1. Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D
- Author
-
Lennart Hermanussen, Sibylle Lampalzer, Jan-Hendrik Bockmann, Annerose E. Ziegler, Felix Piecha, Maura Dandri, Sven Pischke, Friedrich Haag, Ansgar W. Lohse, Marc Lütgehetmann, Christina Weiler-Normann, and Julian Schulze zur Wiesch
- Subjects
hepatitis D virus ,hepatitis B virus ,autoimmune hepatitis ,autoantibodies ,viral hepatitis ,Medicine (General) ,R5-920 - Abstract
Infections with hepatotropic viruses are associated with various immune phenomena. Hepatitis D virus (HDV) causes the most severe form of viral hepatitis. However, few recent data are available on non-disease-specific and non-organ-specific antibody (NOSA) titers and immunoglobulin G (IgG) levels in chronic hepatitis D (CHD) patients. Here, we examined the NOSA titers and IgG levels of 40 patients with CHD and different disease courses and compared them to 70 patients with chronic hepatitis B (CHB) infection. 43% of CHD patients had previously undergone treatment with pegylated interferon-α (IFN-α). The antibody display of 46 untreated patients diagnosed with autoimmune hepatitis (AIH) was used as a reference. The frequency of elevated NOSA titers (CHD 69% vs. CHB 43%, p
- Published
- 2023
- Full Text
- View/download PDF