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Information about the find of Primula macrocalyx Bunge in the Tyumen Province is given. On the territory of the province this species was first found by P.N. Krylov in 1937. Since then, no new discoveries have been made, and the primrose was considered an extinct species. In May 2017 the growth of this species was discovered by us in the Zavodoukovskiy district. This is one of the northernmost locations of P. macrocalyx in Western Siberia. A large population has at least a thousand clones on an area of about 4 hectares. Recommendations are given for the inclusion of the P. macrocalyx in the list of species to be included in the Red Book of the Tyumen Province.

A sociological monitoring of patients with arterial hypertension. (211 elderly, 107 senile and 108 patients of working (middle) age) with the specially developed original questionnaire was conducted. Among elderly and senile patients a large number of widowed and living alone were detected. Patients of elder age groups are less likely to pay for treatment; most patients believe that health care should only be free. Medical-social indicators in patients with arterial hypertension age groups may worsen the course and prognosis of the disease.

Впервые для территории Западной Сибири приводятся данные о находке Utricularia macrorhiza (Lentibulariaceae) в окрестностях г. Нефтеюганска.

In severe concomitant injury, there is evidently activated formation of free radicals with a further increase in the rate of lipid per-oxidation and with simultaneous depletion of antioxidant system activity. The administration of the traditional doses of antioxi-dants is ineffective. Higher-dose antioxidant therapy and use of novel agents can cause a considerable reduction in the rate of free radical processes and improve the results of treatment. Key words: oxidative stress, lipid peroxidation, antioxidants, lactoferrin.

Objective: to define the degree of activation of lipid peroxidation in patients with severe concomitant injury and to determine whether they could be corrected with the antioxidant agent Laprot. Subjects and methods. The time course of changes in lipid peroxidation parameters and clinical data was studied in 68 patients with severe concomitant injury, in 35 of whom Laprot (made by P. A. Herzen Moscow Oncological Research Institute, Russian Agency for Medical Technologies (Russia), was added to the standard treatment. Results. The significant activation of oxidative processes and lipid peroxi-dation, which was accompanied by antioxidant system imbalance, was ascertained to occur in severe concomitant injury. Key words: injury, lipid peroxidation, lactoferrin.