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The Kallintiri area (SW Byala Reka–Kechros Dome, Rhodope) hosts a polymetallic (critical, base, and precious metals) ore deposit, tectonically controlled by the late Eocene–Oligocene, top-to-SW Kallintiri Detachment System. The earliest structure associated with the Kallintiri Detachment is a ductile shear zone at the interface between the high-grade footwall gneisses of the Lower and Intermediate Rhodope Terranes. The detachment zone encompasses the uppermost part of the gneisses and the ultramylonitic Makri Unit marble. The marble is bound by a brittle–ductile shear zone at the base and a knife-sharp, low-angle normal fault at the roof, exhibiting considerable brecciation and ultracataclasite development. The hanging wall includes the Makri Unit phyllites and the overlying mid–late-Eocene–Oligocene supra-detachment sediments, which show syn-depositional slump structures and brittle deformation with low- and high-angle faulting and non-cohesive cataclasites. Extensive hydrothermal fluid circulation along the detachment zone and through NW tension gashes and high-angle faults led to pronounced silicification and ore deposition. Field observations and mineralogical and geochemical analyses revealed two primary types of ore mineralization spatially and temporally associated with different structures. Base and precious metals-rich ores are associated with the detachment, while Sb ore deposition is localized mostly within the NW-trending tension gashes and high-angle faults.

Background Valproic acid (VPA), a histone deacetylase inhibitor, has shown improved outcomes when used as a pharmaceutical intervention in animal studies of hemorrhage, septic shock, and combined injuries. This study was designed to investigate the ability of VPA to mitigate ischemia–reperfusion injury produced by prolonged tourniquet application to an extremity.Methods The ischemia–reperfusion model in anesthetized rats was established using hemorrhage and a 3-hour tourniquet application. VPA was administered intravenously prior to tourniquet wear and removal. Ischemia–reperfusion injury was evaluated by investigating pathway signaling, immune modulation of cytokine release, remote organ injury, and skeletal muscle function during convalescence.Results We found that VPA sustained Protein kinase B (Akt) phosphorylation and Insulin-like growth factor signaling and modulated the systemic release of interleukin (IL)-1β, tumor necrosis factor alpha, and IL-6 after 2 hours of limb reperfusion. Additionally, VPA attenuated a loss in glomerular filtration rate at 3 days after injury. Histological and functional evaluation of extremity skeletal muscle at 3, 7, and 21 days after injury, however, demonstrated no significant differences in myocytic degeneration, necrotic formation, and maximal isometric tetanic torque.Conclusions Our results demonstrate that VPA sustains early prosurvival cell signaling, reduces the inflammatory response, and improves renal function in a hemorrhage with prolonged ischemia and reperfusion model. However, these do not translate into meaningful preservation in limb function when applied as a pharmaceutical augmentation to tourniquet wear.Level of evidence IV.

Native iron has been identified in an active thermogenic travertine deposit, located at Ilia area (Euboea Island, Greece). The deposit is forming around a hot spring, which is part of a large active metallogenetic hydrothermal system depositing ore-bearing travertines. The native iron occurs in two shapes: nodules with diameter 0.4 and 0.45 cm, and angular grains with length up to tens of μm. The travertine laminae around the spherical/ovoid nodules grow smoothly, and the angular grains are trapped inside the pores of the travertine. Their mineral-chemistry is ultra-pure, containing, other than Fe, only Mn (0.34–0.38 wt.%) and Ni (≤0.05 wt.%). After evaluating all the possible environments where native iron has been reported up until today and taking under consideration all the available data concerning the study area, we propose two possible scenarios: (i) Ilia’s native iron has a magmatic/hydrothermal origin i.e., it is a deep product near the magmatic chamber or a peripheral cooling igneous body that was transferred during the early stages of the geothermal field evolution, from high temperature, reduced gas-rich fluids and deposited along with other metals in permeable structural zones, at shallow levels. Later on, it was remobilized and mechanically transferred and precipitated at the Ilia’s thermogenic travertine by the active lower temperatures geothermal fluids; (ii) the native iron at Ilia is remobilized from deep seated ophiolitic rocks, originated initially from reduced fluids during serpentinization processes; however, its mechanical transport seems less probable. The native iron mineral-chemistry, morphology and the presence of the other mineral phases in the same thermogenic travertine support both hypotheses.

The ophiolitic rocks of the Attic-Cycladic crystalline belt are considered of key importance for understanding the Mesozoic tectonic evolution of the Aegean region. Unresolved questions concern their tectono-stratigraphic relationships across the region. The mode of occurrence of the Cycladic ophiolites varies, as they appear as: (a) dismembered blocks (olistoliths) within the supra-detachment units of Paros and Naxos; (b) mélange formations in the upper structural unit of western Samos and Skyros; and (c) meta-ophiolitic mélange in the Cycladic Blueschist Unit (CBU) from central Samos. The trace element geochemistry and Pb-Sr-Nd isotopes of the mafic ophiolitic rocks indicate four geochemical groups: (a) the upper unit metabasites from Paros and western Samos (Kallithea) display an evolved basaltic composition (Mg# 40.2–59.6), with low Zr/Nb values (5–16) and high Ce/Y values (1.3 to 2.6) compared to MORB, indicating island-arc tholeiite affinities; (b) Naxos upper unit metabasalts show spider diagrams patterns indicating ocean island basalt (OIB-type) affinities; (c) Central Samos metagabbros (CBU) are primitive rocks with Back-Arc Basin basalt affinities; (d) the Skyros metadolerites and Tinos (Mt Tsiknias) and S. Evia (CBU) metagabbros, cluster as a separate geochemical group; they exhibit high MgO values (>10 wt %), very low TiO2 values (0.1–0.2 wt %), Y and Yb, and depleted trace element N-MORB normalized patterns, similar to volcanic rocks formed in modern oceanic fore-arc settings, such as boninites. A combination of the Pb- and Sr-isotopic compositions of Cycladic metabasites indicate that the Pb and Sr incorporated in the Cycladic ophiolites correspond to mixtures of magmatic fluids with seawater (206Pb/204Pb = 18.51–18.80; 207Pb/204Pb = 15.59–15.7; 208Pb/204Pb = 39.03–39.80 and initial 87Sr/86Sr80 = 0.705–0.707). Furthermore, peridotite relicts from Samos, Paros, and Naxos—irrespective of the structural unit—display chemical affinities of ocean floor peridotites formed in a supra-subduction zone. The characteristics of harzburgite relicts in Cycladic serpentinites and Skyros indicate a highly residual nature of the mantle source. Geochemical data from this study shed further light on the complex structure of the oceanic lithosphere from which the Cycladic ophiolites originated.