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Abstract Type 2 Diabetes Mellitus (T2DM) is a significant public health problem globally. The diagnosis and management of diabetes are critical to reduce the diabetes complications including cardiovascular disease and cancer. This study was designed to assess the potential association between T2DM and routinely measured hematological parameters. This study was a subsample of 9000 adults aged 35–65 years recruited as part of Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study. Machine learning techniques including logistic regression (LR), decision tree (DT) and bootstrap forest (BF) algorithms were applied to analyze data. All data analyses were performed using SPSS version 22 and SAS JMP Pro version 13 at a significant level of 0.05. Based on the performance indices, the BF model gave high accuracy, precision, specificity, and AUC. Previous studies suggested the positive relationship of triglyceride-glucose (TyG) index with T2DM, so we considered the association of TyG index with hematological factors. We found this association was aligned with their results regarding T2DM, except MCHC. The most effective factors in the BF model were age and WBC (white blood cell). The BF model represented a better performance to predict T2DM. Our model provides valuable information to predict T2DM like age and WBC.

Objective: Patellofemoral Pain Syndrome (PFPS) is one of the most common disorders of the knee joint. It is characterized by pain, reduced proprioception, and altered pattern of vastus muscle activation, which effectively maintain the balance needed for performing daily living activities such as walking and running. One treatment method that can reduce pain and improve balance in people with PFPS is Kinesiology Taping (KT). Considering the physiological and anatomical differences in the knee structure of men and women and the importance of studying the effect of KT on the dynamic balance of men with PFPS, this study aims to compare the effect of KT on dynamic balance and pain of men and women with unilateral PFPS. Materials & Methods: This is a quasi-experimental and non-randomized clinical trial. The participants were 30 males and 31 females aged 18-40 years suffering from unilateral PFPS. They were recruited using a convenience sampling method. First, the subjects performed the Y-balance test three times in each of the anterior, posteromedial, and posterolateral directions. The maximum score obtained from the three repetitions in each direction was divided by the limb length and recorded in percentage as a dynamic balance score. After 5 minutes of rest and performing initial tests, the subjects performed the intervention. In this stage, KT with a tension equal to 50%-75% of its initial length was applied on the patella of the involved limb to cause medial glide. The effectiveness of KT was examined under a single-leg squat-test. For this purpose, all subjects performed unilateral squatting on their affected leg for 10 seconds with 45 degrees of knee flexion before and after KT, while their pain level was recorded using the visual analog scale. In case of a 50% reduction in pain, the subjects were allowed to enter the final stage (performing the Y-balance test); otherwise, patellar taping was repeated to obtain the appropriate pain reduction. Results: Within-group comparison of balance parameters before and after KT using the paired t-test showed an increase in the reach distance at three directions in the Y-balance test, revealing a significant improvement in the dynamic balance following KT (P0.05). Moreover, the pain was significantly reduced in both genders after KT (P0.05). Conclusion: KT is an appropriate therapeutic intervention for improving dynamic balance and reducing pain in people with PFPS. It seems that KT has the same effect on dynamic balance and pain of women and men with PFPS.