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Abstract High‐density neural recordings with superior spatiotemporal resolution powerfully unveil cellular‐scale neural communication, showing great promise in neural science, translational medicine, and clinical applications. To achieve such, many design and fabrication innovations enhanced the electrode, chip, or both for biocompatibility improvement, electrical performance upgrade, and size miniaturization, offering several thousands of recording sites. However, an enormous gap exists along the trajectory toward billions of recording sites for brain scale resolution, posing many more design challenges. This review tries to find possible insight into mitigating the gap by discussing the latest progress in high‐density electrodes and chips for neural recordings. It emphasizes the design, fabrication, bonding techniques, and in vivo performance optimization of high‐density electrodes. It discusses the promising opportunities for circuit‐level and architecture‐level multi‐channel chip design innovations. We expect that joint effort and close collaboration between high‐density electrodes and chips will pave the way to high‐resolution neural recording tools supporting cutting‐edge neuroscience discoveries and applications.

Introduction Problematic internet use among the elderly is an emerging area as previous studies focused more among the young people. Only a few studies focused on problematic internet use at the level of individual characteristics of older adults or on mitigating factors at the level of the older adult's family, ignoring family-level disruptive factors. Objective The purpose of study is to investigate the relationship between conflict with children and problematic internet use among the elderly, as well as the mediating mechanisms and boundary conditions of the relationship. Methods The valid sample of study composed of 428 older adults from 39 different villages and communities in central China. Data analyses were conducted by SPSS, MPLUS, and SmartPLS software. To test our hypotheses, we implement several quantitative methods, including confirmatory factor analysis (CFA), correlations analysis, and ordinary least squares (OLS) regression. Also, we employed partial least square structural equation modeling (PLS-SEM) for robustness testing. Results The results indicated that conflict with children was positively associated with problematic internet use of old people; psychological depression mediated the relationship between conflict with children and old adults’ problematic internet use; sociability moderated the effect of conflict with children on psychological depression; and living situation moderated the effect of psychological depression on problematic internet use among the elderly. Conclusion The current research improved the understanding of the mechanisms that produce problematic internet use among the elderly and helped prevent or reduce problematic internet use in older adults in terms of family support systems and individual ability characteristics.

The orbital angular momentum (OAM) of light has been implemented as an information carrier in OAM holography. Holographic information can be multiplexed in theoretical unbounded OAM channels, promoting the applications of optically addressable dynamic display and high-security optical encryption. However, the frame-rate of the dynamic extraction of the information reconstruction process in OAM holography is physically determined by the switching speed of the incident OAM states, which is currently below 30 Hz limited by refreshing rate of the phase-modulation spatial light modulator (SLM). Here, based on a cross convolution with the spatial frequency of the OAM-multiplexing hologram, the spatial frequencies of an elaborately-designed amplitude distribution, namely amplitude decoding key, has been adopted for the extraction of three-dimensional holographic information encoded in a specific OAM information channel. We experimentally demonstrated a dynamic extraction frame rate of 100 Hz from an OAM multiplexing hologram with 10 information channels indicated by individual OAM values from –50 to 50. The new concept of cross convolution theorem can even provide the potential of parallel reproduction and distribution of information encoded in many OAM channels at various positions which boosts the capacity of information processing far beyond the traditional decoding methods. Thus, our results provide a holographic paradigm for high-speed 3D information processing, paving an unprecedented way to achieve the high-capacity short-range optical communication system.

Previous studies have discussed the preconditions for peer service providers participation in value co-creation from the perspective of the platforms or the peer service providers themselves. However, little attention has been paid to the influence of customers. In the sharing economy, however, customers interact closely with peer service providers, and they have a major influence on the attitudes and behaviours of peer service providers. Based on resource conservation theory, this study uses three waves of tracking surveys and two experiments to investigate the impact of customer unfriendliness on the shared value creation of peer service providers. The results suggest that rude customers in the sharing economy reduce the value creation behaviour of peer service providers by increasing emotional exhaustion. Furthermore, self-efficacy in regulating negative emotions is found to buffer the mechanism by which customer incivility increases the likelihood of emotional exhaustion. Peer service providers with higher self-efficacy in negative emotion regulation have weaker such relationships. This research fills the gap of how customers influence the value creation behaviour of peer service providers in the sharing economy, identifies the potential negative impacts of customer incivility and increases the overall added value of the sharing economy.

Abstract Background The postoperative period is critical for a patient’s recovery, and postoperative hypotension, specifically, is associated with adverse clinical outcomes and significant harm to the patient. However, little is known about the association between postoperative hypotension in patients in the intensive care unit (ICU) after non-cardiac surgery, and morbidity and mortality, specifically among patients who did not experience intraoperative hypotension. The goal of this study was to assess the impact of postoperative hypotension at various absolute hemodynamic thresholds (≤ 75, ≤ 65 and ≤ 55 mmHg), in the absence of intraoperative hypotension (≤ 65 mmHg), on outcomes among patients in the ICU following non-cardiac surgery. Methods This multi-center retrospective cohort study included specific patient procedures from Optum® healthcare database for patients without intraoperative hypotension (MAP ≤ 65 mmHg) discharged to the ICU for ≥ 48 h after non-cardiac surgery with valid mean arterial pressure (MAP) readings. A total of 3185 procedures were included in the final cohort, and the association between postoperative hypotension and the primary outcome, 30-day major adverse cardiac or cerebrovascular events, was assessed. Secondary outcomes examined included all-cause 30- and 90-day mortality, 30-day acute myocardial infarction, 30-day acute ischemic stroke, 7-day acute kidney injury stage II/III and 7-day continuous renal replacement therapy/dialysis. Results Postoperative hypotension in the ICU was associated with an increased risk of 30-day major adverse cardiac or cerebrovascular events at MAP ≤ 65 mmHg (hazard ratio [HR] 1.52; 98.4% confidence interval [CI] 1.17–1.96) and ≤ 55 mmHg (HR 2.02, 98.4% CI 1.50–2.72). Mean arterial pressures of ≤ 65 mmHg and ≤ 55 mmHg were also associated with higher 30-day mortality (MAP ≤ 65 mmHg, [HR 1.56, 98.4% CI 1.22–2.00]; MAP ≤ 55 mmHg, [HR 1.97, 98.4% CI 1.48–2.60]) and 90-day mortality (MAP ≤ 65 mmHg, [HR 1.49, 98.4% CI 1.20–1.87]; MAP ≤ 55 mmHg, [HR 1.78, 98.4% CI 1.38–2.31]). Furthermore, we found an association between postoperative hypotension with MAP ≤ 55 mmHg and acute kidney injury stage II/III (HR 1.68, 98.4% CI 1.02–2.77). No associations were seen between postoperative hypotension and 30-day readmissions, 30-day acute myocardial infarction, 30-day acute ischemic stroke and 7-day continuous renal replacement therapy/dialysis for any MAP threshold. Conclusions Postoperative hypotension in critical care patients with MAP ≤ 65 mmHg is associated with adverse events even without experiencing intraoperative hypotension.

Background Aortic valve replacement (AVR) is a life‐saving treatment for patients with symptomatic severe aortic valve stenosis. We sought to determine whether transcatheter AVR has resulted in a more equitable treatment rate by race in the United States. Methods and Results A total of 32 853 patients with symptomatic severe aortic valve stenosis were retrospectively identified via Optum’s deidentified electronic health records database (2007–2017). AVR rates in non‐Hispanic Black and White patients were assessed in the year after diagnosis. Multivariate Fine‐Gray hazards models were used to evaluate the likelihood of AVR by race, with adjustment for patient factors and the managing cardiologist. Time‐trend and 1‐year symptomatic severe aortic valve stenosis survival analyses were also performed. From 2011 to 2016, the rate of AVR increased from 20.1% to 37.1%. Overall, Black individuals were less likely than Whites to receive AVR (22.9% versus 31.0%; unadjusted hazard ratio [HR], 0.70; 95% CI, 0.62–0.79; fully adjusted HR, 0.76; 95% CI, 0.67–0.85). Yet, during 2015 to 2016, AVR racial differences were attenuated (29.5% versus 35.2%; adjusted HR, 0.86; 95% CI, 0.74–1.02) because of greater uptake of transcatheter AVR in Blacks than Whites (53.4% of AVRs versus 47.3%; P=0.128). Untreated patients had significantly higher 1‐year mortality than those treated (adjusted HR, 0.57; 95% CI, 0.53–0.61), which was consistent by race (interaction P value=0.52). Conclusions Although transcatheter AVR has increased the use of AVR in the United States, treatment rates remain low. Black patients with symptomatic severe aortic valve stenosis were less likely than White patients to receive AVR, yet these differences have recently narrowed.

Objective: Although patient satisfaction is increasingly used to rate hospitals, it is unclear how patient satisfaction is associated with health outcomes. We sought to define the relationship of self-reported patient satisfaction and health outcomes. Design: Retrospective cross-sectional analysis using regression analyses and generalized linear modeling. Setting: Utilizing the Medical Expenditure Panel Survey Database (2010-2014), patients who had responses to survey questions related to satisfaction were identified. Participants: Among the 9166 patients, representing 106 million patients, satisfaction was rated as optimal (28.2%), average (61.1%), and poor (10.7%). Main Outcome Measures: We sought to define the relationship of self-reported patient satisfaction and health outcomes. Results: Patients who were younger, male, black/African American, with Medicaid insurance, as well as patients with lower socioeconomic status were more likely to report poor satisfaction (all P < .001). In the adjusted model, physical health score was not associated with an increased odds of poor satisfaction (1.42 95% confidence interval [CI]: 0.88-2.28); however, patients with a poor mental health score or ≥2 emergency department visits were more likely to report poor overall satisfaction (3.91, 95% CI: 2.34-6.5; 2.24, 95% CI: 1.48-3.38, respectively). Conclusion: Poor satisfaction was associated with certain unmodifiable patient-level characteristics, as well as mental health scores. These data suggest that patient satisfaction is a complex metric that can be affected by more than provider performance.

Abstract Background The Office of Naval Research (ONR) organized a STEM Challenge initiative to explore how intelligent tutoring systems (ITSs) can be developed in a reasonable amount of time to help students learn STEM topics. This competitive initiative sponsored four teams that separately developed systems that covered topics in mathematics, electronics, and dynamical systems. After the teams shared their progress at the conclusion of an 18-month period, the ONR decided to fund a joint applied project in the Navy that integrated those systems on the subject matter of electronic circuits. The University of Memphis took the lead in integrating these systems in an intelligent tutoring system called ElectronixTutor. This article describes the architecture of ElectronixTutor, the learning resources that feed into it, and the empirical findings that support the effectiveness of its constituent ITS learning resources. Results A fully integrated ElectronixTutor was developed that included several intelligent learning resources (AutoTutor, Dragoon, LearnForm, ASSISTments, BEETLE-II) as well as texts and videos. The architecture includes a student model that has (a) a common set of knowledge components on electronic circuits to which individual learning resources contribute and (b) a record of student performance on the knowledge components as well as a set of cognitive and non-cognitive attributes. There is a recommender system that uses the student model to guide the student on a small set of sensible next steps in their training. The individual components of ElectronixTutor have shown learning gains in previous decades of research. Conclusions The ElectronixTutor system successfully combines multiple empirically based components into one system to teach a STEM topic (electronics) to students. A prototype of this intelligent tutoring system has been developed and is currently being tested. ElectronixTutor is unique in its assembling a group of well-tested intelligent tutoring systems into a single integrated learning environment.

Objective To investigate the effect and mechanism of pterostilbene (Pte) on paraquat (PQ)-induced pulmonary fibrosis in rats. Methods The rats were randomly divided into control group, PQ group (intragastric administration of 50 mg/kg paraquat at one time), and low, medium and high dose of Pte intervention group (after 30 minutes of intragastric administration of PQ, 25, 50 and 100 mg/kg Pte were administered respectively. Once a day for 7 days). After 7 days of treatment, the morphology of lung tissue was evaluated by hematoxylin-eosin (HE) staining microscopy and pulmonary fibrosis was evaluated by Masson trichrome staining. The level of IL-1β, IL-6 and MIP-2 in bronchoalveolar lavage fluid (BALF) was determined by ELISA. MDA and SOD contents in lung tissues were detected with commercially available kit. The protein expression of E-cadherin, α-SMA, vimentin,Nrf2, NF-κB p65, NF-κB p65, TGF-β1, Smad3 and p-Smad3 in lung tissue was detected by Western blot. Results Compared with the control group, the injury degree of lung tissue, the score of pulmonary fibrosis, the level of IL-1β, IL-6 and MIP-2 in BALF, the content of MDA in lung tissue, the protein expression of α-SMA, vimentin and TGF-β1 and the phosphorylation level of NF-κB p65 and Smad3 protein in lung tissue were all significantly increased in PQ group (P＜0.05), while the content of SOD and the protein expression of E-cadherin and Nrf2 in lung tissue were significantly decreased (P＜0.05). After Pte intervention, the injury of lung tissue, the score of pulmonary fibrosis, the level of IL-1β, IL-6 and MIP-2 in BALF, the content of MDA in lung tissue, the protein expression of α-SMA, vimentin and TGF-β1 and the phosphorylation of NF-κB p65 and Smad3 protein in lung tissue were all significantly decreased in Pte group (P＜0.05), while the content of SOD and the protein expression of E-cadherin and Nrf2 in lung tissue were significantly increased (P＜0.05). Conclusions Pterostilbene may inhibit fibrosis progression by reducing oxidative stress and decrease of inflammatory response in the lung through activation of Nrf2 and inhibition of NF-κB and TGF-β1/Smad2/3 signaling pathways.