1. Unforeseen complications of pembrolizumab in breast reconstruction post-mastectomy
- Author
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Murad Aldarayseh, Sohail Singh Sodhi, Gamal Musleh, Dyuti Kumar, and Michelle Cholankeril
- Subjects
pembrolizumab ,breast reconstruction ,breast cancer ,Medicine - Abstract
A 53-year-old post-menopausal Indian female presented with invasive ductal carcinoma, treated with neoadjuvant chemotherapy and pembrolizumab due to a PD-L1 combined positive score of 5. Following a right mastectomy and axillary dissection, she received a breast expander and AlloDerm™ graft. After resuming pembrolizumab and paclitaxel postoperatively, she developed severe breast redness and high-grade fever, necessitating expander removal due to suspected pembrolizumab-induced complications. This case underscores the unique and severe adverse effects of pembrolizumab on breast reconstruction, highlighting the need for careful monitoring and management in patients undergoing similar treatments.
- Published
- 2024
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