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Thanks to its excellent climate and varied agroecological zones, Nepal has been a significant player in the global rose market. The geographical variety of the nation makes it possible to grow roses all year long, making it a desirable location for rose export and cultivation. The production and export of roses have significantly increased in recent years. The rose trade has increased in Nepal for several reasons. Investment in the industry has been stimulated by government measures to support floriculture and offer incentives to rose farmers. Additionally, the effective distribution of roses to domestic and foreign markets has been made possible by better transportation infrastructure. The growth of the global market has greatly aided the development of Nepal's rose industry. The growth of rose cultivation in Nepal has significantly impacted the economy and employment. It is a good source of revenue through internal sales, export, and other activities that provide value addition. The sector creates direct farm jobs while local communities benefit from indirect employment in supporting industries. In addition, there is increased job opportunities due to seasonal spikes in demand. Rose exports have expanded due to a rise in demand for Nepali roses, particularly in European markets and nearby nations like India. The favorable trade agreements Nepal has with several nations have helped to increase its exports even more. But issues still exist in the rose trade sector. Since maintaining consistent quality is necessary to compete in the international market, quality control and standardization continue to be areas of concern. The rose business in Nepal is also vulnerable to changes in global demand and competition from other nations that grow roses. Further expansion of the industry will help it overcome problems like limited technology and training hence leading to its fast development; this calls for government support as well as market expansion. In conclusion, the rose trade environment in Nepal is a fluid and changing one. Due to favorable circumstances, government assistance, and global demand, the sector has seen significant expansion. Continuous efforts in quality control, market diversification, and innovation are necessary to maintain and grow this sector. The rose trade in Nepal has the potential to significantly boost the nation's agricultural exports while promoting economic growth in rural areas.

The interest in hadron therapy is growing fast thanks to the latest technological advances in accelerators and delivery technologies, to the development of more and more efficient and comprehensive treatment planning tools, and due to its increasing clinical adoption proving its efficacy. A precise and reliable beam quality assessment and an accurate and effective inclusion of the biological effectiveness of different radiation qualities are fundamental to exploit at best its advantages with respect to conventional radiotherapy. Currently, in clinical practice, the quality assurance (QA) is carried out by means of conventional dosimetry, while the biological effectiveness of the radiation is taken into account considering the Relative Biological Effectiveness (RBE). The RBE is considered a constant value for protons and it is estimated as a function of the absorbed dose in case of carbon ions. In this framework, microdosimetry could bring a significant improvement to both QA and RBE estimation. By measuring the energy deposited by the radiation into cellular or sub-cellular volumes, microdosimetry could provide a unique characterisation of the beam quality on one hand, and a direct link to radiobiology on the other. Different detectors have been developed for microdosimetry, from the more conventional tissue equivalent proportional counter (TEPC), silicon-based and diamond-based solid-state detectors, to ΔE-E telescope detectors, gas electrons multiplier (GEM), hybrid microdosimeters and a micro-bolometer based on Superconducting QUantum Interference Device (SQUID) technology. However, because of their different advantages and drawbacks, a standard device and an accredited experimental methodology have not been unequivocally identified yet. The establishment of accepted microdosimetry standard protocols and code of practice is needed before the technique could be employed in clinical practice. Hoping to help creating a solid ground on which future research, development and collaborations could be planned and inspired, a comprehensive state of the art of the detector technologies developed for microdosimetry is presented in this review, discussing their use in clinical hadron therapy conditions and considering their advantages and drawbacks.

Measurements in the stray radiation field from a proton therapy pencil beam at energies 70 and 146 MeV were performed using microdosimetric tissue-equivalent proportional counters (TEPCs). The detector volumes were filled with a propane-based tissue-equivalent gas at low pressure simulating a mean chord length of 2 μm in tissue. Investigations were performed with and without a beam range shifter, and with different air gaps between the range shifter and a solid water phantom. The absorbed dose, the dose-mean lineal energy, and the dose equivalent were determined for different detector positions using the variance–covariance method. The influence from beam energy, detector- and range-shifter positions on absorbed dose, LET, and dose equivalent were investigated. Monte Carlo simulations of the fluence, detector response, and absorbed dose contribution from different particles were performed with MCNP 6.2. The simulated dose response for protons, neutrons, and photons were compared with, and showed good agreement with, previously published experimental data. The simulations also showed that the TEPC absorbed dose agrees well with the ambient absorbed dose for neutron energies above 20 MeV. The results illustrate that changes in both dose and LET variations in the stray radiation field can be identified from TEPC measurements using the variance–covariance method. The results are in line with the changes seen in the simulated relative dose contributions from different particles associated with different proton energies and range-shifter settings. It is shown that the proton contribution scattered directly from the range shifter dominates in some situations, and although the LET of the radiation is decreased, the ambient dose equivalent is increased up to a factor of 3.

Abstract Ionizing radiation at aircraft and commercial suborbital spaceflight altitudes is driven by space weather and is a health concern for crew and passengers. We compare the response functions of two radiation detectors that were exposed to four different ground‐based laboratory radiation fields as well as flown alongside each other on aircraft. The detectors were a tissue equivalent proportional counter (TEPC) and a Teledyne silicon micro dosimeter chip that was integrated into an Automated Radiation Measurements for Aerospace Safety Flight Module (ARMAS FM). Both detectors were flown onboard commercial and research aircraft. In addition, both detectors were exposed neutrons at the Los Alamos Neutron Science Center, protons at Loma Linda University Medical Center, 56Fe particles at the NASA Space Radiation Laboratory, and also a gamma radiation source at Lawrence Livermore National Laboratory. The response of each of these instruments as well as derived dosimetric quantities are compared for each radiation exposure and the ratio for converting ARMAS absorbed dose in silicon to an estimated absorbed dose in tissue is obtained. This process resulted in the first definitive calibration of the silicon‐based detector like ARMAS to TEPC. In particular, with seven flights of both instruments together, the ARMAS‐derived dose in tissue was then validated with the TEPC‐measured dose in tissue and these results are reported. This work provides a method for significantly improving the accuracy of radiation measurements relevant to human tissue safety using a silicon detector that is easy to deploy and can report data in real time.