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Background: The purpose of this analysis was to investigate the associations between phase angle (PhA), body mass index (BMI) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM). Methods: The retrospective cross-sectional study included 200 T2DM patients treated during 2018 to 2019 in Zhongda Hospital Southeast University. PhA and other body composition indicators were measured by bioelectrical impedance analysis (BIA). Subjects were classified into four groups based on body composition: low phase angle and low body mass index (LPLB), low phase angle and high body mass index (LPHB), high phase angle and low body mass index (HPLB) and high phase angle and high body mass index (HPHB). Results: Overall, in the unadjusted model and minor, all adjusted models (unadjusted model, models 1–4), homeostasis model assessment of insulin resistance (HOMA-IR) was higher in the LPHB group than in the LPLB group (P = 0.034). In the unadjusted model, Model 1 (adjustment for age), Model 2 (adjust for age+duration), Model 3 (adjust for age+duration+sex+UA+TG+TC) and Model 4 (adjust for age+duration+sex+UA+TG+TC+HDL+HbA1c), the adjusted ORs for participants were 4.4 (95% CI [1.72–11.24]), 4.41 (95% CI [1.73–11.27]), 4.75 (95% CI [1.83–12.32]), 2.93 (95% CI [1.04–8.23]) and 3.1 (95% CI [1.09–8.86]) respectively, compared to LPHB group. Conclusions: T2DM patients with the body composition of low phase angle and high body mass index exhibited the most severe degree and the highest risk of insulin resistance.

Abstract Consecutive uranium extraction from seawater is a promising approach to secure the long-term supply of uranium and the sustainability of nuclear energy. Here, we report an ultra-highly efficient strategy via studtite nanodots growth with impressive uranyl uptake capacity of ~ 154.50 mg/g from natural seawater in 12 consecutive days (i.e., average for ~ 12.875 mg/g/day). Uranyl can be extracted as studtite under visible light via the reaction between the adsorbed uranyl and the photogenerated H2O2 with imine-based Covalent-Organic Framework photocatalysts. In detail, over Tp-Bpy, Tp-Bpy-2 and Tp-Py with multiple uranyl chelating sites, uranyl is found extracted as studtite nanodots which can be eluted readily, while over Tp-Bd and Tb-Bpy, uranyl is transformed into studtite nanorods that is more inert for elution. Abundant chelating sites of uranyl via structural regulation of COF photocatalysts are proved to facilitate the formation and efficient elution of studtite nanodots.

BackgroundThe purpose of this analysis was to investigate the associations between serum uric acid and phase angle in patients with type 2 diabetes mellitus.MethodsIn this retrospective cross-sectional study, we included 200 type 2 diabetes mellitus (T2DM) patients treated during 2018–2019 at Zhongda Hospital Southeast University. Phase angle (PhA) and other body composition indicators were measured by bioelectrical impedance analysis (BIA). All patients underwent routine clinical examinations on the day of hospitalization, and the basic information and clinical symptoms of these patients were recorded.ResultsSerum uric acid (UA) was significantly associated with PhA (p

Background Sarcopenia is prevalent and is associated with the occurrence of cardiovascular complications in patients undergoing maintenance hemodialysis (MHD). It is unknown how skeletal muscle may be associated with aspects of myocardial structure and function. This study aimed to evaluate the association between sarcopenia and cardiac structure and function in patients undergoing MHD. We also examined the prognostic role of sarcopenia for mortality and cardiovascular events (CVE) in this population. Methods Participants from a single center underwent bioimpedance body composition analysis to measure skeletal muscle and echocardiography to assess myocardial structure and function. Sarcopenia was diagnosed based on the Asian Working Group for Sarcopenia criteria. The end points were all-cause mortality and CVE. Results Of the 158 participants, 46 (29.1%) had sarcopenia, 102 (64.6%) had left ventricular diastolic dysfunction (LVDD), and 106 (67.0%) had left ventricular hypertrophy (LVH). Participants with sarcopenia had smaller right ventricular sizes (2.54 ± 0.77 vs 2.76 ± 0.28; P < 0.01), inter-ventricular thickness (1.07 ± 0.19 vs 1.14 ± 0.20; P = 0.039), and left ventricular posterior wall thickness (0.96, 0.89–1.10 vs 1.06, 0.95–1.20; P = 0.018). Skeletal muscle mass was strongly correlated with left ventricular mass (LVM) (r = 0.577; P < 0.0001). Furthermore, the risk of LVDD (OR: 4.92, 95% confidence interval (CI) [1.73–13.95]) and LVH (OR: 4.88, 95% CI [1.08–21.96]) was much higher in the sarcopenic group than in the non-sarcopenic group. During a follow-up period of 18 months, 11 (6.9%) patients died, of which seven died (4.4%) of CVE, and 36 (22.8%) experienced CVE. The presence of sarcopenia (adjusted hazard ratio (HR), 6.59; 95% CI [1.08–39.91]; P = 0.041) and low skeletal muscle index (HR, 3.41; 95% CI [1.01–11.57]; P = 0.049) and handgrip strength (HR, 0.88; 95% CI [0.78–0.99]; P = 0.037) independently predicted death. Sarcopenia was a significant predictor of CVE (HR, 10.96; 95% CI [1.14–105.10]; P = 0.038). Conclusion Our findings demonstrated that sarcopenia is associated with LVDD and LVH, and is associated with a higher probability of death and CVE.

Congenital thrombotic thrombocytopenic purpura (cTTP) is a thrombotic microangiopathy (TMA) characterized by severe hereditary ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs 13) deficiency caused by ADAMTS13 mutations. This rare autosomal recessive genetic disorder is often misdiagnosed as immune thrombocytopenia (ITP) or hemolytic uremic syndrome (HUS). Here, we report a 21-year-old male cTTP patient with a compound heterozygous ADAMTS13 mutation. The patient was admitted for acute thrombocytopenia, with a 5-year history of chronic thrombocytopenia and 1 month of renal dysfunction. Initially diagnosed with ITP, he was treated with immunosuppressive therapy, including glucocorticoids and intravenous immunoglobulin, which provided temporary relief but failed to prevent recurrent thrombocytopenia. Ultimately, cTTP was confirmed by the low ADAMTS13 0% activity and two heterozygous variants (c.1335del and c.1045C > T) in the ADAMTS13 gene, and the patient received prophylactic fresh-frozen plasma (FFP) infusions every 2–3 weeks regularly. Interestingly, the patient also exhibited elevated sC5b-9 levels during the acute phase, necessitating differentiation from HUS. This report highlights a cTTP caused by a compound heterozygous ADAMTS13 mutation, although its pathogenesis requires further investigation. Given the atypical clinical manifestations of cTTP, it is necessary to conduct ADAMTS13 activity and even genetic testing in patients with recurrent thrombocytopenia and end-organ damage.

The evolution towards centralized radio access network (C-RAN) for 5G is driven by the need for improved network performance and reduced total-cost-of-ownership (TCO). In C-RAN, physically separated remote radio units (RRUs) and baseband units (BBUs) are connected via fronthaul (FH) links, which are capacity constrained. When base-station antennas are upgraded to support massive MIMO techniques, an intra PHY split between RRU and BBU becomes favorable to avoid the dramatic rate growth on the FH links. In this paper, we present a new uplink functional split alternative that decomposes the massive MIMO processing, on the basis of zero-forcing (ZF) equalization, into two phases: dimensionreduction phase and interference cancellation phase, which are implemented in RRU and BBU respectively. Compared with the traditional C-RAN architecture having all baseband processing in the BBU, the new scheme largely alleviates the FH load by reducing the number of FH streams to be equal to the number of MIMO user layers. Compared with an existing split that places all MIMO processing in RRU, the new scheme reduces the RRU complexity without compromising the post-processing performances.