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Background and Objectives: Patients with multiple sclerosis, especially those treated with immunosuppressive drugs, are less immune than normal individuals and may be more susceptible to Covid 19. The aim of this study was to determine the level of knowledge of patients with MS of Covid 19 during the corona epidemic in Jahrom in 2021. Methods: This descriptive cross-sectional census study was performed on 191 patients with definite multiple sclerosis in Jahrom in 2021. Data collection tools included a demographic information questionnaire and a standard questionnaire for MS patients’ knowledge of Covid 19. Questionnaire information was collected in SPSS software version 21 and collected using descriptive and inferential statistical indicators. Results: Of 191 patients with MS during coron pandemic, 6.3% of them had coronary artery disease. The mean score of MS patients was (80.7%). There was a significant relationship between demographic variables such as gender, education and number of households with patients’ knowledge (P

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also lead to neurological complications. Among COVID-19 patients, the endothelium is considered the Achilles heel. A variety of endothelial dysfunctions may result from SARS-CoV-2 infection and subsequent endotheliitis, such as altered vascular tone, oxidative stress, and cytokine storms. The cerebral hemodynamic impairment that is caused is associated with a higher probability of severe disease and poor outcomes in patients with COVID-19. This review summarizes the most relevant literature on the role of vasomotor reactivity (VMR) in COVID-19 patients. An overview of the research articles is presented. Most of the studies have supported the hypothesis that endothelial dysfunction and cerebral VMR impairment occur in COVID-19 patients. Researchers believe these alterations may be due to direct viral invasion of the brain or indirect effects, such as inflammation and cytokines. Recently, researchers have concluded that viruses such as the Human Herpes Virus 8 and the Hantavirus predominantly affect endothelial cells and, therefore, affect cerebral hemodynamics. Especially in COVID-19 patients, impaired VMR is associated with a higher risk of severe disease and poor outcomes. Using VMR, one can gain valuable insight into a patient’s disease progression and make more informed decisions regarding appropriate treatment options. A new pandemic may develop with the COVID-19 virus or other viruses, making it essential that healthcare providers and researchers remain focused on developing new strategies for improving survival in such patients, particularly those with cerebrovascular risk factors.