Search

Duodenal-type follicular lymphoma （D-FL） is a rare disease. At present，biological characteristics and clinical progression of D-FL are still unclear. In this article，three patients with D-FLwere reported，with an average age of 51 years. All patients were diagnosed during physical examination. Two patients had no complaints，and one patient reported upper abdominal discomfort and fatigue.After admission，all patients underwent CT and gastroscopy，and the diagnosis of D-FL was finally confirmed by pathological biopsy. Two patients refused treatment because of no symptoms，and the disease did not progress during follow-up. One patient received R2 regimen （obinutuzumab + lenalidomide） chemotherapy for more than 1 year. Upon the submission date，heoccasionally felt epigastric discomfort，fatigue and night sweats. The diagnosis and treatment of these three patients suggest that biological behaviors of D-FL are constantly indolent. Regular follow-up observation can be considered for asymptomatic patients，and active treatment can be performed for symptomatic young patients if they accept. At present，there is no guideline or consensus on the diagnosis and treatment of D-FL at home and abroad. The diagnosis and treatment process of three patients are reported，aiming to deepen clinicians’ understanding of diagnosis and treatment of D-FL.