1. Genetic Susceptibility to Chronic Kidney Disease: Links, Risks and Management
- Author
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Sawaf H, Gudura TT, Dorobisz S, Sandy D, Wang X, and Bobart SA
- Subjects
genetics ,chronic kidney disease ,end stage kidney disease ,cystic kidney disease ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Hanny Sawaf,1 Tariku T Gudura,1 Sylvester Dorobisz,1 Dianne Sandy,2 Xiangling Wang,1 Shane A Bobart2 1Department of Kidney Medicine, Cleveland Clinic, Cleveland, OH, USA; 2Department of Kidney Medicine, Cleveland Clinic Florida, Weston, FL, USACorrespondence: Shane A Bobart, Department of Kidney Medicine, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA, Email bobarts@ccf.orgAbstract: Chronic kidney disease (CKD) is associated with significant morbidity and mortality worldwide. In recent years, our understanding of genetic causes of CKD has expanded significantly with several renal conditions having been identified. This review discusses the current landscape of genetic kidney disease and their potential treatment options. This review will focus on cystic kidney disease, glomerular disease with genetic associations, congenital anomalies of kidneys and urinary tract (CAKUT), autosomal dominant-tubulointerstitial kidney disease (ADTKD), inherited nephrolithiasis and nephrocalcinosis.Keywords: genetics, chronic kidney disease, end stage kidney disease, cystic kidney disease
- Published
- 2023