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This paper discusses a methodology to improve the prevention processes of chronic diseases such as diabetes and strokes. The research motivation is to find a new methodological approach to design advanced Diagnostic and Therapeutic Care Pathways (PDTAs) based on the prediction of chronic disease using telemedicine technologies and machine learning (ML) data processing techniques. The aim is to decrease health risk and avoid hospitalizations through prevention. The proposed method defines a Process Mining Organization (PMO) model, managing risks using a PDTA structured to prevent chronic risk. Specifically, the data analysis is focused on stroke risk. First, we applied and compared the Random Forest (RF) and Gradient Boosted Trees (GBT) supervised algorithms to predict stroke risk, and then, the Fuzzy c-Means unsupervised algorithm to cluster information on the predicted results. The application of the proposed approach is able to increase the efficiency of healthcare human resources and drastically decrease care costs.