to the first two waves. There was no statistically significant association between these parameters and the waves of the pandemic. The mean Haemoglobin (Hb) levels of the study subjects were least in the first wave, compared to those in the rest of the waves (p-value=0.499). Mean Erythrocyte Sedimentation Rate (ESR) levels were significantly lower in the first wave (p-value=0.041), and C-reactive Protein (CRP) was highest in women in the second wave (p-value=0.036). Conclusion: It is important that always study the features of the disease over a period of time so that the management protocols can be modified.

Mehuli Halder,1 Yogesh Chhaparwal,1 Vathsala Patil,1 Komal Smriti,1 Shubha Chhaparwal,2 Kalyana C Pentapati3 1Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; 2Department of Conservative Dentistry and Endodontics, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; 3Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaCorrespondence: Yogesh Chhaparwal, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India, Tel +91 9986454730, Email yogesh.chhaparwal@manipal.eduBackground: Lingual plate thickness, density, and proximity to the tooth are linked as risk factors for various complications associated with third molar extraction. The present study aimed to assess the lingual plate thickness, and density in the mandibular third molar region using cone beam computed tomography and to estimate its correlation with type and level of impaction, number of roots, age, and gender as the risk factorsMethods: This was a retrospective study on CBCT images of 648 mandibular third molars. The lingual plate thickness at three different root levels – cervical, mid-root, and apex along with the position of the tooth, number of roots, density of lingual plate, age, and gender were evaluated. The measurements were done on Invivo 5-Anatomage software. Statistical comparison of the categorical variables was done by Chi-square test, and Fisher’s exact test, and univariate and multivariate analysis were done using binomial logistic regression.Results: Lingual plate thickness of the third molars at the cervical, mid root, and apex were 1.28 mm, 1.42 mm and .01 mm (mean). A significantly higher proportion of subjects with thin lingual plates at mid-root (p-value=0.01) and apex (p-value=0.05) were in the 21– 30 age group. Lingual bone density was significantly associated with the thickness of the lingual plate at the mid-root. A significantly higher proportion of thinner lingual plates at the mid-root level were associated with mesioangularly placed third molars (p-value=0.002).Conclusion: Our study presented that lingual plate thickness has a strong association with age, angulation, and the number of roots. Knowledge about these risk factors is imperative during the management of third molar impactions.Keywords: lingual plate, third molar, bone density, mandible, cone-beam computed tomography

Abstract Background Site-specific transport of medicinal products to malignant cells and tissues is an intriguing area since it has an ability to safeguard healthy cells. Selective upregulation of folate receptors on colon cancer cells is usual. Consequently, folate receptors have become one of extensively studied target moieties for targeting the delivery of chemotherapeutics. Hence, the study aimed to anchor folic acid, chitosan and oxaliplatin to the functionalized nanotube (FA-CHI-FSWCNT-OXA) for targeting folate receptors on colon cancer cells. The purification process of single-walled carbon nanotubes (SWCNTs) involved the use of an ultrasonic-assisted acid digestion method. The developed complex was evaluated using FTIR, DSC, SEM, XRD and in vitro dissolution studies. SRB and MTT assays were used to assess in vitro cytotoxicity of oxaliplatin and FA-CHI-FSWCNT-OXA) against HT29 and COLO320DM cell lines. Further, progression of apoptosis in cells was investigated using flow cytometry. Results The FTIR results corroborated drug attachment over carbon nanotube (CNT), whereas the TEM results validated the nanosizing (1–300 nm) of the developed system. Drug entrapment in CNT was found to be 93.43 ± 1.65%, and in vitro drug release was found to be 94.73 ± 0.90% after 24 h. The complex reduced viability of 92.35 ± 0.942% cells than oxaliplatin’s 66.58 ± 0.38% inhibition, revealed by MTT assay. In the SRB assay, the developed system showed 91.22 ± 0.90% inhibition, whereas oxaliplatin showed 76.69 ± 0.52% inhibition against HT29 cells. Conclusions Conclusively, the developed system exhibited better cytotoxicity effects as compared with plain oxaliplatin. Our findings are suggestive of the potential development of CNT-anchored antineoplastic agents for target-specific delivery.

The COVID-19 pandemic caused disruptions in colorectal cancer (CRC) care by interrupting CRC screening across Canada, posing problems for program participants, patients, and physicians and no clear understanding of how provincial healthcare systems would adapt in the face of another pandemic or shock to the system. A nationwide online survey targeted to members of the National Colorectal Cancer Screening Network (NCCSN) using the SurveyMonkey platform was conducted to gain insight into the impact of the pandemic on CRC screening from March 2020 to March 2022 across all thirteen Canadian jurisdictions. The survey included 25 multiple-choice and free-text questions. Both quantitative and qualitative methods were used to analyze the data using Microsoft Excel and NVivo software. Twenty-one provincial and territorial representatives participated in the survey conducted between 13 May 2022 and 27 October 2022. All jurisdictions (100%) reported decreased screenings, including fecal immunochemical testing (FIT) or Fecal Occult Blood testing (FOBT) procedures, and subsequent diagnostic colonoscopies. The average wait time for colonoscopies due to a positive FIT/FOBT was 76 days. To mitigate the backlog and initiate an effective intervention plan, representatives highlighted some key points, including the importance of prioritizing high-risk patients. Survey results concluded that the COVID-19 pandemic impacted CRC screening across Canada. This landscape assessment can help inform intervention measures and policy-related solutions to create greater resilience for CRC screening in provincial and territorial healthcare systems.

Abstract This paper aims to introduce a custom-designed multiband planar inverted-F antenna (PIFA) suitable for automotive applications in LTE/5G schemes operating under 6 GHz, as well as Vehicle-to-Everything (V2X) communications. The PIFA antenna has a broad bandwidth capability, resonating from 950 MHz to 6 GHz. The proposed PIFA antenna is divided into three parts: the top, front, and back, resulting in a unique and effective antenna structure. The antenna is fabricated using a substrate made of FR4 material with a dielectric constant of 4.4. The whole measurements of the antenna are 54 × 38 × 25 mm3.The proposed PIFA antenna has been tested and has achieved a voltage standing wave ratio (VSWR) of less than 2 across the entire frequency range of 950 MHz to 6 GHz. Additionally, the maximum gain achieved by the antenna is 7.08 dBi at a frequency of 5.5 GHz, 6.81 dBi at 5.2 GHz, and 6.65 dBi at 5.9 GHz. The antenna also achieved a gain of 6.67 dBi at 3.8 GHz and a gain of 3.31 dBi at 1.7 GHz. Overall, this paper presents a well-designed and effective multiband PIFA antenna that is appropriate for use in vehicular applications. The antenna ability to cover a wide range of bandwidth and achieve high gain makes it an excellent candidate for use in LTE/5G systems and V2X communications.

Abstract Background Responsive and resilient strategies to reduce high rates of maternal and infant mortality and clinician shortages are needed in low- and middle-income countries (LMICs). Malawi has some of the highest maternal and infant mortality rates globally. Group healthcare is a service delivery model that integrates these strategies. Although primarily implemented during the prenatal period, its potential for improving both maternal and infant health outcomes during the postpartum period has not been realized. The purpose of this study was to adapt and co-design the prototype for an evidence-based group care model for the postpartum period using a human-centered design approach with key stakeholders in Malawi. Methods We completed steps of a framework guiding the use of human-centered design: 1) define the problem and assemble a team; 2) gather information through evidence and inspiration; 3) synthesize; and 4) intervention design: guiding principles and ideation. Qualitative methods were used to complete steps 2–4. In-depth interviews (n = 24), and incubator sessions (n = 6) that employed free listing, pile sorting and ranking were completed with key stakeholders. Data analysis consisted of content analysis of interviews and framework analysis for incubator sessions to produce the integrated group postpartum and well-child care model prototype. The fifth step is detailed in a separate paper. Results All stakeholders reported a desire to participate in and offer group care in the postpartum period. Stakeholders worked collaboratively to co-create the prototype that included a curriculum of health promotion topics and interactive activities and the service delivery structure. Health promotion topic priorities were hygiene, breastfeeding, family planning, nutrition, and mental health. The recommended schedule included 6 sessions corresponding with the child vaccination schedule over the 12-month postpartum period. Conclusions Using a human-centered design approach to adapt an evidence-based group care model in an LMIC, specifically Malawi, is feasible and acceptable to key stakeholders and resulted in a prototype curriculum and practical strategies for clinic implementation.

Abstract In the months of March-June, India experiences high daytime temperatures (Tmax), which sometimes lead to heatwave-like conditions over India. In this study, 10 different machine learning models are evaluated for their ability to predict the daily Tmax anomalies 10 days ahead in the months of March-June. Several model experiments were carried out to identify an optimal model to predict daily Tmax anomalies over India. The results indicate that the AdaBoost regressor with Multi-layer Perceptron as the base estimator is an optimal model to predict the Tmax anomalies over India in the months of March-June. The optimal model predictions are benchmarked against 10-day persistence predictions and the predictions from the Climate Forecast System (CFS) reforecast. The results indicate that the machine learning model skill is higher than persistence and comparable to CFS reforecast 10-day predictions in April and May. In March and June, the machine learning models have low skill scores and perform no better than persistence. These results indicate that the machine learning models are promising tools to predict the surface air maximum temperature anomalies over India in April and May and can complement predictions from more sophisticated numerical models.

Abstract Background Acquisition of psychomotor skills is of utmost importance for competent preclinical restorative dentistry. Recent advancements in haptic feedback technology have been incorporated into preclinical dental education to augment the conventional phantom head-based training. Objective This systematic review aims to assess the effectiveness of haptic feedback device, Simodont, in improving the skill development and learning outcomes of dental students during their preclinical training. Materials and methods Electronic databases Web of Science, Scopus, PubMed were searched for relevant studies since inception up until March, 2023. Only English language studies that assessed the effectiveness of haptic feedback devices in preclinical dental education were included. We excluded studies that did not use Simodont as the haptic feedback device or did not involve preclinical restorative work. Study quality was assessed using the revised Cochrane risk of bias tool and ROBINS-I. The primary goal of the study is to evaluate the efficacy of Simodont as a complementary training modality for dentistry students. Results Results from 9 high-quality studies were analyzed and synthesized to evaluate the overall impact of haptic feedback devices on various aspects of preclinical training. The studies were conducted on 826 undergraduate dental students enrolled in various years of their training across dental colleges and universities in different parts of the world. A majority of studies showed some concerns regarding risk of bias. Haptic feedback devices added a new layer to Virtual Reality (VR) through the perception of touch and force feedback. It assisted junior dental students improve their psychomotor skills and movement skills. Instantaneous feedback on the students' performance helped enhance their self-assessment and correction, and also eliminated the subjectivity of evaluation. Data derived from virtual simulators helped stratify dental students and predict their clinical performance, providing an opportunity to tailor the learning process to meet individual diversity in students' expertise. Conclusion Based on the limited evidence available, Simodont was effective in preclinical training of dental students, offering advantages such as unlimited reproducibility, objective evaluation of preparation by computer assessment, and cost reduction. And further studies are warranted to explore the incorporation of patient's oral environment simulation for better skill training.

Aim: Sarcopenia and skeletal muscle density (SMD) have been shown to be both predictive and prognostic marker in oncology. Advanced lung cancer inflammation index (ALI) has been shown to predict overall survival (OS) in small cell lung cancer (SCLC). Computed tomography (CT) enables skeletal muscle to be quantified, whereas body mass index (BMI) cannot accurately reflect body composition. The purpose was to evaluate the prognostic value of modified ALI (mALI) using CT-determined third lumbar vertebra (L3) muscle index beyond original ALI and see the interaction between sarcopenia, SMD, neutrophil-lymphocyte ratio (NLR), ALI and mALI at baseline and post 4 cycles of chemotherapy and their effects on OS and progress free survival (PFS) in patients with advanced non-SCLC (NSCLC). Methods: This retrospective study consisted of a total of 285 advanced NSCLC patients. The morphometric parameters such as SMD, skeletal muscle index (SMI) and fat-free mass (FFM) were measured by CT at the L3 vertebra. ALI was defined as BMI × serum albumin/NLR and mALI was defined as SMI × serum albumin/NLR. Results: Sarcopenia was observed in over 70% of patients across all BMI categories. Patients having sarcopenia suffered from a higher incidence of chemotherapeutic drug toxicities but this was not found to be statistically significant. Concordance was seen between ALI and mALI in the pre-treatment setting and this was statistically significant. A significant proportion of patients with poor ALI (90.9%), poor pre-chemotherapy mALI (91.3%) and poor post-chemotherapy mALI (89%) had poor NLR and each of them was statistically significant. Conclusions: In both univariate and multivariate analyses, this study demonstrated the statistical significance of sarcopenia, SMD, and mALI as predictive factors for OS. Additionally, sarcopenia and SMD were also found to be statistically significant factors in predicting PFS. These biomarkers could potentially help triage patients for active nutritional intervention for better outcomes.

Abstract Heat waves, and an increased number of warm days and nights, have become more prevalent in major agricultural regions of the world. Although well adapted to semi-arid regions, cotton is vulnerable to high temperatures, particularly during flowering and boll development. To maintain lint yield potential without compromising its quality under high-temperature stress, it is essential to understand the effects of heat stress on various stages of plant growth and development, and associated tolerance mechanisms. Despite ongoing efforts to gather data on the effects of heat stress on cotton growth and development, there remains a critical gap in understanding the distinct influence of high temperatures during the day and night on cotton yield and quality. Also, identifying mechanisms and target traits that induce greater high day and night temperature tolerance is essential for breeding climate-resilient cotton for future uncertain climates. To bridge these knowledge gaps, we embarked on a rigorous and comprehensive review of published literature, delving into the impact of heat stress on cotton yields and the consequential losses in fiber quality. This review encompasses information on the effects of heat stress on growth, physiological, and biochemical responses, fertilization, cotton yield, and quality. Additionally, we discuss management options for minimizing heat stress-induced damage, and the benefits of integrating conventional and genomics-assisted breeding for developing heat-tolerant cotton cultivars. Finally, future research areas that need to be addressed to develop heat-resilient cotton are proposed.

Abstract Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare and devastating childhood-onset lysosomal storage disease caused by complete loss of function of the lysosomal hydrolase α-N-acetylglucosaminidase. The lack of functional enzyme in MPS IIIB patients leads to the progressive accumulation of heparan sulfate throughout the body and triggers a cascade of neuroinflammatory and other biochemical processes ultimately resulting in severe mental impairment and early death in adolescence or young adulthood. The low prevalence and severity of the disease has necessitated the use of animal models to improve our knowledge of the pathophysiology and for the development of therapeutic treatments. In this study, we took a systematic approach to characterizing a classical mouse model of MPS IIIB. Using a series of histological, biochemical, proteomic and behavioral assays, we tested MPS IIIB mice at two stages: during the pre-symptomatic and early symptomatic phases of disease development, in order to validate previously described phenotypes, explore new mechanisms of disease pathology and uncover biomarkers for MPS IIIB. Along with previous findings, this study helps provide a deeper understanding of the pathology landscape of this rare disease with high unmet medical need and serves as an important resource to the scientific community.

Background: COVID-19 disease has posed unprecedented challenges to patients and healthcare systems worldwide. Diabetes increases risk of hospitalization, admission to ICU and mortality from COVID-19. Present study was conducted to understand impact of diabetes mellitus on mortality and other clinical outcomes of COVID-19. Methods: It was a retrospective study based on review of medical records of COVID-19 patients aged ≥18 years treated on in-patient basis at a tertiary hospital. Patients’ COVID disease severity and in-hospital outcomes, pre-existing comorbidities, course of disease during hospital stay, baseline glycaemic levels, laboratory findings and treatment provided at the hospital were noted. Results: Prevalence of DM was 26.8%. Severe COVID disease and mortality were significantly associated with DM. Systemic corticosteroids (92.7%), low molecular weight heparin (90.6%) and antiviral drug remdesevir (67.3%) were mainstay of treatment. d-dimer, CRP, LDH and Ferritin (Q2: 483ng/ml, 6.0mg/dl, 574.9U/L and 780.2 ng/ml respectively) were significantly elevated in diabetic COVID patients. Higher risk of severe COVID disease was found among patients with poor glycaemic control. Conclusion: Impaired glucose regulation in COVID-19 patients increases risk of mortality and morbidity in COVID-19. COVID patients with diabetes mellitus should be managed meticulously as per the standard guidelines to achieve good glycaemic control.

Background: With advent of ultrasound, fetal changes are efficiently illustrated by ultrasonography with the evolving parameters as indicators of intrauterine growth. Methods: A prospective study was conducted on pregnant women in second and third trimester presented to the Department of Radio Diagnosis, Navodaya Medical College Hospital and Research Centre, Raichur. Result: Study results showed that TCD and GA was highly correlated with BPD, FL, AC and HC with p-value < 0.0001. Conclusion: It was concluded that TCD and GA was well correlated with various ultrasonic parameters including BPD, FL, AC, HC and TCD. The correlation between GA and TCD in IUGR pregnancies was highly significant with (R2 =0.85).

The proposed antenna introduces a wideband double-resonance substrate-integrated waveguide (SIW) cavity-backed slot antenna with shorting vias. The antenna is compact and has a wide frequency range. By loading the SIW cavity slot with shorting pin/vias, the authors describe the mechanism of operation and electric field distributions of the double resonance antenna. By etching the HBT-CRS at the center of the cavity, which creates the dual modes. One is an upward shift in the lowest mode (TE 120 mode or TE 210 mode) and a downward shift in the highest mode (TE 320 modes/TE 230 modes), and these two are paired together. As a result, the fabricated antenna has a very large bandwidth and a strong sense of double resonance. The antenna is designed, and then prototypes are built and tested. The key benefits are compactness, low fabrication cost, performance, and ease of integration with planar circuitry. SIW antennas are impactful in present wireless communication systems. A simulated double resonance design antenna with a low profile of 0.05 λ0 (free-space wavelength) has a bandwidth of 1.854 GHz (frequency range varies from 12.58 - 14.38 GHz and fractional bandwidth of 13.93%) and a peak gain of 6.56 dBi across the whole bandwidth while measured bandwidth is 2 GHz (frequency range from 12.5 - 14.5 GHz and fractional bandwidth of 14.81%) and the gain over the entire bandwidth is 6.46 dBi. In addition, the antenna has outstanding unidirectional radiation characteristics for Ku band applications.

Faster and predictable osseointegration is crucial for the success of dental implants, especially in patients with compromised local or systemic conditions. Despite various surface modifications on the commercially available Titanium (Ti) dental implants, the bioactivity of Ti is still low. Thus, to achieve both biological and therapeutic activity on titanium surfaces, surface modification techniques such as titanium nanotubes have been studied as nanotube surfaces can hold therapeutic drugs and molecules. The main aim of the present research work is to study the early osseointegration around the novel Simvastatin drug eluting nanotubular dental implant. In the present research, the titanium nanotubes were fabricated on the screw-shaped dental implant surface and the Simvastatin drug was loaded into the nanotubes using the ultrasonication dip method. In vitro and In vivo studies were carried out on the modified dental implants. In vitro cell culture study reported enhanced osteogenic activity on the drug-loaded nanotube surface implants. The in vivo animal studies were evaluated by micro-CT, histopathology, and reverse torque removal analysis methods. The test results showed faster osseointegration with the strong interface on the Simvastatin drug-loaded implant surface at 4 weeks of healing as compared to the control implants.

Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells determines the fate of healing or inflammation. Although several reports have demonstrated that tissue regeneration depends on spatial and temporal regulation of the biophysical or biochemical microenvironment of the biomaterial, the underlying molecular mechanism behind immunomodulation is still under consideration for developing immunomodulatory scaffolds. Currently, most fabricated immunomodulatory platforms reported in the literature show regenerative capabilities of a particular tissue, for example, endogenous tissue (e.g., bone, muscle, heart, kidney, and lungs) or exogenous tissue (e.g., skin and eye). In this review, we briefly introduced the necessity of the 3D immunomodulatory scaffolds and nanomaterials, focusing on material properties and their interaction with macrophages for general readers. This review also provides a comprehensive summary of macrophage origin and taxonomy, their diverse functions, and various signal transduction pathways during biomaterial-macrophage interaction, which is particularly helpful for material scientists and clinicians for developing next-generation immunomodulatory scaffolds. From a clinical standpoint, we briefly discussed the role of 3D biomaterial scaffolds and/or nanomaterial composites for macrophage-assisted tissue engineering with a special focus on bone and associated tissues. Finally, a summary with expert opinion is presented to address the challenges and future necessity of 3D bioprinted immunomodulatory materials for tissue engineering.