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In this paper, we use the sub-ODE method to analyze soliton solutions for the renowned nonlinear Klein-Gordon model (NLKGM). This method provides a variety of soliton solutions, including three positive solitons, three Jacobian elliptic function solutions, bright solitons, dark solitons, periodic solitons, rational solitons and hyperbolic function solutions. Applications for these solitons can be found in optical communication, fiber optic sensors, plasma physics, Bose-Einstein condensation and other areas. We also study some numerical solutions by using forward, backward, and central difference techniques. Moreover, we discuss variational integrators (VIs) using the projection technique for NLKGM. We develop a numerical solution for NLKGM using the discrete Euler lagrange equation, the Lagrangian and the Euler lagrange equation. At the end, in various dimensions, covering 3D, 2D, and contour, we will also plot several graphs for the obtained NLKGM solutions. A contour plot is a type of graphic representation that displays a three-dimensional surface on a two-dimensional plane by using contour lines. Each contour line in the plotted function represents one of the function's constant values, mapping the function's value across the plane. This model has been studied across multiple soliton solutions using various methods in the open literature, but this model for VIs and finite deference scheme (FDS) is the first time it has been studied. Within the various numerical techniques accessible for solving Hamiltonian systems, variational integrators distinguish themselves because of their symplectic quality. Here are some of the symplectic properties: symplectic orthogonality, energy conservation, area preservation, and structure preservation.

This study aimed to evaluate the visual-spatiotemporal co-registration of the real and virtual objects’ movement dynamics by designing a low-cost, physics-based virtual reality (VR) system that provides actual cutaneous and kinesthetic haptic feedback of an object instead of using computer-generated haptic feedback. Twelve healthy participants performed three human-robot collaborative (HRC) sequential pick-and-place lifting tasks while both motion capture and VR systems, respectively, traced the movement of the real and virtual objects simultaneously. We used an iterative closest point algorithm to transform and align the 3D coordinates of VR point clouds with the 3D coordinates of the motion capture system. We introduced a new method to calculate and analyze the precision of visual and spatiotemporal co-registration between virtual and real objects. Results showed a high correlation ( $r >$ 0.96) between real and virtual objects’ movement dynamics and linear and angular co-registration errors of less than 5 cm and 8°, respectively. The trend also revealed a low temporal registration error of < 12 ms and was only found along the vertical axis. The visual registration data indicated that using real objects to provide cutaneous and kinesthetic haptics in the VR setting enhanced the users’ overall proprioception and visuomotor functions.

BACKGROUND: In the intensive care unit (ICU), complex medical conditions require specialized care; the threat of antibiotic resistance is significant due to frequent antibiotic use. This study investigates the pivotal role of culture sensitivity testing in shaping antibiotic prescription practices and patient outcomes in ICUs. MATERIALS AND METHODS: By using a prospective observational-analytical design, medical data from 640 patients at a Karachi hospital for one year in 2022 were utilized. The study focused on antibiotic therapy, including empiric and targeted approaches, culture sensitivity testing, the use of the APACHE scale for mortality prediction, and changes in antibiotic regimens based on culture reports. Statistical analysis involved Fisher’s Exact and ANOVA tests. RESULT: The age category above 60 emerged with the highest survivorship. Contrary to expectations, age did not seem to correlate significantly with mortality rates. Staphylococcus species was the most prevalent microorganism in this study, disproportionately affecting nonsurvivors 66.7%. The clinical profile comparison between survivors and nonsurvivors offered a multifaceted perspective, with significant differences in vital parameters such as temperature, heart rate, respiratory rate, urine output, FiO2, mean arterial pH, and blood sugar levels. Survivors (44.60%) underwent complete antibiotic regimen changes, a strategy for improved patient outcomes. CONCLUSIONS: Complex antibiotic combinations were prescribed for broad clinical conditions. These insights pave the way for future research on antibiotic stewardship in ICUs, navigating more effective and targeted treatments.

Background: Donation after circulatory death with thoracoabdominal normothermic regional perfusion (DCD-NRP) for cardiac transplant has promising results, though data for lung transplant is lacking. This study evaluates lung transplant outcomes using DCD-NRP allografts. Methods: All patients who underwent lung transplantation (LT) from June 1, 2020, to July 5, 2023, at a single institution were evaluated. Recipients received organs from DCD-NRP or brain dead (control) donors (donation after brain death (DBD)). All DCD-NRP were adult, primary bilateral LT (BLT) without preoperative extracorporeal membrane oxygenation (ECMO). Inclusion criteria for controls were age >18 years, BLT, no preoperative ECMO, and primary transplantation. Comparison was separated by LT or heart-lung transplant (HLT). The primary outcome was primary graft dysfunction (PGD) grade 3 at 72 hours. Results: There were 8 LT and 3 HLT in the DCD-NRP cohort, and 138 BLT and 7 HL DBD controls. PGD grade 3 at 72 hours was 0% in the entire DCD-NRP cohort (vs control: 9.4% LT and 0% HLT). There were no statistically significant differences in donor and recipient characteristics, though DCD-NRP HLT had significantly shorter ischemic time (85 vs 200 minutes, p

Purpose To evaluate the Visual Outcome in Diabetic Retinopathy with Macular Oedema after Combined Therapy with Intravitreal Avastin (Bevacizumab) and Retinal Photocoagulation. Material and Methods The study included a total of 142 eyes in 142 patients with diabetic macular oedema. All eyes were treated with intravitreal bevacizumab followed by laser photocoagulation .Visual outcome was measured in terms of changes in visual acuity (logMAR) at I month and 3 months after treatment and central macular thickness using spectral domain Ocular Coherence Tomography (OCT) at 3 months after treatment. Results Visual acuity improved from the mean best corrected visual a cuity (BCVA) log (MAR) of 0.9678 ± 0.2306 at baseline to 0.8928 ± 0.2516 at first visit and then 0.7831 ± 0.2866 at final visit in all 142 patients. OCT determined central macular thickness changed from a mean value of 624 ± 151 microns at first visit to 478 ± 141 microns at final visit in all studied subject. Conclusion Combined therapy with intravitreal bevacizumab and laser photocoagulation has a role in stabilizing the retinal anatomy and reducing retinal edema both in NPDR (Non proliferative diabetic retinopathy) and PDR (Proliferative diabetic retinopathy) with macular oedema. The decrease in the central macular thickness is also associated with a significant improvement in BCVA.

Abstract Background In older people living with frailty, polypharmacy can lead to preventable harm like adverse drug reactions and hospitalization. Deprescribing is a strategy to reduce problematic polypharmacy. All stakeholders should be actively involved in developing a person‐centred deprescribing process that involves shared decision‐making. Objective To co‐design an intervention, supported by a logic model, to increase the engagement of older people living with frailty in the process of deprescribing. Design Experience‐based co‐design is an approach to service improvement, which uses service users and providers to identify problems and design solutions. This was used to create a person‐centred intervention with the potential to improve the quality and outcomes of the deprescribing process. A ‘trigger film’ showing older people talking about their healthcare experiences was created and facilitated discussions about current problems in the deprescribing process. Problems were then prioritized and appropriate solutions were developed. The review located the solutions in the context of current processes and procedures. An ideal care pathway and a complex intervention to deliver better care were developed. Setting and Participants Older people living with frailty, their informal carers and professionals living and/or working in West Yorkshire, England, UK. Deprescribing was considered in the context of primary care. Results The current deprescribing process differed from an ideal pathway. A complex intervention containing seven elements was required to move towards the ideal pathway. Three of these elements were prototyped and four still need development. The complex intervention responded to priorities about (a) clarity for older people about what was happening at all stages in the deprescribing process and (b) the quality of one‐to‐one consultations. Conclusions Priorities for improving the current deprescribing process were successfully identified. Solutions were developed and structured as a complex intervention. Further work is underway to (a) complete the prototyping of the intervention and (b) conduct feasibility testing. Patient or Public Contribution Older people living with frailty (and their informal carers) have made a central contribution, as collaborators, to ensure that a complex intervention has the greatest possible potential to enhance the experience of deprescribing medicines.

Aim: To assess the changes in frequency parameters of STN-DBS stimulation over 6 months required to optimize gait in PD patients. Methods: It's a single center, open label longitudinal study of PD patients after STN-DBS with gait disorders. Gait assessment using stand–walk–sit (SWS) test and freezing of gait (FOG) scores were done at baseline and after 6 months. Gait was assessed in five frequencies settings, that is, 60 Hz, 90 Hz, 130 Hz, 180 Hz and stimulation “OFF” during medication ON state. Voltage was maintained. Results: Fifteen post-deep brain stimulation (DBS) patients were included. Mean duration after surgery was 3.73 ± 2.82 years. In SWS and FOG at baseline, five patients have good response at 180 Hz frequency, five at 130 Hz, one at 90 Hz, two patients at 60 Hz, one both 60 and 90 Hz, and one at both 90 and 180 HZ. And after 6 months out of the 13 patients who were able to perform the test, four patients had good response at 180 Hz frequency, four at 130 Hz, two at 90 Hz, one each for 60 Hz and battery OFF state, and one for both 130 Hz and 180 Hz. At 6 months, four patients had good response at the same frequency as baseline, while 11 patients have change in frequency from baseline. Conclusion: Optimal frequency for gait varies in patients—both low and high frequency may be useful. Optimal frequency for improving gait changes over period of time. Regular assessment and changing frequency may improve gait after DBS.

Piezoelectric materials have attracted considerable attention over the last two decades because many technologies utilize their core properties of piezoelectric materials. Previous applications consisted of bulk structures; however, a shift towards better performance and a more simplified and compatible fabrication method are required. Aluminum nitride (AlN) is a material that fits these criteria; it has a non-centrosymmetric crystal structure with a polarized c-axis and exhibits piezoelectric properties. Furthermore, it has an added benefit as the fabrication process of AIN is compatible with complementary metal–oxide semiconductor technology. This has led to a rapid increase in the adoption and interest in AlN-based devices. In this review, the crystal structure of AlN and its piezoelectric properties are compared with those of aluminum scandium nitride. Subsequently, functional devices such as consumer-based devices, telecommunication-based devices, industrial-related applications, and medical applications are presented. Finally, a summary and discussion of the future AlN research are presented.

Diabetes has become a pandemic as the number of diabetic people continues to rise globally. Being a heterogeneous disease, it has different manifestations and associated complications in different individuals like diabetic nephropathy, neuropathy, retinopathy, and others. With the advent of science and technology, this era desperately requires increasing the pace of embracing precision medicine and tailoring of drug treatment based on the genetic composition of individuals. It has been previously established that response to antidiabetic drugs, like biguanides, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and others, depending on variations in their transporter genes, metabolizing genes, genes involved in their action, etc. Responsiveness of these drugs also relies on epigenetic factors, including histone modifications, miRNAs, and DNA methylation, as well as environmental factors and the lifestyle of an individual. For precision medicine to make its way into clinical procedures and come into execution, all these factors must be reckoned with. This review provides an insight into several factors oscillating around the idea of precision medicine in type-2 diabetes mellitus.

Right heart thrombus represents medical emergency as it is associated with acute pulmonary embolism. Right heart thrombus can manifest acutely in a dramatic fashion as cardiac arrest. Bedside echocardiography is a key to rapid diagnosis and allow early intervention. We report a case of elderly female who was admitted to our hospital after a mechanical fall and found to have hip fracture. Despite an initial uncomplicated course, she experienced cardiopulmonary arrest with right heart clot in transit identified on transesophageal echocardiography (TEE). We highlight the utility of point-of-care ultrasound as well as use of TEE to establish cause of cardiopulmonary arrest.

Objective: Tumor-induced osteomalacia (TIO) is a rare osteomalacia characterized by paraneoplastic secretion of fibroblast growth factor 23. Concomitant occurrence of TIO during pregnancy is rarer still. Our objective was to report a young patient with debilitating fractures diagnosed with TIO who became pregnant and subsequently had her tumor localized by gallium-68 (Ga-68) DOTATATE positron emission tomography/magnetic resonance imaging (PET/MRI). Case Report: A 28 year-old woman with a 2-year history of stress fractures was found to have the following: (1) alkaline phosphatase level, 220 (reference range, 30-95) U/L; (2) phosphorus level, 2.1 (2.5-5.0) mg/dL; (3) 1,25-dihydroxyvitamin D3 level,

The higher losses of fruits and vegetables during post-harvest handling are a serious matter for any country whose economy is based on agriculture. The products of this plant are a significant source of horticultural produce storage used for the control of different post-harvest losses, which include diseases as well as microorganisms. Bio-coatings may be used as a better alternative to the synthetic chemicals. The impact of edible coating on the quality and storage life of mango (cv. ‘Anwar Rataul’) fruit was investigated by harvesting the fruits at a firm green stage of physiological maturity and coating them with corn oil, peanut oil, sunflower oil, soya bean oil, and animal fat. The uncoated and coated fruits were stored at 25 °C and the relative humidity (RH) was 75%. The fruits were analyzed for physicochemical quality attributes during storage at 0 (harvest time), 5, 10, 15, 20, and 25 days. The data showed that most of the parameters were affected significantly by the materials of coating and storage intervals (P ≤ 0.05). The fruits coated with animal fat had significantly superior fruit color, taste, aroma, firmness, total sugar content, and acidity of fruit juice, total soluble solids, and ascorbic acid content, as well as delayed ripening. Animal fat-coated fruits retained titratable acidity, ascorbic acid content (mg.100g-1) and fruit firmness (kg.cm-2) with minimal disease incidence, and weight loss (%), whereas uncoated fruits did not retain all quality attributes and deteriorated after 20 days of storage. In conclusion, mango fruits could be coated with animal fat and stored for up to 25 days without deterioration in quality.

This paper examines the propagation of M-shape solitons and their interactions with kink waves to the (2 + 1)-dimensional integrable Schwarz-Korteweg-de Vries (ISKdV) problem by applying the symbolic computation with ansatz functions technique and logarithmic transformation. The governing model usually appears in the nonlinear shallow water waves and fluid mechanics. We discuss various nonlinear waves like multiwave solutions (MSs), homoclinic breather (HB), M-shape solitons, single exponential form (one-kink), and double exponential form (two-kink). These waves have lot of applications in fluid dynamics, nonlinear optics, chemical reaction networks, biological systems, climate science, and material science. We also study interaction among M-shape solitons with kink wave. At the end, we discuss the stability characteristics of all solutions.

This article studies diverse forms of lump-type solutions for coupled nonlinear generalized Zakharov equations (CNL-GZEs) in plasma physics through an appropriate transformation approach and bilinear equations. By utilizing the positive quadratic assumption in the bilinear equation, the lump-type solutions are derived. Similarly, by employing a single exponential transformation in the bilinear equation, the lump one-soliton solutions are derived. Furthermore, by choosing the double exponential ansatz in the bilinear equation, the lump two-soliton solutions are found. Interaction behaviors are observed and we also establish a few new solutions in various dimensions (3D and contour). Furthermore, we compute rogue-wave solutions and lump periodic solutions by employing proper hyperbolic and trigonometric functions.

In this article, we consider the improved perturbed nonlinear Schrödinger Equation (IP-NLSE) with dual power law nonlinearity, which arises in optical fibers and photovoltaic-photo-refractive materials. We found grey and black optical solitons of the governing equation by means of a suitable complex envelope ansatz solution. By using the Chupin Liu’s theorem (CLT) for the grey and black solitons, we evaluated new categories of combined optical soliton (COS) solutions to the IP-NLSE. The propagation behaviors for homoclinic breathers (HB), multiwaves and M-shape solitons will be analytically examined. All new analytical solutions will be found by an ansatz function scheme and suitable transformations. Multiwave solitons have been reported by using a three-waves technique. Furthermore, two kinds of interactions for M-shape soliton through exponential functions will be examined.

The present study was conducted to evaluate the effect of maturity stages on the physicochemical characteristics of grapefruit (Citrus paradisi cv. ‘Shamber Tarnab’) under storage conditions for 60 days at ambient temperature (16±1 °C with 55-60% relative humidity). Grapefruits were harvested at different maturity stages, namely mature green (MG) and full ripe (FR). The fruits of both stages were assessed for different physical quality parameters at 15 days interval. The experimental results showed that ascorbic acid content, titratable acidity, fruit firmness, percent disease incidence was higher at FR stage. In contrast, weight loss, percent juice content, total soluble solid (TSS), and TSS/acid ratio at MG (mature green) were lower than that of FR fruits. Regarding storage durations, the fruit firmness, titratable acidity, percent juice content, ascorbic acid content decreased significantly, whilst total soluble solid, TSS/Acid ratio, weight loss, and percent disease incidence increased significantly with the extension of storage duration from 0 to 60 days. As concerned to its interactive effects, the highest ascorbic acid content, titratable acidity, percent juice content, and maximum fruit firmness were observed in fresh grapefruit, harvested at (MG) mature green stages, whereas the maximum total soluble solid, percent disease incidence, and TSS/Acid ratio were recorded in fruit harvested at (FR) full ripe stage, stored for 60 days at room temperature. Similarly, the Pearson’s Correlation Analysis (p> 0.05) of grapefruit was positive effect for most of the quality traits of grapefruit at different storage durations and maturity stages. It was concluded that grapefruit could be harvested at the mature green stage (MG) for sustaining quality attributes up to 60 days of storage at room temperature.

Mucormycosis is a rare fungal infection caused by fungi of the order Mucorales. The rhino-cerebral form of mucormycosis is most commonly seen in patients with diabetes mellitus, whereas pulmonary mucormycosis is a rare manifestation in patients with hematological malignancy and transplant recipients. We report a case of a 40-year-old male, with history of poorly controlled diabetes, who presented to the emergency room with a one-week history of hemoptysis. Computed Tomography (CT) of the chest was concerning for a lung mass or abscess. Flexible bronchoscopy revealed an endobronchial lesion that was biopsied with a cryoprobe. Histopathologic examination showed non-septate right-angle branching hyphae, typical of mucormycosis. He underwent surgical resection of the right middle and lower lobes and treatment with antimycotic agents with a complete recovery. This case highlights the importance of early histopathological diagnosis of pulmonary mucormycosis in preventing a fatal outcome.

We explore stochastic–fractional Drinfel’d–Sokolov–Wilson (SFDSW) equations for some wave solutions such as the cross-kink rational wave solution, periodic cross-rational wave solution and homoclinic breather wave solution. We also examine some M-shaped solutions such as the M-shaped rational solution, M-shaped rational solution with one and two kink waves. We also derive the M-shaped interaction with rogue and kink waves and the M-shaped interaction with periodic and kink waves. This model is used in mathematical physics, surface physics, plasma physics, population dynamics and applied sciences. Moreover, we also show our results graphically in different dimensions. We obtain these solutions under some constraint conditions.

We explore various analytical rational solutions with symbolic computation using the ansatz transformation functions. We gain a variety of rational solutions such as M-shaped rational solutions (MSRs), periodic cross-rationals (PCRs), multi-wave solutions, rational kink cross-solutions (RKCs), and homoclinic breather solutions (HBs), and by using the appropriate values for the relevant parameters, their dynamics are visualized in figures. Additionally, two different types of interactions between MSRs and kink waves are analyzed. Furthermore, we examine the stability of the obtained solutions and create a corresponding table. We analyze the stability of these solutions and the movement role of the wave by making graphs as two-dimensional, three-dimensional and density graphs as well as contour visual and stream plots.

This manuscript consist of diverse forms of lump: lump one stripe, lump two stripe, generalized breathers, Akhmediev breather, multiwave, M-shaped rational and rogue wave solutions for the complex cubic quintic Ginzburg Landau (CQGL) equation with intrapulse Raman scattering (IRS) via appropriate transformations approach. Furthermore, it includes homoclinic, Ma and Kuznetsov-Ma breather and their relating rogue waves and some interactional solutions, including an interactional approach with the help of the double exponential function. We have elaborated the kink cross-rational (KCR) solutions and periodic cross-rational (KCR) solutions with their graphical slots. We have also constituted some of our solutions in distinct dimensions by means of 3D and contours profiles to anticipate the wave propagation. Parameter domains are delineated in which these exact localized soliton solutions exit in the proposed model.

This present article explores the transversal magnetized flow of a viscous fluid. The flow is confined to a vertical wall, saturated in permeable medium, along with ramped wall temperature. In this study, the conjugate impact of heat and mass transfer with slip and non-slip conditions are considered in the velocity field and energy equation. The dimensionless Atangana-Baleanu fractional governing equations are derived with Laplace transformation. Computational results are expressed graphically with the effect of various physical parameters. Comparative graphical analysis of the Atangana-Baleanu derivative for temperature, concentration and velocity field, with slip and non-slip impact, shows that the memory effects of the Atangana-Baleanu derivative are better than the results that exist in the literature.

Purpose: Institutional theory is a reasonable explanation for the motives of corporate social responsibility (CSR) behaviours (e.g. corporate green innovation). The existing literature defines institutional pressure as threats for legitimacy when firms operate within a country or a region; one area that has received little attention is the situation when a firm extends its operations across borders to pursue internationalisation. The study investigates the impact of outward foreign direct investment (OFDI) on green innovation at the firm level. Design/methodology/approach: The zero-inflated negative binomial regression models are estimated to analyse the data collected from 2065 manufacturing enterprises listed in China during 2007–2017 (n = 14 129). Green innovation is measured by the number of green patents, according to the World Intellectual Property Organization (WIPO) International Patent Classification (IPC) Green Inventory. Findings/results: The findings show that OFDI is positively associated with green innovation for emerging market enterprises (EMEs). Furthermore, compared with investment in emerging economies, OFDI in developed economies has a stronger positive relationship with corporate green innovation. The positive effect of OFDI on corporate green innovation will be higher for EMEs located in sub-national regions (i.e., province of the home country) with lower levels of institutional development. Practical implications: Emerging market enterprises should overcome organisational inertia and compete in a broader market to enhance their awareness and ability of green innovation. Originality/value: This article contributes to the existing literature by exploring institutional pressure faced by EMEs when they operate overseas (e.g. OFDI) can play a significant role in influencing green innovation, and enriches our understanding of EMEs’ inclination towards CSR (e.g. green innovation) in the context of internationalisation.

Background: Pain is common in patients with chronic kidney disease (CKD). Analgesics may be appropriate for some CKD patients. Objectives: To determine the prevalence of overall analgesic use and the use of different types of analgesics including acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), adjuvants, and opioids in patients with CKD. Design: Systematic review and meta-analysis. Setting: Interventional and observational studies presenting data from 2000 or later. Exclusion criteria included acute kidney injury or studies that limited the study population to a specific cause, symptom, and/or comorbidity. Patients: Adults with stage 3-5 CKD including dialysis patients and those managed conservatively without dialysis. Measurements: Data extracted included title, first author, design, country, year of data collection, publication year, mean age, stage of CKD, prevalence of analgesic use, and the types of analgesics prescribed. Methods: Databases searched included MEDLINE, CINAHL, EMBASE, and Cochrane Library. Two reviewers independently screened all titles and abstracts, assessed potentially relevant articles, and extracted data. We estimated pooled prevalence of analgesic use and the I 2 statistic was computed to measure heterogeneity. Random-effects models were used to account for variations in study design and sample populations, and a double arcsine transformation of the prevalence variables was used to accommodate potential overweighting of studies with very large or very small prevalence measurements. Sensitivity analyses were performed to determine the magnitude of publication bias and assess possible sources of heterogeneity. Results: Forty studies were included in the analysis. The prevalence of overall analgesic use in the random-effects model was 50.8%. The prevalence of acetaminophen, NSAIDs, and adjuvant use was 27.5%, 17.2%, and 23.4%, respectively, while the prevalence of opioid use was 23.8%. Due to the possibility of publication bias, the actual prevalence of acetaminophen use in patients with advanced CKD may be substantially lower than this meta-analysis indicates. A trim-and-fill analysis decreased the pooled prevalence estimate of acetaminophen use to 5.4%. The prevalence rate for opioid use was highly influenced by 2 large US studies. When these were removed, the estimated prevalence decreased to 17.3%. Limitations: There was a lack of detailed information regarding the analgesic regimen (such as specific analgesics used within each class and inconsistent accounting for patients on multiple drugs and the use of over-the-counter analgesics such as acetaminophen and NSAIDs), patient characteristics, type of pain being treated, and the outcomes of treatment. Data on adjuvant use were very limited. These results, therefore, must be interpreted with caution. Conclusions: There was tremendous variability in the prescribing patterns of both nonopioid and opioid analgesics within and between countries suggesting widespread uncertainty about the optimal pharmacological approach to treating pain. Further research that incorporates robust reporting of analgesic regimens and links prescribing patterns to clinical outcomes is needed to guide optimal clinical practice.

Terpenes are the largest class of natural products with extensive structural diversity and are widely used as pharmaceuticals, herbicides, flavourings, fragrances, and biofuels. While they have mostly been isolated from plants and fungi, the availability and analysis of bacterial genome sequence data indicates that bacteria also possess many putative terpene synthase genes. In this study, we further explore this potential for terpene synthase activity in bacteria. Twenty two potential class I terpene synthase genes (TSs) were selected to represent the full sequence diversity of bacterial synthase candidates and recombinantly expressed in E. coli. Terpene synthase activity was detected for 15 of these enzymes, and included mono-, sesqui- and diterpene synthase activities. A number of confirmed sesquiterpene synthases also exhibited promiscuous monoterpene synthase activity, suggesting that bacteria are potentially a richer source of monoterpene synthase activity then previously assumed. Several terpenoid products not previously detected in bacteria were identified, including aromandendrene, acora-3,7(14)-diene and longiborneol. Overall, we have identified promiscuous terpene synthases in bacteria and demonstrated that terpene synthases with substrate promiscuity are widely distributed in nature, forming a rich resource for engineering terpene biosynthetic pathways for biotechnology.

In this work, we study a time-fractional ion sound and Langmuir waves system (FISLWS) with Atangana–Baleanu derivative (ABD). We use a fractional ABD operator to transform our system into an ODE. We investigate multiwaves, periodic cross-kink, rational, and interaction solutions by the combination of rational, trigonometric, and various bilinear functions. Furthermore, 3D, 2D, and relevant contour plots are presented for the natural evolution of the gained solutions under the selection of proper parameters.

In this paper, we study the improved perturbed nonlinear Schrödinger equation with cubic quadratic nonlinearity (IPNLSE-CQN) to describe the propagation properties of nonlinear periodic waves (PW) in fiber optics. We obtain the chirped periodic waves (CPW) with some Jacobi elliptic functions (JEF) and also obtain some solitary waves (SW) such as dark, bright, hyperbolic, singular and periodic solitons. The nonlinear chirp associated with each of these optical solitons was observed to be dependent on the pulse intensity. The graphical behavior of these waves will also be displayed.

Abstract The suite of biological catalysts found in Nature has the potential to contribute immensely to scientific advancements, ranging from industrial biotechnology to innovations in bioenergy and medical intervention. The endeavour to obtain a catalyst of choice is, however, wrought with challenges. Herein we report the design of a structure-based annotation system for the identification of functionally similar enzymes from diverse sequence backgrounds. Focusing on an enzymatic activity with demonstrated synthetic and therapeutic relevance, five new phenylalanine ammonia lyase (PAL) enzymes were discovered and characterised with respect to their potential applications. The variation and novelty of various desirable traits seen in these previously uncharacterised enzymes demonstrates the importance of effective sequence annotation in unlocking the potential diversity that Nature provides in the search for tailored biological tools. This new method has commercial relevance as a strategy for assaying the ‘evolvability’ of certain enzyme features, thus streamlining and informing protein engineering efforts.

Objectives: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. Methods: This case-control study was carried out between May 2013 and November 2014 at the Era’s Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (

Vitamin E is the major lipid-soluble component in the cell antioxidant defence system and is exclusively obtained from the diet. It has numerous important roles within the body because of its antioxidant activity. Oxidation has been linked to numerous possible conditions and diseases, including cancer, ageing, arthritis and cataracts; vitamin E has been shown to be effective against these. Platelet hyperaggregation, which can lead to atherosclerosis, may also be prevented by vitamin E; additionally, it also helps to reduce the production of prostaglandins such as thromboxane, which cause platelet clumping. The current literature review discusses the functions and roles of vitamin E in human health and some diseases as well as the consequences of vitamin E deficiency. The main focus of the review is on the tocopherol class of the vitamers.

Vitamin E is the major lipid-soluble component in the cell antioxidant defence system and is exclusively obtained from the diet. It has numerous important roles within the body because of its antioxidant activity. Oxidation has been linked to numerous possible conditions and diseases, including cancer, ageing, arthritis and cataracts; vitamin E has been shown to be effective against these. Platelet hyperaggregation, which can lead to atherosclerosis, may also be prevented by vitamin E; additionally, it also helps to reduce the production of prostaglandins such as thromboxane, which cause platelet clumping. The current literature review discusses the functions and roles of vitamin E in human health and some diseases as well as the consequences of vitamin E deficiency. The main focus of the review is on the tocopherol class of the vitamers.

Leadership and management training during pathology residency have been identified repeatedly by employers as insufficient. A 1-month rotation in clinical laboratory management (CLM) was created for third-year pathology residents. We report on our experience and assess the value of this rotation. The rotation was one-half observational and one-half active. The observational component involved being a member of department and laboratory service line leadership, both at the departmental and institutional level. Observational participation enabled learning of both the content and principles of leadership and management activities. The active half of the rotation was performance of a project intended to advance the strategic trajectory of the department and laboratory service line. In our program that matriculates 4 residents per year, 20 residents participated from April 2010 through December 2015. Their projects either activated a new priority area or helped propel an existing strategic priority forward. Of the 16 resident graduates who had obtained their first employment or a fellowship position, 9 responded to an assessment survey. The majority of respondents (5/9) felt that the rotation significantly contributed to their ability to compete for a fellowship or their first employment position. The top reported benefits of the rotation included people management; communication with staff, departmental, and institutional leadership; and involvement in department and institutional meetings and task groups. Our 5-year experience demonstrates both the successful principles by which the CLM rotation can be established and the high value of this rotation to residency graduates.

Physico-chemical characteristics of two Bauhinia seed varieties (B. variegata and B. linnaei), were evaluated for commercial exploration. Physico-chemical characteristics of the oils for both varieties were demonstrated and mean values found to be refractive index (40 °C) 1.4589 and 1.4588, peroxide value 1.9 and 2.4 (meq O2 / kg of oil), iodine value 84.5 and 92.2 (g of I2/100g of oil), saponification number 191.3 and 195.5 (mg of KOH /g of oil), free fatty acids 0.6% and 0.9%, unsaponifiable matter 0.9% and 1.2% and color (1 in. cell), 2.2-2.9R + 30.0-25.0Y, respectively. Linoleic 42.1 and 45.8 %, oleic 13.4 and 12.6%, stearic 17.5 and 18.8% and palmitic 22.1 and 16.8% were the main fatty acids in the crude seed oils. Minor amounts of palmitoleic, margaric, linolenic, arachidic, behenic, eicosapentaenoic and nervonic acid were also identified. The composition of defatted seed residue of B. variegata and B. linnaei were found as: protein 41.9% and 38.6%, oil 18.0%, and 17.4% ash 4.8% and 4.2%, moisture 6.7% and 6.3%, fiber 6.9% and 7.3% and total carbohydrate 28.4% and 33.8%, respectively. Proximate and fatty acid composition of both Bauhinia varieties were found to be almost similar. It was concluded that Bauhinia seed is a rich source of linoleic acid and could be explored for commercial uses.

Objectives: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. Methods: This case-control study was carried out between May 2013 and November 2014 at the Era’s Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (

The objective of the current study is analyze linear and nonlinear time–space fractional Black–Scholes models via modified homotopy perturbation method (m-HPM). In current investigation, memory effects in financial markets are explored through fractional derivative in Caputo sense. The effectiveness of proposed methodology is checked numerically by finding residual errors and presented in tables. These tables also provide a benchmark for the comparison with already existing results in literature. Furthermore, solutions are graphically analyzed via 3D and contour plots across a range of parameters under varying market conditions. Analysis confirms the efficiency of m-HPM for predicting solutions of time–space fractional Black–Scholes models. The current study can contribute in understanding the applications of fractional calculus in finance, and can be a valuable computational tool for pricing financial derivatives in fractional environments.

A major challenging proffered study rely on the inquisitive optimization of entropy together with thermal as well as mass transportation towards the chemically reactive 3-D Prandtl liquid under consideration of applied magnetic field, variable thermal conductivity and also diffusivity, hall current together with ion slip features, viscous dissipation and heat generation. Moreover, in present research study, model such as Cattaneo Christov heat flux was implemented in order to explore the thermal relaxation characteristics. By employing correspondence transformations, the system of modeled equations modified into non-linear ODEs system. The Optimal Homotopy Analysis methodology (OHAM) was adopted to solve the proffered problem. The influential arising constraints demeanor within both velocities (horizontal as well as vertical), temperature and concentration profiles were discussed and also shown graphically. Moreover, outcomes of diverse parameters were also examined and presented graphically within the entropy formation rate and also Bejan number. The effects of implanted factors across the drag force, the rate of thermal as well as mass transportation are accessible in current study via tables and validate the obtained results. Both velocity profiles (horizontal as well as vertical) decreased for increment in Hartman number whilst opposite demeanor seen for other considered constraints. Temperature profile drops for Prandtl number and elastic constraints whereas enhanced for other influential considered parameters whilst concentration profile augmented with Prandtl number. Present problem novelty relies on the modeling of comprehensive system of equations which modified into nonlinear ODEs. In order to obtain the solution numerically, technique such as Optimal Homotopy was opted.

Abstract Background Stability during early postnatal life in preterm infants is related to better outcomes. Although vital signs are monitored continuously in Neonatal Intensive Care Unites, this monitoring does not include all physiological parameters nor data such as movement patterns. Although there are scattered sources of data, there is no centralized data hub for neonates information. Results We have created the first neonate data hub for easy and interactive access to upload or download postural, physiological, and medical data of neonates: NeoVault. NeoVault is a platform that provides access to information through two interfaces: 1) via a Web interface (designed for medical personnel, data scientists, researchers); and 2) via a RESTful API (Application Programming Interfaces) -designed for developers-, aiming to integrate access to information into third-party applications. The web access allows searching and filtering according to specific parameters, visualization of data through graphs and images, and generation of datasets in CSV format. Access through the RESTful API is described in OpenAPI, enabling access to information from any device, facilitating it in an interoperable format. Currently, it contains nearly 800,000 postural records and 3.000 physiological data entries. The physiological and postural data stored for each neonate in NeoVault are collected through the NRP (Neonates Recording Platform) tool, which allows for the automatic and reliable collection of data. Conclusion NeoVault is an open platform for simple access to postural, physiological, and medical data of neonates that can be utilized by researchers, data scientists, medical personnel, and programmers. It enables integration into third-party applications and the generation of customized datasets.

Silver nanoparticles (AgNPs) were synthesized using a sustainable green approach utilizing deodorizer distillates of canola (CODD) and soybean oil (SODD) as both reducing and capping agents. This synthesis approach resulted in the formation of pale-yellow colored CODD-AgNPs and SODD-AgNPs, which was confirmed by distinctive absorption peaks at 420 nm and 408 nm, respectively via Ultraviolet-Visible (UV–Vis) spectroscopy. Fourier Transform Infrared (FTIR) analysis provided insights into the functional group interactions between CODD and SODD with their AgNPs. X-ray diffraction (XRD) confirmed the face-centered cubic lattice structure of both CODD-AgNPs and SODD-AgNPs. Further characterization via Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM) revealed the sizes, shapes, and surface morphologies of CODD-AgNPs and SODD-AgNPs. Assessment of antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method demonstrated superior radical scavenging efficacy by CODD-AgNPs (IC50 value 1.07±0.04 µg/mL) and SODD-AgNPs (IC50 value 1.14±0.23 µg/mL) compared to CODD and SODD. Evaluation of antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) via disc diffusion method revealed potent antibacterial activities of CODD-AgNPs and SODD-AgNPs at 100 µg/mL concentration, surpassing the antibacterial efficacy of CODD and SODD. Furthermore, CODD-AgNPs and SODD-AgNPs exhibited significant anti-inflammatory potential at 500 µg/mL concentration, with IC50 values of 187.2 ± 1.28 µg/mL and 203.9 ± 2.08 µg/mL, respectively, highlighting their potential therapeutic applications. In conclusion, this study demonstrates the effective utilization of CODD and SODD in synthesizing AgNPs with enhanced biological functionalities, making them promising candidates for various biomedical applications.

OBJECTIVE: To evaluate acute stroke care services in Sindh province of Pakistan. METHODS: This cross-sectional descriptive study, conducted from January to May 2024, assessed stroke care services in hospitals across Sindh, Pakistan. The study included hospitals that admitted more than one stroke patient per month and excluded facilities such as maternity homes and rehabilitation centers. Data were collected via structured proformas from hospital administrators through phone and email, focusing on stroke admissions, acute services, and rehabilitation capabilities. Informed consent was obtained, and ethical approval was granted by the Shifa International Hospital Ethical Committee. Data analysis utilized SPSS version 20 for continuous and categorical variables. RESULTS: Among the 34 surveyed hospitals, 15(44.1%) treated 1 to 10 stroke patients monthly, and 14 (41.2%) admitted over 300 patients annually. Neurologists were on staff in 15(44.1%) of hospitals, and 13 (38.2%) had stroke-trained physicians available 24/7. CT brain scans were accessible 24/7 in 23 (67.6%) of hospitals, with 19(55.9%) prioritizing these scans for stroke patients. Stroke units and 24/7 availability of intravenous tissue plasminogen activator (TPA) were available in 07 (20.6%) of hospitals only. Inpatient rehabilitation facilities were available in 21(61.8%) of hospitals, and 13 (38.2%) collaborated with external rehabilitation centers. Community stroke awareness programs were established in 12 (35.3%) of hospitals, and 09 (26.5%) had designed stroke prevention programs. CONCLUSION: The study highlights significant gaps in acute stroke care services in Sindh, Pakistan, emphasizing the need for improved access to thrombolytic therapy, specialized training, and community awareness programs.

Abstract Background Gallbladder cancer (GBC) is an infrequent type of malignant neoplasm worldwide. There are a number of risk factors that increase a person's likelihood of developing GBC. Gallbladder inflammatory (GID) diseases including cholelithiasis increase the risk of GBC, and this is further complicated by the fact that Helicobacter pylori (H. pylori) infection is extremely common in gastrointestinal tract in India. Since both miR 499 and H. pylori infection are found to be linked with tumor progression and metastasis, therefore there is a possibility that H. pylori might be involved in inflammation via dysregulation of miR 499. The study was designed to investigate the association of miR 499 expressions with H. pylori infection and their correlation with clinicopathological parameters of GBC. Material and methods The hundred three tissue samples used in this study are categorized into GID (n = 55) and GBC (n = 48). The expression of miR-499 was examined by using the Livak method for relative gene expression analysis. The presence/absence of H. pylori infection was examined by RT-PCR (Liferiver Helicobacter pylori RT-PCR Kit). Results Helicobacter pylori infection and GBC/GID cases were not significantly correlated. Decreased expression of miR 499 was observed in GBC (1.6 fold) as compared to GID patients (P

Objective This paper introduces RemoteHealthConnect , a novel web-based healthcare system designed to enable healthcare professionals to monitor patients remotely with enhanced efficacy. Central to our system is its integration with the Vitaliti™ wearable, equipped with biosensors for real-time vital signs monitoring. RemoteHealthConnect distinguishes itself by offering advanced, custom visualizations for interactive engagement with medical data, facilitating rapid clinical decision-making through intuitive access to vital signs and trends. The primary research question we sought to answer was: ‘Which design of vital sign visualizations is most effective in improving intuitive and rapid understanding for healthcare practitioners?’ Methods An iterative agile/SCRUM methodology was employed in the design and development of RemoteHealthConnect . We describe the architectural design of our web-based application, data visualization techniques, and user interface design. A user interface/user experience (UI/UX) study was conducted to assess the efficacy of our system. Results The usability study revealed the system's capacity to translate complex bedside data into accessible, real-world visualizations, promoting efficient pattern recognition and anomaly detection. This is crucial for enhancing clinician performance, regardless of the patient's location. The paper further details a usability study involving healthcare practitioners to ascertain RemoteHealthConnect's efficacy. The System Usability Scale (SUS) assessment yielded a score of 71.5, indicating high usability. This score is significant, positioning our system above the average usability threshold for healthcare technologies, and suggesting it as a valuable tool for remote patient monitoring. Conclusion Our web-based healthcare system and findings from the usability study contribute to the domains of Mobile Health (mHealth) and e-Health by advancing remote monitoring capabilities and offering a promising avenue for healthcare IT to improve patient care and clinician workflow.

The pandemic of COVID-19, due to the SARS-CoV-2 virus, has significantly impacted global health. Understanding the dynamics of immunity, both natural and vaccine-induced, is crucial for public health strategies. The study aimed to determine the seroprevalence of SARS-CoV-2 antibodies among clinical laboratory workers and its relationship with previous exposure to infection and vaccination. This was a prospective observational study conducted at the chemical Pathology section of Dow Diagnostic Research and Reference Laboratory (DDRRL), Dow University of Health Sciences, Karachi, Sindh, Pakistan from 1st January to 30th December 2021. Following ethical approval, 80 clinical laboratory workers provided informed consent to participate. Blood samples were collected and tested for SARS-CoV-2 IgG antibodies. The baseline demographic and clinical information was recorded, and conducted follow-up antibody tests six months later. The mean age of the participants was 37.7 years, with a standard deviation of 9.42. There were 46 males (57.5%) and 34 females (42.5%) in the study. Half of the participants (50%) had been vaccinated, with 35% receiving a single dose and 15% receiving both doses. 71.3% of the participants had comorbidities. SARS-CoV-2 antibodies were found to be reactive in 50% of the participants. The study also found significant associations between antibody presence and prior COVID-19 infection, vaccination status, contact history with COVID-19 patients, and prior history of hospitalization (p < 0.05). The study compared the initial and post-booster antibody levels among three groups of subjects (vaccinated, vaccinated with no prior COVID-19 infection, and non-vaccinated with prior COVID-19 infection), and found that antibody levels were significantly high in vaccinated subjects and non-vaccinated subjects with prior COVID-19 infection (p-value < 0.05). A significant difference was observed in antibody titers among subjects with prior history of vaccination and COVID-19 infection. In conclusion both natural infection and vaccination may induce antibodies against SARS-CoV-2 infection.

The pseudoplastic fluids have wide range of applications in industrial areas including cyclone separation, bearings, paper fibre separation, heat exchangers and also in food industry. In this regard, the current manuscript investigates the impact of transverse magnetic field on thin pseudo-plastic film flow on a vertical wall in a fuzzy (uncertain) environment. The uncertainty in a model is characterized through triangular fuzzy numbers (TFNs) along with [Formula: see text]-cut approach, which is computationally effective in capturing the uncertainties in physical phenomena. This results in the modelling of highly nonlinear fuzzified problem. For solution and analysis purposes, Runge–Kutta Fehlberg (RKF) is utilized. Also, RKF solutions are validated by comparing them to homotopy perturbation solutions in the current manuscript. The impact of [Formula: see text]-cut, and fluid parameters including non-Newtonian parameter β, magnetic field M and Stoke's number [Formula: see text] on the upper and lower velocity profiles are captured and analysed numerically and graphically. Analysis reveals that velocity profile decreases with an increase in applied magnetic field at upper and lower bounds. Also, increase in [Formula: see text] and β increases the velocity profile at lower bound, while inverse behaviour is recorded in the case of upper bound. The results also indicate that as [Formula: see text] goes from 0 to 1, the crisp solution always lies between upper and lower profiles, and becomes coherent at 1. Moreover, all fuzzy level set values of [Formula: see text] satisfy the fuzzy solution in the form of TFN.

The present work investigates mass and heat transport in non-Newtonian Sisko fluid past a three-dimensional bi-directional stretched heated surface with MHD effect, heat radiation, Joule warming, variable thermic conductivity, and temperature-dependent diffusivity. Comprehension the intricate relationships amongst mass and heat transfer in Sisko fluid across various magnetic field and radiation conditions requires an understanding of this model. It offers information on how to best optimize industrial operations where controlling fluid behavior and thermal characteristics is crucial, such as cooling systems and polymer extrusion. The difficulty is derived from resembling coupled nonlinear PDEs by engaging boundary layer theory and transforming them into systems of ODEs by applying suitable similarity transformations. The nonlinear converted ODEs have been solved using OHAT (optimal homotopy analysis technique) and the results are presented via graphs and tables. The performed analysis shows that escalating values of fluid parameter shows shear-thinning behavior and as a result fluid velocity upsurges. It is observed through findings that the velocity spectrum strengthens along the x-axis and y-axis concerning the Sisko fluid factor ( A ) . The thermal appearance exhibits improved behavior with higher thermal conductivity ( ε ) levels. Moreover, the thermal profile indicates enhanced behavior given the enrichment in Eckert number Ec and Radiation factor R . Previous research indicates that no comprehensive studies have been carried out to examine mass, heat transfer with changing thermal conductivity, diffusive coefficient variation, radiation warmth, and Joule heating for the two-way extended transport of the Sisko nanofluid. This study fills up that void.

In current paper, we considered the 3-D occurrence of magneto Williamson fluid subjected to linear penetrating expanding sheet. The Williamson liquid is taken into account under the essence of bio convection bordering with Joule heating, heat production. Moreover, Brownian movement combined with thermophoresis diffusion was also analyzed in current study. Central PDEs are modified into system of ODEs on the basis of appropriate similarity transformation utilization. For solution purpose, an optimal approach namely HAM was opted. The critical review based on all involved multifarious constraints across the non- dimensional velocity contour ( along x − axes and also y − axes ) , energy and concentration distribution. Moreover, across the motile organism distribution was also conducted graphically and depicts total covenant with the former published research work. The drag force effect, Nusselt number, Sherwood number, and motile organism density in tabular form is also proposed in this study. Moreover, Motile organism profile graphically demonstrates decreased demeanor for considered bio convection Lewis number, Peclet number, and also temperature difference constraint whereas results of motile organism density augmented in tabular version for the considered bio convection Lewis number, Peclet number, and also temperature difference constraint.

Water and nitrogen (N) are recognized as the primary determinants influencing the development and output of winter wheat. They affect the growth of winter wheat not only through their own changes, but also through their interaction. The translocation and accumulation of pre- and post-anthesis assimilates (including dry matter and N) are important physiological processes in winter wheat, which are closely related to the resource use efficiency and yield. However, a dearth of research exists that examines the complex interplay between varying water levels, especially severe water deficit, and N deficiency levels on the growth dynamics of winter wheat. The purpose of this study was to quantify and compare the effects of different degrees of water deficit and N interaction on assimilate translocation, water and N use efficiency and yield of winter wheat. A four-year long-term field experiment conducted under the rain-out shelter including four irrigation and two N levels was launched during 2019–2023. This method avoided the impact of precipitation on water treatment and helped to achieve serious water deficit treatment. The findings indicated that the higher N application improved the wheat's ability by 49.6 % - 362.3 % to utilize the available soil water. The pre- and post-anthesis translocation and accumulation of assimilates (including dry matter and N) in winter wheat increase alongside elevated levels of water and N application, except under severe water deficit treatment. Plants under mild to moderate water deficit were better able to translocate the pre-anthesis assimilates. However, the severe water deficit hindered the re-translocation of assimilates before anthesis. Providing additional N during periods of severe water scarcity leads to a 13.4 % - 44.7 % reduction in water use efficiency (WUE). Furthermore, both the irrigation water use efficiency and WUE diminished by 10.3 % - 60.5 % and 4.5 % - 41.4 % with higher levels of irrigation, while improved by 24.4 % - 48.2 % and 12.6 % - 39.4 % with higher N application rates. Conversely, N partial factor productivity and N use efficiency followed the opposite trend. Similar to WUE, increasing N application under severe water deficit would result in a yield reduction of 38.7 %. The reduction in crop yield resulting from severe water stress was primarily ascribed to the decline in the kernels number per spike (up to 74.9 %), with the reduction in spike number per unit area following closely behind (up to 29.1 %). This integrated approach, combining resource use efficiency with a detailed assessment of assimilate dynamics, provides a holistic view of how water and N management strategies impact winter wheat performance. The findings will offer precise insights for developing targeted irrigation and N scheduling strategies for sustaining both winter wheat production and environmental sustainability.

Abstract:: Oil blending is the method of choice used worldwide to improve oxidative stability and nutritional value. There is no such edible oil/fat that meets all the recommendations from the health point of view. The fatty acid composition of vegetable oils decides the fate of the oil. Pure single oil is unable to provide a balanced amount of fatty acids (FAs) required/recommended on a daily intake basis. Blending oils/fats is an appropriate procedure of physically mixing multiple oils in suitable proportions which may provide functional lipids with improved antioxidant potential and desirable physical and chemical properties. This review piled up the accessible data on the blending of diverse oils/fats in the combination of binary, ternary, quaternary, or other types of oils into a single blended oil. Blending can be found very convincing towards appropriate FA profile, enhancement in physicochemical characteristics, and augmented stability for the period of storage or when used as cooking/frying processes which could ultimately serve as an effectual dietary intervention towards the health protectiveness.