Search

Background International Mission on Prognosis and Analysis of Clinical Trial (IMPACT) and Corticosteroid Randomisation after Significant Head Injury (CRASH) are internationally influential prognostic models for traumatic brain injury (TBI), which need to be continuously developed, improved and continuously verified externally to ensure generalizability to different settings. Objective To verify and compare the prognostic evaluation values of IMPACT and CRASH simultaneously in TBI population in China. Methods A total of 210 TBI patients treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from 2017 to 2019 were retrospectively selected as the study objects, and the basic information of the included patients was collected. The 14-day survival and 6-month Glasgow prognostic score (GOS) of the patients were followed up until June 2021, with a termination event of loss of follow-up. Receiver operating characteristic (ROC) curve was plotted to evaluate the predictive efficacy of IMPACT and CRASH models in TBI patients, and the area under ROC curve (AUC) was calculated. Brier score was used to evaluate the calibration degree of the model. Results The average age of the patients was (54.0±17.4) years. The ROC curves of the IMPACT model and CRASH model to predict the prognosis of TBI patients were plotted, respectively, and the results showed that the AUCs of IMPACT core model, CT model and laboratory model to predict the poor prognosis of GOS in TBI patients at 6 months was 0.807 (95%CI=0.747-0.866, P

Both the International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) and the Corticosteroid randomization after significant head injury (CRASH) models are globally acknowledged prognostic algorithms for assessing traumatic brain injury (TBI) outcomes. The aim of this study is to externalize the validation process and juxtapose the prognostic accuracy of the CRASH and IMPACT models in moderate-to-severe TBI patients in the Chinese population.

Aiming at the problem of delayed repair of cracks in the airtight wall of the goaf, a method to initiate crack repair using microcapsules in the initial stage of crack evolution of the airtight wall (cracking period) is proposed. This method makes use of the stress at the crack tip. The microcapsule wall is torn to allow the repair agent wrapped in the wall of the capsule to flow out and fill the gap. After the curing reaction, crack repair is completed. During the crack repair process of the airtight wall, the particle size of the microcapsule affects the strength of the capsule wall and directly affects the repair effect. In order to study the influence of particle size on the strength of microcapsules, eight kinds of microcapsules with different particle diameters and the same wall thickness were prepared by orthogonal experiments. The particle size and wall thickness were characterized by SEM, and the strength of the capsule wall was measured using nanoindentation technology. The quadratic function relationship that the strength of the capsule wall decreases with the increase of the particle size is obtained.