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ABSTRACT Presacral neuroendocrine tumor (PSNET) is a rare disease that currently lacks a standardized treatment approach. In this report, we present a unique case of PSNET with liver metastasis that progressed into a pseudosacral cyst following complete surgical resection and sulfatinib treatment with radiofrequency ablation. Before undergoing surgical treatment for presacral neuroendocrinology, it is important to consider the potential risks of poor healing of the presacral incision and formation of pseudocysts. These complications may be caused by various factors, including the procedure itself and the use of targeted drugs.

In this paper， the data quality control of the flood season precipitation and extreme precipitation of the regional meteorological stations and national meteorological stations in Gansu Province from 2011 to 2020 has been carried out， and 1253 regional meteorological stations and 75 national meteorological stations have been selected to analysis the precipitation characteristics.The results show that the average precipitation amount of the regional meteorological stations in Gansu Province is very close to that of the national meteorological stations， and there is no significant difference.The average precipitation of the regional meteorological stations in flood season in Gansu province is 382.9 mm， and that of the national meteorological stations is 379.7 mm.The average monthly precipitation of regional meteorological stations distributes from 31.7 mm to 87.1 mm， and that of national meteorological stations distributes from 30.4 mm to 86.4 mm.However， there are significant differences in the extremes of precipitation between the two types of meteorological stations.The maximum of total precipitation at regional meteorological stations in flood season even reaches 917.5 mm， the maximum monthly precipitation reaches 776 mm， and the maximum number of rainstorm days reaches 46 d·（10a）-1.However， those of national meteorological stations is 710.7 mm， 541 mm and 17 d·（10a）-1， respectively.The spatial locations of precipitation maxima of regional meteorological stations and national meteorological stations are close to each other， but the numerical values of regional stations are significantly higher than those of national stations.The spatial trends of precipitation at the two stations are very consistent， and the correlation coefficient of flood season precipitation of two types stations is 0.95， the correlation coefficient of monthly extreme precipitation is 0.92.Moreover， regional meteorological stations show many higher and less value centers of small patches than national stations； the spatial precipitation difference between the two types of meteorological stations are clearly in the east and south of Gansu Province.Overall， the regional meteorological stations describe the precipitation characteristics of Gansu Province in a more detailed way.More extreme precipitation events are monitored in those regions with complex terrain， and the extreme value of precipitation is larger than that of national meteorological stations.The rainstorm and flood disaster prevention in these regions should be based on the data of regional meteorological stations to enhance the disaster risk prevention ability.

As an environmentally friendly material, biochar is increasingly being utilized in the field of heat transfer and thermal conduction. In this study, nano-biochar was prepared from high-pressure homogenization (HPH) using sesame stalks as the raw material. It was incorporated into ethylene glycol (EG) and its dispersion stability, viscosity, and thermal conductivity were investigated. The nano-biochar was stably dispersed in EG for 28 days. When the concentration of the nano-biochar added to EG was less than 1%, the impact on viscosity was negligible. The addition of 5 wt.% nano-biochar to EG improved the thermal conductivity by 6.72%, which could be attributed to the graphitized structure and Brownian motion of the nano-biochar. Overall, nano-biochar has the potential to be applied in automotive thermal management.

Myocardial remodeling refers to structural and functional disorders of the heart caused by molecular biological changes in the cardiac myocytes in response to neurological and humoral factors. A variety of heart diseases, such as hypertension, coronary artery disease, arrhythmia, and valvular heart disease, can cause myocardial remodeling and eventually lead to heart failure. Therefore, counteracting myocardial remodeling is essential for the prevention and treatment of heart failure. Sirt1 is a nicotinamide adenine dinucleotide+-dependent deacetylase that plays a wide range of roles in transcriptional regulation, energy metabolism regulation, cell survival, DNA repair, inflammation, and circadian regulation. It positively or negatively regulates myocardial remodeling by participating in oxidative stress, apoptosis, autophagy, inflammation, and other processes. Taking into account the close relationship between myocardial remodeling and heart failure and the involvement of SIRT1 in the development of the former, the role of SIRT1 in the prevention of heart failure via inhibition of myocardial remodeling has received considerable attention. Recently, multiple studies have been conducted to provide a better understanding of how SIRT1 regulates these phenomena. This review presents the progress of research involving SIRT1 pathway involvement in the pathophysiological mechanisms of myocardial remodeling and heart failure.

Coronary atherosclerotic heart disease, cerebrovascular disease, and peripheral artery disease are common diseases with high morbidity and mortality rates and must be addressed. Their most frequent complications, including myocardial infarction and stroke, are caused by spontaneous thrombotic occlusion and are the most frequent cause of death worldwide. Atherosclerosis (AS) is the most widespread underlying pathological change for the above diseases. Therefore, drugs that interfere with this pathophysiological process must be incorporated in the treatment. Chinese traditional and herbal drugs can effectively treat AS. With the development of traditional Chinese medicine, the active ingredients in common Chinese medicinal materials must be thoroughly purified prior to their application in western medicine. Various proprietary Chinese medicine preparations with remarkable effects have been used in AS treatment. Catalpol, the active component of Rehmannia glutinosa, belongs to iridoid terpene and has anti-inflammatory, antioxidant, insulin resistance improvement, and other related effects. Several reviews have been conducted on this compound and its actions against osteoporosis, neurodegenerative diseases, Alzheimer's disease (AD), Parkinson's disease (PD) and diabetes and its complications. The current review focused on catalpol’s effect on atherosclerotic plaque formation in different animal models. The potential mechanisms of catalpol to ameliorate AS were also summarized in terms of oxidative stress, inflammation, cell aging, apoptosis, and activation of the silent information regulator factor 2-related enzyme 1 (SIRT1) pathway.

During the second half of the 20th century, eastern Northwest China experienced a warming and drying climate change. To determine whether this trend has continued or changed during the present century, this study systematically analyzes the characteristics of warming and dry–wet changes in eastern Northwest China based on the latest observational data and World Climate Research Programme (WCRP) Coupled Model Intercomparison Project Phase 6 (CMIP6) collection data. The results show that eastern Northwest China has warmed continuously during the past 60 years with a sudden temperature change occurring in the late 1990s. However, the temperature in the 2000s decreased slowly, and that in the 2010s showed a warming trend. The amount of precipitation began to increase in the late 1990s, which indicates a contemporary climate transition from warm-dry to warm-wet in eastern Northwest China. The contribution of precipitation to humidity is significantly more than that of temperature. Long-term and interannual variations dominate the temperature change, with the contribution of the former much stronger than that of the latter. However, interannual variation dominates the precipitation change. The warming accelerates from period to period, and the temperature spatial consistently increased during the three most recent climatic periods. The precipitation decreased from 1961–1990 to 1981–2010, whereas its spatial consistency increased from 1981–2010 to 1991–2019. The significant warming and humidification which began in the late 1990s and is expected to continue until the end of the 21st century in the medium emission scenario. However, the current sub-humid climate will not easily be changed. The warming could cause a climate transition from warm temperate to subtropical by 2040. The dry-to-wet climate transition in eastern Northwest China could be related to a synergistic enhancement of the East Asian summer monsoon and the westerly circulation. This research provides a scientific decision-making basis for implementing western development strategies, ecological protection, and high-quality development of the Yellow River Basin Area as well as that for ecological construction planning and water resource management of eastern Northwest China.