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1. Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin

Author

Nga Chu Lui, Wing Yip Tam, Caiji Gao, Jian-Dong Huang, Chi Chiu Wang, Liwen Jiang, Wing Ho Yung, and Kin Ming Kwan

Subjects
Science
Abstract

Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and dysregulation of this process leads to ataxia and other diseases. Here the authors show that the LIM-homeodomain transcription factors Lhx1 and Lhx5 govern dendritogenesis and dendritic spine morphogenesis in postnatal PCs through regulating Espin expression.

Published
2017
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