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1. AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis

Author

Xiaoyu Tracy Cai, Hongjie Li, Abu Safyan, Jennifer Gawlik, George Pyrowolakis, and Heinrich Jasper

Subjects
Science
Abstract

Regeneration after injury in the Drosophila intestine involves early activation of intestinal stem cells (ISCs) and subsequent return to quiescence. Here the authors show that return to quiescence by ISCs involves BMP Type I receptor Tkv protein stabilization along with AWD mediated internalization into endocytic vesicles.

Published
2019
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