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Abstract Background The human placenta is critical in supporting fetal development, and placental dysfunction may compromise maternal-fetal health. Early detection of placental dysfunction remains challenging due to the lack of reliable biomarkers. This study compares placental quantitative susceptibility mapping and T2* values between healthy and high-risk pregnancies and investigates their association with maternal and fetal parameters and their ability to predict birth weight (BW). Methods A total of 105 pregnant individuals were included: 68 healthy controls and 37 high-risk due to fetal growth restriction (FGR), chronic or gestational hypertension, and pre-eclampsia. Placental magnetic resonance imaging data were collected using a three-dimensional multi-echo radiofrequency-spoiled gradient-echo, and mean susceptibility and T2* values were calculated. To analyze associations and estimate BW, we employed linear regression and regression forest models. Results No significant differences were found in susceptibility between high-risk pregnancies and controls (p = 0.928). T2* values were significantly lower in high-risk pregnancies (p = 0.013), particularly in pre-eclampsia and FGR, emerging as a predictor of BW. The regression forest model showed placental T2* as a promising mode for BW estimation. Conclusion Our findings underscore the potential of mean placental T2* as a more sensitive marker for detecting placental dysfunction in high-risk pregnancies than mean placental susceptibility. Moreover, the high-risk status emerged as a significant predictor of BW. These results call for further research with larger and more diverse populations to validate these findings and enhance prediction models for improved pregnancy management. Relevance statement This study highlights the potential of placental T2* magnetic resonance imaging measurements as reliable indicators for detecting placental dysfunction in high-risk pregnancies, aiding in improved prenatal care and birth weight prediction. Key Points Placental dysfunction in high-risk pregnancies is evaluated using MRI T2* values. Lower T2* values significantly correlate with pre-eclampsia and fetal growth restriction. T2* MRI may predict birth weight, enhancing prenatal care outcomes. Graphical Abstract

Abstract Intrauterine fetal programming determines cardiorenal interaction later in life. We hypothesize that early life factors affect adult glomerular filtration rate and mean arterial pressure (MAP) directly or by interacting with postnatal growth trajectories. The population-based LifeGene study (Sweden) randomly recruited individuals aged 18 to 43 years (n = 12 167). They filled in a web-questionnaire and performed health tests (including bioimpedance measurements). Birth weight (BW), gestational age (GA), head circumference (HC), and birth length data were acquired from the Swedish Medical Birth Register. Postnatal growth was determined from BWz-scores and adult fat mass index. Creatinine and cystatin C-based kidney function were calculated (eGFRcr, eGFRcysC). After adjusting for sex, GA, adult age, and eGFRcr, a 1SD increase in BWz-score predicted a 1.15 mmHg increase in MAP. Meanwhile, every 1 cm decrease in HC was associated with an expected 0.29 mL/min/1.73m2 decrease in eGFRcr. Lower birth weight-to-placenta ratio was inversely related to eGFRcysC (p = 0.034). Postnatal down-regulation significantly affected a relatively lower eGFR but within normal range (p

Abstract Background Macrosomia presents significant risks to both maternal and neonatal health, however, accurate antenatal prediction remains a major challenge. This study aimed to develop machine learning approaches to enhance the prediction of fetal macrosomia at different stages of pregnancy. Methods This retrospective study involved 500 pregnant women who delivered singleton infants at Beijing Tsinghua Changgung Hospital between December 2019 and July 2024. The training set comprised 208 cases of macrosomia and 208 non-macrosomia cases, with 84 additional cases used for external validation. A total of 23 candidate variables, including maternal characteristics, physical measurements, and laboratory tests were collected for feature selection. Seven algorithms were applied in combination with three sets of selected features, resulting in 21 fitted models. Model performance was evaluated via the area under the receiver operating characteristic curve (AUC), accuracy, precision, sensitivity, specificity, and F1-score. Results Maternal height, pre-pregnancy weight, first-trimester weight, pre-labor weight, gestational age at birth, gestational weight gain, and the proportion of male neonates were significantly greater in the macrosomia group compared to non-macrosomia group in the training set (p

Abstract Background Air pollution exposure during pregnancy has been associated with adverse birth outcomes. Uncertainties remain about the effect at very low exposure levels. The aim of this study was to explore the association of maternal exposure to air pollutants during pregnancy at very low exposure levels with birth weight and estimate the health impact. Methods The MATEX birth cohort (226,551 singleton births in 2012–2016) was linked with eight modelled air pollutants (PM2.5, PM10, PMcoarse, NO2, NOx, CO, SO2, O3) at home address during pregnancy. Multiple regression was used to estimate the change in birth weight (in g) associated with individual-level mean exposure during pregnancy. We tested different adjustment models and conducted sensitivity analyses. We also estimated the potential number of low birth weight cases attributable to PM2.5 to quantify the public health issues at the prevailing low exposure levels. Results PM2.5 was associated with the largest reduction of birth weight (-6.5 g per 1 µg/m3) followed by PMcrs (-4.9 g) and PM10 (-3.0 g). Among the gaseous pollutants the strongest reduction in birth weight was observed for NO2 (-0.8 g), followed by CO (-0.5 g), NOx (-0.4 g) and SO2 (-0.2 g). On the contrary, O3 was associated with a modest increase in birth weight (+ 0.9 g). Effects on births weight were observed also below WHO guideline values. When accounting for the prevailing exposure levels in Finland, CO was associated with the biggest reduction in birth weight. The effect of PM2.5 exposure on birthweight corresponds to a loss of 30 g at mean exposure. Assuming a causal relationship, about 700 cases of low birth weight could be attributable to PM2.5 in Finland during the study period. Conclusions No clear evidence on safe exposure level was found in this study. All pollutants were associated with reduced birthweight except ozone. Causality and confounding due to correlations warrant specific attention.

Objective This study aimed to develop genomic and phenotypic indices for beef cattle selection that afford progeny with reduced birth weight and fattening period. The indices should also allow regulating total weight gain during the fattening period and avoid marked increases of inbreeding. Methods Whether addition of constraint on total weight gain to constraints on body weight gain at up to four specific time points during the fattening process was effective for the weight gain until the end of the fattening period was examined in two selection indices with the selection trait being a phenotypic or a genomic breeding value random regression coefficient. Results Both indices afforded cattle with desired weight gains at specific time points and desired total weight gains. One cycle of index-based selection made it possible to shorten the fattening period two weeks compared with that before selection while maintaining the same final fattening weight as before selection. The impact of constraining total weight gain was smallest when the number of weight gain constraints at specific time points was three or four. However, constraining total weight gain was necessary to avoid poor total weight gain when the number of weight gain constraints at specific time points was only one or two. Conclusion The developed indices make it possible to regulate total weight gain during the fattening process and to achieve desired weight gains at specific time points. Importantly, the indices bring about genetic improvement without an excessive increase of inbreeding. Thus, we expect that these indices will contribute to sustainable genetic improvement in cattle while maintaining genetic diversity.

Purpose: The study was aimed to elucidate the incidence and associated risk factors for Retinopathy of Prematurity (ROP) in new-born babies in a tertiary care teaching hospital in North India. Methods: The present study was a prospective follow-up study involved in the screening of new-born babies who are at risk of developing ROP conducted in the Ophthalmology department of a teaching hospital in Jammu district, India. Results: During the course of the present study, 199 infants were screened and 13 were found to be having ROP. Incidence of ROP thus was 6.53%. Univariate analysis revealed that neonatal factors like birth weight, O2 supplementation >5 days, patent ductus arterious, sepsis and apnoea of prematurity were significantly associated with ROP (P < 0.05). C-PAP and mechanical ventilation (>5 days) were the only significant predictors for ROP on multivariate logistic regression. Conclusion: A relatively low incidence of ROP was observed with neonatal risk factors more significantly associated with ROP. The prevention of pre-term births and sustaining the gains in neonatal care should go a long way to reduce the incidence of ROP in infants.

A hybrid camel Tülü (Bactrian male x Dromedary female F1) males are preferred in camel wrestling, which is a culture unique to Anatolia. In this study, changes of live weight (LW), daily weight gain (DWG), and body measurements (BMs) of Tülü calves in the first 6 months of age in a farm in Aydın province, Türkiye, were determined as well as developing equations to estimate LW from body measurements. Tülü calves average birth weight (BW) was 34.7±1.80 kg and reached 175.3±3.38 kg at the age of 6 months with a 0.768±0.03 kg DWG during this time. Although the monthly total weight gains and monthly DWG averages of the calves in the first 6 months were similar, the changes in monthly LW and BMs were statistically significant (P

Abstract Background Ramadan during pregnancy is associated with adverse offspring health outcomes. Recent evidence from Europe indicates that maternal diet during non-fasting hours might alleviate these effects. This study describes fasting, diet, and sleep habits among pregnant Muslims in Kaduna, Nigeria, and assesses impacts on neonatal health in this setting. Methods Between July 2023 and February 2024, we conducted 1814 interviews with women whose pregnancy overlapped with Ramadan 2023 in Kaduna, northwestern Nigeria (cross-sectional study). We used a structured questionnaire to collect data on fasting, diet and sleep during Ramadan, as well as maternal socio-demographic characteristics. In the analyses of birth outcomes, 1370 mother-newborn pairs were included. We performed multivariate regression analyses to evaluate associations between fasting and birth weight and gestational duration, as well as the interaction of fasting with maternal dietary intake and sleep patterns. Results More than 80% of the study participants fasted during pregnancy. Women who fasted had infants with lower birth weights than non-fasting participants (-90.38 g, 95% CI: -173.64 g to -6.12 g). No independent associations were detected between reduced sleep and food intake, and birth weight. Fasting was not associated with gestational duration. Negative effects of fasting on birth weight were consistently concentrated among participants who reduced their dietary or fluid intake during Ramadan. Conclusions Dietary intake during non-fasting hours might mitigate potential adverse effects of Ramadan fasting on birth weight. With more than 25% of the global population adhering to Islam, this study highlights the need for additional research on Ramadan during pregnancy across different settings.

Achim Fieß,1,&ast; Sandra Gißler,1,&ast; Stephanie Grabitz,1 Philipp S Wild,2– 5 Karl J Lackner,6 Manfred E Beutel,7 Michael S Urschitz,8 Oliver Tüscher,5,9,10 Thomas Münzel,11 Jörn M Schattenberg,12,13 Stavros V Konstantinides,2,14 Norbert Pfeiffer,1 Alexander K Schuster1 1Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 2Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany; 3German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; 4Preventive Cardiology and Preventive Medicine-Department of Cardiology, University Medical Center Mainz, Mainz, Germany; 5Institute of Molecular Biology (IMB), Mainz, Germany; 6Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; 7Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 8Division of Pediatric Epidemiology, Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 9Clinic for Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; 10Leibniz Institute for Resilience Research, Mainz, Germany; 11Center for Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; 12Department of Internal Medicine II, Saarland University Medical Center, Homburg, Germany; 13Department of Internal Medicine I, University Medical Center, Mainz, Germany; 14Department of Cardiology, Democritus University of Thrace, Alexandroupolis, 68100, Greece&ast;These authors contributed equally to this workCorrespondence: Achim Fieß, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz, 55131, Germany, Tel +49-(0)6131-17-5150, Fax +49-(0)6131-17-8495, Email achim.fiess@gmail.comAbstract: This study investigates the association between self-reported birth weight (BW) and the frequency of cataract and pseudophakia in a large population-based cohort in Germany, as part of the Gutenberg Health Study (GHS). Slit lamp examination and Scheimpflug imaging of 8205 participants, aged 35 to 74, were assessed and signs of cataract or pseudophakia analyzed. The research aimed to explore the correlation between fetal growth restriction and/or prematurity indicated by BW and the frequency of cataract and pseudophakia. In the univariable analysis, cataract was initially associated with low and high BW, but this association disappeared after adjusting for age, sex, examiner and cardiovascular risk factors. No association was found between low BW and pseudophakia or the frequency of cataract surgery within 5 years. The study reveals novel insights from a large population-based study specifically exploring this association.Keywords: Cataract, pseudophakia, birth weight, epidemiology, population-based study

Abstract Background Prevention of iron deficiency in suckling piglets by intramuscular injection of a standardized amount of iron dextran or gleptoferron in the first days of life can lead to over- or underdosage with respective health risks. Currently, combined iron products containing an active substance against coccidia are also used on farms. When using a combination product targeting two diseases, an adjustment of the necessary amount of iron to prevent anaemia in the frame of a farm-specific treatment protocol is not possible. The aim of this study was to test if iron dextran, which can be used in flexible volumes, is statistically non-inferior to a combinatory product, containing gleptoferron and toltrazuril. In addition, different administration schemes for iron dextran with respect to time point and dosage were compared on a conventional farm. Within each out of 17 litters eight healthy piglets were allocated to one of the four treatment groups on the second day of life: (1) 200 mg iron dextran, (2) 200 mg gleptoferron and 45 mg toltrazuril in combination, (3) 300 mg iron dextran, (4) 200 mg iron dextran and additional intramuscular administration of 200 mg iron dextran on day 11 of life. Pigs of groups 1, 3 and 4 received toltrazuril orally. Red blood cell measures were determined prior to treatment on day 2 of life and at weaning. Body weights were measured on day 2, 24, 74 and 160 of life. Results Iron dextran was non-inferior compared to gleptoferron within a tolerance range of ± 5 g haemoglobin/L. In total, treatment groups did not differ with respect to red blood cell parameters and average daily weight gain. The 50% pigs with intermediate birth weights profited from an additional iron dextran administration with respect to higher haemoglobin concentrations at weaning. Conclusions In this investigation gleptoferron and iron dextran appear equally appropriate for prevention of iron deficiency anaemia. Piglets of different birth weights might profit differently from an additional iron administration, so that usage of a product containing iron as a single substance is of advantage to allow a flexible adjustment of dosage during the suckling period.

Abstract This study explored the genetic basis of growth traits in Middle Anatolian Merino lambs using multi-locus genome-wide association study (GWAS) analyses. Descriptive statistics indicated moderate heritability (h² = 0.363) for birth weight (BW) and (h² = 0.309) for weaning weight (WW), both statistically significant (p

Introduction: The placenta helps in supporting the developing fetus by providing essential metabolic, immunological, endocrine, respiratory and nutritional functions. During pregnancy, the placenta grows in size to adequately support the needs of the developing fetus. Abnormalities in placental thickness (PT) can serve as an indicator of potential complications during pregnancy. Utilizing ultrasound technology to assess the thickness of the placenta throughout pregnancy, aiming to identify potential connections with fetal well-being, as well as other relevant factors. In addition, the objective is to establish reference charts for PT during 32 and 36 weeks of gestation. Materials and Methods: An bservational study at a Medical College and Hospital in India, from February 2023–2024, that included 400 patients. The thickness of the placenta was measured at 32 and 36 weeks in women who were referred for antenatal scans. Out of the 400 participants, 25 gave birth before reaching 36 weeks, while the remaining 375 were monitored until they reached 36 weeks. The thickness was categorized into three groups: Normal (10th–90th percentile), thin (90th percentile). The outcomes of the newborns were evaluated after delivery and statistical analysis was conducted using ANOVA to calculate descriptive measures such as the mean and standard deviation. Results: Among the 400 patients at 32 weeks, PT measurements had varied from 25 to 40 mm, with a PT (mean) of approximately 31 mm ± 3.13 mm. At 36 weeks, among the 375 patients, PT ranged from 27 to 44 mm and a mean PT of approximately 35.2 mm ± 3.27 mm. The correlation of PT and the fetal birth weight was noticeable, with a stronger correlation observed at 36 weeks (r = 0.432) compared to 32 weeks (r = 0.316). Conclusion: The overall thickness of the placenta at 32 and 36 weeks is closely related to the stage of pregnancy and can provide valuable insights into the overall wellness of the newborn. It is important to measure PT along with biometric parameters during ultrasound examinations for pregnant women. In addition, we observed the interaction of different factors, including body mass index and parity.

Introduction: Birth weight is vital to an infant’s long-term health and development. This study aims to assess the birth weight of babies born to Saudi women in the Jazan region and to determine the maternal risks influencing it. Materials and Methods: A cross-sectional study covered all the women who delivered babies in three hospitals. Data were gathered from the participants using a semi-structured questionnaire administered during a face-to-face interview, and the birth weight was measured immediately after the baby’s delivery. Results: Of 403 delivered women, 62% were between 21 and 34 years old, with 63% coming from the rural coastal part of the region. About 86% had regular antenatal care visits, ranging between 5 and 9 visits in more than half of the women. Among the participants women, 2.7% were smokers, 4.7% had hypertension, 4.7% had diabetes mellitus, and 27.5% had anemia. Regarding the neonatal outcomes, 55% gave birth to male newborns, and the mode of delivery was normal vaginal in about 69%. The gestational age was a term completing more than 37 weeks in about 92% of women, and the birth weight was 2.961 ± .51; however, 13.4% were low birth-weight newborns (35 years is associated with low birth weight (LBW; odds ratio = 1.86, 95% confidence interval = 1.00–3.46). Conclusion: Although overall birth weight showed normal distribution, the mother’s occupation, smoking, and increased maternal age were all linked to LBW. Therefore, we recommend further studies that include more maternal risk factors.

Abstract Background Maternal nutrition is a key factor influencing birth and offspring health outcomes in later life. Dietary diversity (DD) is a proxy for the macro/micronutrient adequacy of an individual’s diet. There is inadequate comprehensive evidence regarding maternal nutrition during pregnancy, measured through DD and birth outcomes. This study aimed to provide extensive evidence on maternal DD during pregnancy and birth outcomes. Methods A comprehensive search was performed using PubMed, HINARI, and Google Scholar databases up to January 17, 2024. Studies conducted among pregnant mothers and measuring maternal DD with an evaluation of birth outcomes (low birth weight, small for gestational age, preterm birth), in the global context without design restriction were included. The Newcastle Ottawa Scale and the Cochrane Risk of Bias tool were used to assess the risk of bias. The results are summarized in a table, and odds ratios were pooled where possible. Between-study heterogeneity was evaluated using I2 statistics. Potential publication bias was assessed using a funnel plot and Egger’s regression test. To explore the robustness, a leave-one-out sensitivity analysis was conducted. Results Thirty-three studies were used to synthesize narrative evidence (low birth weight: 31, preterm birth: 9, and small for gestational age: 4). In contrast, 24 records for low birth weight, eight for preterm birth, and four for small for gestational age were used to pool the results quantitatively. Of the 31 studies, 17 reported a positive association between maternal DD and infant birth weight, 13 studies reported a neutral association (not statistically significant), and one study reported a negative association. Overall, inadequate DD increased the risk of low birth weight OR = 1.71, 95% CI; (1.24–2.18), with I2 of 68.7%. No significant association was observed between maternal DD and preterm birth. Inadequate DD was significantly associated with small for gestational age (OR = 1.32, 95% CI; 1.15–1.49, and I2 = 0.0%). Conclusion Inadequate maternal DD is associated with an increased risk of low birth weight and small for gestational age but not preterm birth, underscoring the importance of promoting adequate DD during pregnancy. To address these issues, it is essential to implement and expand nutritional programs targeted at pregnant women, especially in low-resource settings, to ensure they receive diverse and adequate diets. Further research is needed to address the current limitations and to explore the long-term implications of maternal nutrition on child health. The study was prospectively registered on PROSPERO (registration number CRD42024513197). No funding was received for this study.

Abstract Background There is still controversy over the association between newborns with different birth characteristics and colorectal cancer (CRC) in adulthood. We plan to use systematic reviews and meta-analysis to elucidate this relationship. Methods Pubmed, Web of Science, EBSCO, and Medline databases were searched for published literature on the impact of birth characteristics on the incidence of CRC until Feb 2024, 1065 articles were included in total and necessary data were extracted for systematic reviews and meta-analysis. Results Ten studies from multiple countries or regions were included. Compared with normal weight, the prevalence of adult CRC in infants with high birth weight (OR = 0.99, 95%CI: 0.92–1.06) and low birth weight (OR = 0.95, 95%CI: 0.89–1.03) did not increase significantly. Infants for every 1 kg increase in birth weight, the incidence of adult CRC increases by 3% (95%CI: -1-8%). For male infants, shorter body length (OR = 1.9, 95%CI: 1.0-3.7) and lighter weight of the placenta (OR = 1.6, 95%CI: 1.0-2.7) indicates that fetal growth restriction is a risk factor for the onset of colorectal cancer. Further epidemiological investigations are needed to verify the association between other birth characteristics and the incidence of colorectal cancer. Conclusion Babies with abnormal birth length, placental weight, and maternal age often suggest growth restriction, which is related to the incidence of adult CRC.

Abstract Background Snuff is a smokeless source of nicotine that is common in Scandinavia and increasingly used by women of fertile age. Persistent use of snuff during pregnancy has been associated with adverse pregnancy outcomes. Emerging data from the Medical Birth Registry of Norway distinguishes between occasional use and daily use. We provide preliminary estimates of associations between frequency of snuff and gestational length and birth weight. Methods Data on snuff use during pregnancies delivered in 2020 and 2021 were available for the west and central regions of Norway. Associations of snuff use with gestational length and birth weight at term (39–41 weeks) were estimated using quantile regression at the 25th, the 50th and the 75th percentiles, with adjustments for mother’s age, pre-pregnancy weight, and parity. We compared associations with the pregnancy outcomes according to maternal snuff and cigarette use. Results 12.4% of 18 042 non-smoking women reported daily use of snuff before pregnancy, and 4.6% reported continuing use during pregnancy, with 1.2% still reporting daily use in the last trimester. Women with daily use through the last trimester delivered babies with a median gestational length reduced by 3.4 days (95% CI: -5.0 to -1.7 days) compared with women who never used snuff. The reduction was even stronger at the 25th percentile of gestational age. The median term birth weight was reduced by 44 g (95% CI: -134 to 46 g). These associations were much weaker for women who quit snuff at some point during pregnancy or used snuff only occasionally. Mothers who smoked daily through the last trimester had a median gestational length reduced by 2.1 days (95% CI: -2.7 to -1.4) and a median term birth weight reduced by 294 g (95% CI: -325 to -262) compared with never-smokers. Conclusions Daily snuff use through the last trimester reduced the median gestational length by more than three days. Snuff reduced birth weight, but not as much as smoking, suggesting that the predominant effect of smoking on fetal growth is not through nicotine but through the additional toxic chemicals in cigarettes or by reduced oxygen supply to the fetus.

Abstract Background Fetal alcohol spectrum disorder (FASD) is a significant public health concern, yet there is no internationally agreed set of diagnostic criteria or summary of underlying evidence to inform diagnostic decision-making. This systematic review assesses associations of prenatal alcohol exposure (PAE) and outcomes of diagnostic assessments, providing an evidence base for the improvement of FASD diagnostic criteria. Methods Six databases were searched (inception–February 2023). Case-controls or cohort studies examining associations between participants with/without PAE or a FASD diagnosis and the domains of physical size, dysmorphology, functional neurodevelopment and/or brain structure/neurology were included. Excluded studies were non-empirical, sample size

Abstract Background Maternal and child health is an important measure of national well-being. This study further explored the individual and combined effects of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on adverse birth weight-related outcomes. Methods A retrospective study was carried out at a maternal and child health hospital from 2018 to 2021, and a total of 17,506 eligible women were invited to participate. The associations of pre-pregnancy BMI and GWG with adverse birth outcomes were examined by using restricted cubic spline regression and binary logistic regression. Results Pre-pregnancy BMI and GWG had non-linear associations with low birth weight and macrosomia. They were associated with an increased risk of macrosomia (Pre-pregnancy BMI for OR = 1.170, 95%CI:1.144 to 1.197, P

OBJECTIVE The objective of the study was to determine the incidence, patterns, and risk factors for the development of retinopathy of prematurity (ROP) in infants weighing >1500 g at birth. MATERIALS AND METHODS A retrospective analysis was done of the ROP screening records between April 2019 and March 2022. All the infants with birth weight >1500 g who underwent ROP screening were included. Data collected included demographic details, details of the risk factors (respiratory distress syndrome [RDS], hypoxia, anemia, septicemia, patent ductus arteriosus, congenital heart disease [CHD], i.e., atrial septal defects or ventricular septal defects, and multiple gestations), and ocular examination findings. Statistical analyses included calculation of mean, range, Chi-square test, and bivariate logistic regression for associations of risk factors with ROP. RESULTS ROP was noted in 16.6% of the 336 eyes of 168 infants. The mean birth weight and mean gestational age (GA) of the infants were 1850 ± 33 g and 33.33 weeks ± 1.71 weeks, respectively. Eighteen eyes (32.1%) had Stage I, 17 eyes (30.35%) had Stage II, and 11 eyes (19.64%) had Stage III ROP in Zone II. Aggressive ROP was seen in 8 eyes (14.28%) and stage 5 ROP in two eyes (0.59%). Male gender, GA, CHD, and RDS showed a statistically significant association with the development of ROP in these infants. CONCLUSION ROP was seen in 16.66% of our subjects. Treatment was required in 6.25% of infants. Risk factors for the development of ROP were low gestational age, male gender, the presence of RDS, and congenital heart disease.

Abstract Background The positive correlation between embryo quality and pregnancy outcomes has been confirmed in many studies, but there are few on the impact of embryo quality on neonatal weight, especially among neonates from fresh IVF‒ET cycles in ART. Therefore, this study aimed to compare the birth weights of infants from different blastocyst grades in fresh IVF-ET cycles and explore related factors affecting birth weight. Methods The main outcome measure was singleton birth weight. A total of 1301 fresh cycles of single blastocyst transplantation and single live birth profiles were retrospectively analyzed and divided into four groups according to blastocyst quality: the excellent group (grade AA), which included 170 cycles; the good group (grade AB/BA), which included 312 cycles; the average group (grade BB/CA/AC), which included 559 cycles; and the poor group (grade BC/CB), which included 260 cycles. The relationships among cystic cavity expansion, endocytic cell mass, ectodermal trophoblast cell grade, and birth weight were studied. Multiple linear regression analysis was performed to investigate the relationship between blastocyst quality and neonatal birth weight and logistic regression for the risk factors for low birth weight newborns. Results With decreases in the blastocyst quality, including ICM, TE quality, and embryo expansion stage, birth weight declined, and Z scores correspondingly decreased. After adjusting for confounders, the average and poor groups (P = 0.01 and P = 0.001, respectively) and blastocysts with TE grade C (P = 0.022) resulted in singletons with lower birth weight. Additionally, the poor group and blastocysts with Grade C TEs had a greater chance of leading to low birth weight infants compared with the other groups. Conclusion Our findings indicated that excellent and good-grade blastocyst transplantation could achieve better pregnancy outcomes and that average and poor-grade blastocyst transplantation, especially with grade C TEs, were associated with single birth weight loss. No association was found between the embryo expansion stage or ICM quality and neonatal birth weight.

ObjectiveTo investigate the birth weight of newborns and obesity status of preschool children in Tianjin, explore the key influencing factors of childhood obesity, and provide a basis for precise obesity prevention. MethodsFrom May 2015 to October 2016, data on newborns born in Tianjin were collected to establish a birth cohort. The growth and development of 58 332 newborns from birth to 5 years old were tracked using the database of the Tianjin Maternal and Child Health System. According to birth weight, Z-scores were calculated; and small for gestational age (SGA), appropriate for gestational age (AGA), or large for gestational age (LGA) were assessed. Height and weight were measured and recorded at 8 observation time points: 0.5, 1, 1.5, 2, 2.5, 3, 4, and 5 years old. Body mass index (BMI) and Z-scores were calculated to assess obesity occurrence. ResultsThe average gestational age at birth in the cohort was (39.56 ± 1.05) weeks, with 29 898 male infants (51.25%) and 28 343 female infants (48.75%). Based on the sex, gestational age and weight at birth, the cohort was divided into 3 groups: 2 979 SGA infants (5.11%), 48 382 AGA infants (82.94%), and 6 971 LGA infants (11.95%). During the continuous follow-up from birth to 5 years old, the lowest obesity incidence was 7.35% (3 130/42 604) at 2.5 years old and 7.41% (3 258/43 948) at 3 years old. The obesity rates of LGA children at 0.5, 1, 1.5, 2, 2.5, 3, 4, and 5 years old were consistently higher than those of AGA and SGA children of the same age. In the underweight group, the obesity rate of SGA children at age 5 (4.76%) was higher than that of AGA children (3.79%). In the obesity group, the obesity rate of SGA children at age 5 (32.26%) was higher than that of AGA children (22.67%) and LGA children (26.49%). Being SGA at birth increased the risk of catch-up growth at 0 – 6 months of age (univariate analysis OR = 5.309, 95%CI: 4.756 – 5.926, P < 0.001; multivariate analysis AOR = 5.314, 95%CI: 4.760 – 5.933, P < 0.001). Being LGA at birth increased the risk of obesity in children aged 0.5 – 5 in the normal-weight and overweight groups (all P < 0.001) and increased the risk of obesity in children of underweight mothers before age 2 (including age 2) (P < 0.05), as well as the risk of obesity in children of obese mothers before age 5 (not including age 5) (P < 0.05). ConclusionDuring prenatal examinations, fetal intrauterine development should be closely monitored, and birth weight should be scientifically controlled. Avoiding the delivery of SGA or LGA infants will be beneficial for the prevention and control of childhood obesity.

Background Adults who were born prematurely (

Background: Gestational pesticide exposure may negatively affect newborn outcomes. Prior results evaluating nonpersistent pesticides are inconsistent. Objective: To examine associations between gestational exposure to nonpersistent pesticides and newborn outcomes and identify critical windows of susceptibility. Study Design: In a Ghanaian pregnancy cohort, we measured select biomarkers of organophosphate, pyrethroid, and herbicide pesticides in repeated urine samples (1–5/participant). We developed a new model for assessing critical windows of vulnerability from irregularly-timed measurements of nonpersistent pesticides, leveraging strengths from multiple informant and distributed lag models. We estimated associations of biomarker concentrations with newborn anthropometrics and gestational length, adjusting for confounders and exploring effect modification by infant sex and placental malaria. Results: 1,211 pregnant women contributed 3,786 gestational urinary samples. In models assuming constant associations with exposures across pregnancy, in a given week a doubling of 3-phenoxybenzoic acid (pyrethroid biomarker) was associated with a −15.8 g difference in birth weight (95 % CI:-28.1,-3.6), and a doubling of the 2,4-dichlorophenoxyacetic acid (2,4-D, herbicide biomarker) was associated with an 11.1 g increase in birth weight (95 % CI:1.0,21.1). In time-varying models, significant associations were identified for pyrethroid exposure measured between weeks 16–27, and for 2,4-D exposure measured during weeks 25–33. Organophosphates were not associated with birth weight. No associations were found for birth length or head circumference for any pesticide. In constant association models, a doubling of weekly 2,4-D was associated with a 0.05 week increase in gestational length (95 %CI:0.01,0.09); no associations were found with other biomarkers. Conclusions: We identified associations between gestational exposure to nonpersistent pesticides and both birth size and gestational length. Extending multiple informant models to account for the complex data structure allowed us to discern effects in opposing directions by distinct pesticide classes. While estimated effects for a given week were modest, prolonged or repeated exposures could result in larger cumulative impacts.

IntroductionExploring modifiable and non-modifiable determinants—like sex of new-borns, maternal characteristics, and lifestyle—of maternal and child health is a priority in Public Health. Understanding these sex-based differences is essential for tailored care and informed public health policies.MethodsThe present study aimed to delineate sex disparities in delivery and neonatal characteristics within the “MAMI MED” cohort, an ongoing prospective study involving mother–child pairs from Catania, Italy. The analysis included 1,090 mother–child pairs.ResultsThe comparison of birth weight and birth length distribution showed some differences between sexes, confirmed by higher birth weight (β = 0.121; 95% CI = 0.071–0.172) and greater birth length (β = 0.659; 95% CI = 0.360–0.958) in males compared to females. However, the comparison of small and adequate for gestational age (SGA vs. AGA) revealed that the likelihood of being SGA was higher in males than in females (OR = 1.592; 95% CI = 1.005–2.563).DiscussionThus, the focus should be on improving the assessment of gender-based differences in diagnostic criteria and incorporating gender-specific aspects into existing preventive guidelines to deeply understand the effect of gender disparities and risk factors on maternal-child health.

Lamb survivability is an important trait from both an economic and animal welfare perspective. Five breeds at the U.S. Sheep Experiment Station were evaluated for survival to weaning and included 74,448 records from 43 years. Objectives were to evaluate 1) the influence of lamb and littermate competition on lamb survivability to 3 d and 120 d (weaning); 2) the influence of within-litter competition on birth weight; 3) the relationship between within-litter birth weight deviation and lamb survivability, 4) the influence of ewe age on lamb survivability and birth weight, and 5) reasons for and timing of lamb loss. Sex of littermate(s) had an impact on lamb survivability, which was more pronounced for triplets than for twins. Although not significant, female birth weights were lighter in mixed-sex litters than all-female litters. Within-litter birth weight deviation had an impact on lamb survivability with lambs from below mean weight litters that were more than 1 kg lighter than the litter having less than a 50% chance of survival. Both young and old ewes had lower lamb survival than mid-age ewes. Reasons for lamb loss differed depending on the age of the lamb with weak and trauma categories resulting in early loss and predation resulting in later loss. This study provides insight into within-litter competition for use in future genetic evaluation.

Background: This study explores the link between a mother’s dietary variety score and her prenatal eating patterns, focusing on the potential impact on her health and the likelihood of a low-birth-weight baby. Methods: Mothers at the Ganga Medical Centre and Hospitals in Coimbatore, Tamil Nadu, were interviewed to measure bio-social variables, including pre-pregnancy weight, height, BMI, total weight gain, and birth weight. Low birth weight was the main measure of interest. Results: The study found that 63.33% of neonates had a low birth weight, with 68% preterm and 32% late due to IUGR. 45% of mothers had a low BMI during pregnancy and pregnancies. Conclusion: Nutrition programs should prioritize screening and treating at-risk women, reducing the low-birth-weight infant burden, and promoting better maternal protein intake to improve baby birth weight.

Background: Early and delayed puberty are both associated with adverse health and psychosocial outcomes. Objectives: We assessed the impact of provision of small-quantity lipid-based nutrient supplement (SQ-LNS) to mothers during pregnancy and 6 mo postpartum and to their children aged 6–18 mo, on pubertal status. Methods: This study was a follow-up to a partially double-blind randomized controlled trial. At ≤20 wk, 1320 females were randomly assigned to receive daily: iron and folic acid during pregnancy and placebo 0–6 mo postpartum; or multiple micronutrients during pregnancy and 0–6 mo postpartum; or SQ-LNS during pregnancy and 0–6 mo postpartum and to their children from 6 to 18 mo. We re-enrolled 966 and 919 children at 9–11 y and 11–13 y, respectively. We calculated a total pubertal status score based on the Petersen Pubertal Development Scale (PDS) to assess growth spurt, skin changes, body hair, facial hair, voice break, breast development, and menstruation. Pubertal status was regressed on child’s age to generate age-adjusted PDS z-scores (aPDSZ); we performed interaction and mediation analyses. Results: Mean ± standard deviation aPDSZ did not differ between the SQ-LNS and non-LNS groups at 9–11 y (0.01 ± 0.95 compared with –0.01 ± 0.98; P = 0.958) but was more advanced in the SQ-LNS group at 11–13 y (0.07 ± 1.04 compared with –0.04 ± 0.98; P = 0.049) in the adjusted model. The effect of SQ-LNS varied by sex (P-interaction = 0.003) and household asset index z-score (P-interaction = 0.002): Puberty was more advanced in the SQ-LNS compared with non-LNS group among females (P = 0.007) but not males (P = 0.877), and within lower (P = 0.002) than average (P = 0.436) and higher (P = 0.332) socioeconomic households. Conclusion: Provision of SQ-LNS during the first 1000 d of life advanced pubertal status among females. Trial registration number: This trial was registered at clinicaltrials.gov as NCT00970866 (https://clinicaltrials.gov/ct2/show/record/NCT00970866).

IntroductionGlobally, 2.4 million neonates died in their first month of life in 2019 with approximately 6,700 neonatal deaths every day. Ethiopia is 4th among the top 10 countries with the highest number of neonatal deaths. Yet, there are few prospective studies on neonatal mortality in the central region of Ethiopia. Hence, to develop evidence-based, locally tailored intervention strategies, it is necessary to evaluate neonatal survival status and mortality predictors, including birth weight. Therefore, the current study aims to assess survival status and factors predicting the survival of neonates in the Silt’e zone, Ethiopia.MethodsAn institution-based prospective cohort study design was employed from 1 May to 30 July 2022. Data were collected from term neonates who were enrolled according to their order of health facility visit and then followed by data collectors in their homes. Data were analyzed using STATA version 14.1. Neonatal survival was presented using the Kaplan–Meier survival curve. The crude and adjusted associations were evaluated using the Cox proportional-hazards model, presented with a 95% confidence interval (CI), and a P-value

AimsTo evaluate the relation between maternal concentrations of progranulin (PGRN), adipocyte fatty acid-binding protein (AFABP), brain-derived neurotrophic factor (BDNF), and fibroblast growth factor 21 (FGF21) throughout pregnancy with neonatal weight and length at birth and at one month of age, as well as with the percentage of fat mass at one month of age. Besides, we evaluated the association between maternal organokine concentrations with pregestational nutritional status and gestational weight gain (GWG).MethodsLongitudinal study of 100 healthy pregnant women and their neonates. Conventional biochemical tests were performed and maternal organokine concentrations were measured by ELISA. Neonatal percent fat mass was determined using the PEA POD system, and weight and length were measured using a soft tape measure and a baby scale. Multiple linear regression models were made to predict neonatal anthropometric measurements and adiposity.ResultsIn all women, PGRN concentrations significantly increased as pregnancy progressed, while AFABP concentrations increased until the third trimester and the highest BDNF concentrations were observed in the second trimester of pregnancy. In contrast, FGF21 concentrations did not change during pregnancy. Only maternal obesity was associated with some differences in AFABP and FGF21 concentrations. Gestational age at birth, maternal age and third-trimester PGRN concentrations predicted weight (gestational age at birth: β=0.11; maternal age: β=-0.033; PGRN: β=0.003, p

Producing calves with higher economic value by utilising semen from beef breeds in dairy herds (Beef-on-Dairy, BoD) has become more common in recent times. Such crossbreed calves promise better carcass conformation and higher consumer acceptance due to the better flavour, but the widespread adaptation of BoD requires careful consideration of the sire breed to maximise the benefits. In this regard, two major traits of interest are calving difficulty and gestation length due to associated costs. In this study, 3 966 BoD calves from crossing Holstein dams with beef sires of the breeds Angus (n = 811), Belgian Blue (n = 2841), Limousin (n = 169) and Wagyu (n = 145) from 122 farms were evaluated to determine differences in calving difficulty and gestation length using binary logit and linear regression models. Lowest calving difficulty was observed for Wagyu crossbreds while Limousin crossbreds had the highest calving difficulty incidences. Selected sires from Angus and Belgian Blue breeds were also compared using chi-square analysis for differences in calving difficulty. The risk of calving difficulty was 1.94 times higher for male calves. Heifers had a significantly higher risk for calving difficulty when compared with the multiparous cows in the study. Calves with higher birth weight and longer gestation length were more prone to calving problems. For gestation length, Angus crossbreds had the shortest gestation (280.2 d), while the longest gestation (287.6) was observed in Limousin crossbreds. To maximise the benefits of the BoD breeding strategy, selecting appropriate sire breeds and within-breed sire selection for economically important traits, such as birth weight, appropriate gestation length, and reduced calving difficulty, may provide a viable solution.

Objective Preeclampsia (PE) increases the risk of many adverse maternal and fetal outcomes. This study was to investigate the correlation between epicardial adipose tissue (EAT) thickness and PE and birth weight.Methods This was a single-center retrospective study, 221 patients with PE were selected, and 81 women without hypertension and proteinuria were selected as a comparison. Echocardiogram was performed in their first prenatal examinations at 11–13 gestational weeks, and the thickness of EAT was measured. At the subsequent follow-up, the birth weight was recorded.Results EAT thickness was significantly elevated (6.60 ± 1.34 vs. 5.71 ± 1.79 mm, p

Objectives: Monitoring of fetal growth and estimation of birth weight is of clinical importance. During pregnancy, ultrasound fetal biometry values including femur length, head circumference, abdominal circumference, biparietal diameter are measured and used to place fetuses on “growth charts”. There is no simple growth-model-based, predictive formula in use for fetal biometry. Estimation of fetal weight at birth currently depends on ultrasound data taken a short time before birth. Study design: Our cohort (“Seethapathy cohort”) consists of ultrasound biometry measurements and other data for 774 pregnant women in Chennai, India, 2015–2017. We use the Gompertz model, a standard model for constrained growth, with just three intuitive parameters, to model the growth of fetal biometry, and a machine learning (ML) model trained on these parameters to predict birth weight (BW). Results: The Gompertz model convincingly fits the growth of fetal biometry values. Two Gompertz parameters—t0 (inflection time) and c (rate of decrease of growth rate)—seem universal to all fetuses, while the third, A, is an overall scale specific to each fetus, capturing individual variation. On the Seethapathy cohort we can infer A for each fetus from ultrasound data available by the 24 or 35 weeks. Our ML model predicts birth weight with

Background: Consumption of tobacco in its various forms is widespread and a serious public health issue globally. Although smoking is the predominant common method of tobacco use, the consumption of smokeless tobacco has increased in recent decades. Smokeless tobacco products are becoming more popular among women. In Pakistan, the overall prevalence of smokeless tobacco among males and females is 7%, out of which 10% are women which may be linked to poor reproductive outcomes and other health issues. Objective: The purpose of the study was to determine the effect of smokeless tobacco use during pregnancy on fetal birth weight. Methods: A case-control study was conducted at the five basic health units (BHU) of Thatta District, which were Garho, Ghora Bari, Dhabeji, Chattochand, and Jhimpeer from October 2022 – January 2023. A total of 300 mothers were included by consecutive sampling technique in the study and among them, 150 mothers who gave birth to a low-birth-weight baby i.e., birth weight < 2.5 kg were enrolled as a case, and another 150 mothers who gave birth to a normal birth weight baby i.e., birth weight ≥ 2.5 kg were enrolled as a control. Data collection involved face-to-face interviews utilizing a validated questionnaire, with strict adherence to ethical considerations throughout the study. Results: In a study of 300 participants from Thatta District’s five basic healthcare units, multivariate logistic regression revealed significant factors influencing tobacco use during pregnancy. Housewives had 1.862 times higher odds of tobacco use than employed individuals, and individuals aged 20–35 had 1.802 times higher odds than those aged 36-50. Smokeless tobacco, particularly most of the mothers in this study used gutka (47.3%) and chaliya (26%). Smokeless tobacco Gutka and Chaliya, increased the likelihood of tobacco use during pregnancy. Considering the frequency of smokeless tobacco use and healthcare provider recommendations emerged as important determinants. Conclusion: Our study underscores the prevalence of smokeless tobacco use during pregnancy in Thatta, Karachi, Pakistan, with significant implications for low-birth-weight babies. This highlights the need for targeted public health interventions, like antenatal care, alongside further research to inform evidence-based strategies for maternal and child health promotion in the region

Zhuo-Ren Zhou, Yong Guo Department of Health Care, Guangdong Women and Children Hospital, Guangzhou, 511400, People’s Republic of ChinaCorrespondence: Yong Guo, Department of Health Care, Guangdong Women and Children Hospital, Guangzhou, 511400, People’s Republic of China, Tel +86 2039151521, Email geyong084@163.comObjective: This study aimed to assess the growth of full-term infants with different sizes at birth and examine catch-up and catch-down growth in their first year.Methods: This retrospective population-based cohort study was based on the Guangdong Provincial Women and Children Health Information System. 194797 full-term singleton live births were extracted. Measurements for weight and length were taken at birth, 6 months, and 12 months. The size-for-gestational age was categorized as small (SGA, < 10th centile), appropriate (AGA, 10th-90th centiles), or large (LGA, > 90th centile) based on the international newborn size for gestational age and sex INTERGROWTH-21st standards. Catch-up and catch- down growth were defined as a change in standard deviation in z-score greater than 0.67 in the growth curves.Results: Of the 194797 full-term singletons, the average gestational age was 39.28 ± 1.03 weeks, and the average weight of the newborns was 3205 ± 383 grams. 15632 infants were identified as SGA (8.0%) and 12756 were LGA (6.5%). At 1 year of age, catch-up growth in weight was observed in 63.0% of SGA infants, 29.5% of AGA infants, and 5.4% of LGA infants. Conversely, catch-down growth occurred in 3.3% of SGA infants, 17.8% of AGA infants, and 54.7% of LGA infants. The proportions of catch-up growth in length for SGA, AGA, and LGA infants within the first year were 31.4%, 22.5%, and 17.1%, respectively. Catch-up or catch-down growth predominantly occurred before 6 months of age. However, from 6 to 12 months, there was no significant variation in WAZ among children with different birth sizes.Conclusion: In their first year of life, full-term singleton live births tend towards regression to the mean in their postnatal weight and length. The average delay in the growth of LGA is compensated by an increase in it of the SGA. Early monitoring and intervention are crucial for optimizing growth in infants with different birth sizes.Keywords: growth status, infant, birth weight, catch-up growth

Abstract Background Human milk banks are essential facilities to provide donated human milk (DHM) to preterm and term infants with health complications. Little is known regarding milk bank donors and how their characteristics may influence the particularities of the donation process. The present study aims to assess characteristics of donors and their newborns to identify associations with the amount of DHM and initiation and donation time, during the first and second year of the milk bank operation in Córdoba, Spain. Methods This cross-sectional study was conducted in three periods: pre-opening of the milk bank (PRE) including all women who gave birth to a newborn between January – May 2017 and were hospital users; donors in the first year after the opening (Period 1 (P1): April 2019 – March 2020); and in the second year (P2: April 2020 – March 2021). For P1 and P2, DHM data were recorded. The relationships between donor and newborn characteristics and the donation process were examined using univariable and regression models. Results From 391 women interviewed in the PRE period, 55 (14%) showed intention to donate. In P1 and P2, there were 51 and 25 human milk (HM) donors, respectively. Age, gestational age (GA) and parity were similar between periods. In P2, a higher proportion of donors had higher education (P1: 46%; P2: 70.8%, p = 0.045). Around 40% of donors in both periods were on maternity leave. In P1, donors who had low birth weight infants (

Abstract Objective Early childhood caries has become a globally crucial oral health problem over the decades. Most studies have discussed the association between low birth weight and early childhood caries; however, studies focusing on high birth weight have been relatively limited. This study aimed to assess the impact of high birth weight on the incidence and severity of dental caries in 4–5-year-old children. Subjects and methods Study subjects included 491 children from a birth cohort study at 4–5 years of age. Data on dental caries, prenatal and perinatal factors, and socio-demographic determinants were recorded. Logistic regression models adjusted for potential confounders were performed to analyze the data. Two-sided P-value

Sanctions against a country could be a shock to the country's economy for a specific period. Iran has been subject to various sanctions for the past 40 years, and these sanctions have intensified since 2011. Unprecedented sanctions were imposed on Iranians after the United States withdrew from the Joint Comprehensive Plan of Action (JCPOA) agreement, and a disastrous economic situation was the outcome of this international issue. The present study aims to evaluate the impact of this situation on weight gain of pregnant mothers and birth weight as well as food security of their families. Methods: The data of pregnant women and newborns were extracted from Sina Electronic Health System (SinaEHR®) questionnaires. These questionnaires were completed by trained healthcare workers in comprehensive health service centers. The data of 266,182 pregnant women were collected through questionnaires from 19 comprehensive health centers related to Razavi Khorasan province and were prepared for statistical analysis. Then, data analysis was done using the statistical method of Generalized Estimating Equations (GEE) by SPSS software. Results: Examining the data of 266,182 pregnant mothers during the sanctions period of 2017 to 2020 in Iran shows that the weight gain of pregnant mothers (P

Abstract Background Gestational DNA methylation age (GAmAge) has been developed and validated in European ancestry samples. Its applicability to other ethnicities and associations with fetal stress and newborn phenotypes such as inflammation markers are still to be determined. This study aims to examine the applicability of GAmAge developed from cord blood samples of European decedents to a racially diverse birth cohort, and associations with newborn phenotypes. Methods GAmAge based on 176 CpGs (Haftorn GAmAge) was calculated for 940 children from a US predominantly urban, low-income, multiethnic birth cohort. Cord blood DNA methylation was profiled by Illumina EPIC array. Newborn phenotypes included anthropometric measurements and, for a subset of newborns (N = 194), twenty-seven cord blood inflammatory markers (sandwich immunoassays). Results GAmAge had a stronger correlation with GEAA in boys (r = 0.89, 95% confidence interval (CI) [0.87,0.91]) compared with girls (r = 0.83, 95% CI [0.80,0.86]), and was stronger among extremely preterm to very preterm babies (r = 0.91, 95% CI [0.81,0.96]), compared with moderate (r = 0.48, 95% CI [0.34,0.60]) and term babies (r = 0.58, 95% CI [0.53,0.63]). Among White newborns (N = 51), the correlation between GAmAge vs. GEAA was slightly stronger (r = 0.89, 95% CI [0.82,0.94]) compared with Black/African American newborns (N = 668; r = 0.87, 95% CI [0.85,0.89]) or Hispanic (N = 221; r = 0.79, 95% CI [0.74,0.84]). Adjusting for GEAA and sex, GAmAge was associated with anthropometric measurements, cord blood brain-derived neurotrophic factor (BDNF), and monocyte chemoattractant protein-1 (MCP-1) (p

Abstract Background Existing data on maternal dietary patterns and birth weight remains limited and inconsistent, especially in non-Western populations. We aimed to examine the relationship between maternal dietary patterns and birth weight among a cohort of Chinese. Methods In this study, 4,184 mother-child pairs were included from the Iodine Status in Pregnancy and Offspring Health Cohort. Maternal diet during pregnancy was evaluated using a self-administered food frequency questionnaire with 69 food items. Principal component analysis was used to identify dietary patterns. Information on birth weight and gestational age was obtained through medical records. Adverse outcomes of birth weight were defined according to standard clinical cutoffs, including low birth weight, macrosomia, small for gestational age, and large for gestational age. Results Three maternal dietary patterns were identified: plant-based, animal-based, and processed food and beverage dietary patterns, which explained 23.7% variance in the diet. In the multivariate-adjusted model, women with higher adherence to the plant-based dietary patten had a significantly higher risk of macrosomia (middle tertile vs. low tertile: odds ratio (OR) 1.45, 95% CI 1.00-2.10; high tertile vs. low tertile: OR 1.55, 95% CI 1.03–2.34; P-trend = 0.039). For individual food groups, potato intake showed positive association with macrosomia (high tertile vs. low tertile: OR 1.72, 95% CI 1.20–2.47; P-trend = 0.002). Excluding potatoes from the plant-based dietary pattern attenuated its association with macrosomia risk. No significant associations was observed for the animal-based or processed food and beverage dietary pattern with birth weight outcomes. Conclusions Adherence to a plant-based diet high in carbohydrate intake was associated with higher macrosomia risk among Chinese women. Future studies are required to replicate these findings and explore the potential mechanisms involved.

ABSTRACT Aims/Introduction In 2021, the guidelines on gestational weight gain (GWG) were revised and increased by 2–3 kg in Japan. This study aimed to investigate whether the revised guidelines would increase the incidence of babies with excessive birth weight in mothers with diabetes. Materials and Methods This retrospective study included 369 deliveries of women with diabetes whose pre‐pregnancy body mass index was below 30 kg/m2 between 1982 and 2021. The primary outcome measure was large for gestational age (LGA). We compared the incidence of LGA between women who gained weight within the previous guidelines and women who gained weight within the revised guidelines. We also compared the incidence of macrosomia, preeclampsia, small for gestational age (SGA), and low birth weight. Results The incidence of LGA was not significantly different between women who gained weight within the revised guidelines and those within the previous guidelines (34.6% [95% confidence interval 25.6–44.6%] for the revised guidelines vs 28.9% [21.6–37.1%] for the previous guidelines; P = 0.246). Neither was the incidence of macrosomia or preeclampsia significantly different (8.7% [4.0–15.8%] vs 5.6% [2.5–10.8%] and 5.8% [2.1–12.1%] vs 6.3% [2.9–11.7%]; P = 0.264 and 0.824, respectively), while women who gained weight within the revised guidelines had a lower incidence of SGA (1.9% [0.2–6.8%] vs 10.6% [6.0–16.8%]; P = 0.001) and low birth weight (1.0% [0.02–5.2%] vs 7.0% [3.4–12.6%]; P = 0.023). Conclusions The revised GWG guidelines could be beneficial in women with diabetes in terms of delivering babies with appropriate birth weight.

Abstract The American Heart Association has updated its definition of cardiovascular health (CVH) with a new framework known as Life's Essential 8 (LE8). Although gestational CVH assessment has been recommended, its significance based on LE8 for birth outcomes is unknown. We thus evaluated the status of gestational CVH based on LE8 in 3036 pregnant women of the Shanghai Maternal-Child Pairs Cohort and the population of China Maternal Nutrition and Health Sciences Survey, and also examined the association between gestational CVH and child birth outcomes. We found that only a small proportion (12.84%) had high CVH, while 1.98% had low CVH in this cohort study. In adjusted models, a 10-point increase in the gestational CVH score, indicating a more favorable score, was associated with lower neonatal size such as birth weight (β: − 37.05 [95% confidence interval: − 52.93, − 21.16]), birth length (− 0.12[− 0.22, − 0.01]), weight-for-height z-score (− 0.07[− 0.12, − 0.03]), body mass index z-score (− 0.09 [− 0.13, − 0.04]), length-for-age Z-score (− 0.03 [− 0.06, − 0.01]), and weight-for-age z-score (− 0.08 [− 0.12, − 0.05]). Also, a 10-point increase in the gestational CVH score was associated with the lower risk of large for gestational age (LGA) (0.82 [0.73, 0.92]) and macrosomia infant (0.75 [0.64, 0.88]). CVH categories showed similar results. That is, better maternal CVH status in pregnancy was associated with lower neonatal size and lower risks for LGA and macrosomia in newborns.

Abstract Background Globally, perinatal mortality rates have decreased considerably in the last 30 years. However, in sub-Saharan African countries perinatal mortality remains a public health burden. Therefore, this study aimed to determine the Perinatal Mortality Rate and the factors associated with perinatal mortality in Beni City, Northeastern Democratic Republic of Congo. Methods A hospital-based retrospective cross-sectional study was conducted among 1394 deliveries that were documented in Beni General Referral Hospital from 2 January to May 31, 2022. The study was done in the conflict-ridden Beni city of the North Kivu Province. Analysis was done using Open Epi and SPSS version 22. Binary and Multivariate logistic regression analyses were performed. Odds ratio with 95% confidence interval was used to measure strength of association. Results Findings indicate that 60.7% of 1394 participants were below the age of 21 years, and 95.1% (1325) Beni residents. The Perinatal Mortality Rate was 42.3 per 1000 live births. Majority (51) of the postpartum women who experienced perinatal mortality didn`t have a history of perinatal mortality as compared to their counterparts. Multivariable analysis revealed that birth weight (AoR = 0.082, 95% CI 0.014–0.449, p

INTRODUCTION: Accurate prediction of birth weight is crucial for both fetuses and mothers. Low birth weight (birth weight < 2500g) and high birth weight (birth weight > 4000g) can lead to high perinatal mortality rates, various complications, and both short-term and long-term health outcomes such as chronic diseases. This article aims to propose a machine-learning solution to enhance the accuracy of birth weight prediction and assist clinicians in identifying potential risks before birth. METHODS: Seven hundred thirty different fetuses between weeks 15-40 were analyzed using clinical data. Nine different regression models from supervised machine learning methods, including logistic regression, support vector machine, decision tree, elastic net regressor, lasso regressor, ridge regressor, artificial neural network, random forest, and k-nearest neighbors algorithms, were employed to predict fetal birth weights based on gestational week, maternal age, gender, and ultrasound measurements, including biparietal diameter, abdominal circumference, and femur length. RESULTS: Our study revealed that abdominal circumference was the most influential parameter, while gender had the least impact. The performance of the nine different algorithms in birth weight prediction was compared, and the elastic net regressor algorithm exhibited the best predictive performance. The proposed model yielded a prediction result with an average absolute error percentage of 8.87% and an average error of +-284g. A new formula for the newborn weight prediction model was developed using the elastic net regressor machine learning method. DISCUSSION AND CONCLUSION: Our study demonstrates that the model created with the elastic net regressor algorithm can predict birth weight at any gestational age between weeks 15-40.

Background: Birth weight is one of the most important determinants of perinatal well -being and survival. It may be influenced by socioeconomic status among other factors. Objective: To evaluate the influence of parental socioeconomic status on birth weight distribution of term infants. Patients and Methods: Consecutive singleton, term newborns and their parents were recruited. Socioeconomic status was determined from parental education and occupation. Neonatal anthropometry was recorded soon after birth. The relationship between neonatal anthropometry and parental socioeconomic status was evaluated. Results: The mean birth weight of the 280 newborns was 3180g + 501 with a range of 1800g to 5000g. Most babies (181; 64.7%) weighed between 2500g and 3490g while 5.7% weighed less than 2500g and 20 (7.1%) were small for gestational age. Most parents (196; 70%) were in the upper classes I and II, 69 (24.6%)were in class III while 15 (5.4%)were in classes IV and V. Babies in the socioeconomic classes IV and V had significantly lower mean birth weight than babies in each of classes I, II and III (p = 0.005, 0.006 and 0.04 respectively). High maternal education and paternal occupation were associated with significantly higher mean birth weights (p = 0.007, 0.018 respectively). The low birth weight rate was significantly higher in the lower social classes III to V compared to the two upper classes (10.7% vs. 3.57%;, p =0.022. Conclusion: Disadvantaged socioeconomic status was associated with lower mean birth weights with maternal education and paternal occupation exerting the higher influences.

Abstract Background Gestational exposure to toxic environmental chemicals and maternal social hardships are individually associated with impaired fetal growth, but it is unclear whether the effects of environmental chemical exposure on infant birth weight are modified by maternal hardships. Methods We used data from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a pan-Canadian cohort of 1982 pregnant females enrolled between 2008 and 2011. We quantified eleven environmental chemical concentrations from two chemical classes – six organochlorine compounds (OCs) and five metals – that were detected in ≥ 70% of blood samples collected during the first trimester. We examined fetal growth using birth weight adjusted for gestational age and assessed nine maternal hardships by questionnaire. Each maternal hardship variable was dichotomized to indicate whether the females experienced the hardship. In our analysis, we used elastic net to select the environmental chemicals, maternal hardships, and 2-way interactions between maternal hardships and environmental chemicals that were most predictive of birth weight. Next, we obtained effect estimates using multiple linear regression, and plotted the relationships by hardship status for visual interpretation. Results Elastic net selected trans-nonachlor, lead, low educational status, racially minoritized background, and low supplemental folic acid intake. All were inversely associated with birth weight. Elastic net also selected interaction terms. Among those with increasing environmental chemical exposures and reported hardships, we observed stronger negative associations and a few positive associations. For example, every two-fold increase in lead concentrations was more strongly associated with reduced infant birth weight among participants with low educational status (β = -100 g (g); 95% confidence interval (CI): -215, 16), than those with higher educational status (β = -34 g; 95% CI: -63, -3). In contrast, every two-fold increase in mercury concentrations was associated with slightly higher birth weight among participants with low educational status (β = 23 g; 95% CI: -25, 71) compared to those with higher educational status (β = -9 g; 95% CI: -24, 6). Conclusions Our findings suggest that maternal hardships can modify the associations of gestational exposure to some OCs and metals with infant birth weight.

Background: Hypertensive disorders during pregnancy pose significant risks to both maternal and fetal health. Maternal hypertension has the potential to affect all the systems of the newborn, including the hematological system. Objective: To identify deviations in hematological parameters and birth outcomes in babies born to mothers with hypertensive disorders of pregnancy. Materials and Methods: An observational case–control study was carried out on neonates born to hypertensive mothers in Niloufer Hospital, Hyderabad, India. The study was done over 18-month period from January 2021 to August 2022. The cases comprised babies born to mothers with hypertensive disorders of pregnancy, while controls were babies of normotensive mothers. The hematological parameters measured included hemoglobin (Hb) level, platelet count, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and white blood cell (WBC) count. Results: The neonates of hypertensive mothers had significantly lower levels of Hb (P = 0.02), WBC (P = 0.001), MCH (P = 0.01), and MCHC (P = 0.004). Also, platelet counts were significantly lower among neonates of hypertensive mothers (P = 0.001). They also had significantly lower birth weights than the controls (P = 0.01). Conclusion: This study pinpointed substantial changes in the hematological profile and birth outcomes of neonates born to mothers with hypertensive disorder of pregnancy. These findings underscored the importance of considering these alterations when interpreting hematological values in these infants, necessitating early detection and comprehensive healthcare strategies for neonates at high risk in India. Future research should consider the long-term outcomes of these hematological parameters to elevate the understanding and guide interventions.

Introduction: Retinopathy of Prematurity (ROP) significantly contributes to the statistics of blindness among babies born prematurely. Population-based studies of the disease in Africa is scanty with many African countries lacking screening guidelines. Aim: To review the current statistics of ROP in Africa and present a summary of the incidence as well as the disease screening criteria within Africa. Materials and Methods: An in-depth literature search was done on various databases following the guidelines provided by the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist for systematic review protocols. Some keywords guiding the search were “ROP,” “Retinopathy,” and “screening.” The International Prospective Register of Systematic Reviews (PROSPERO) registration (522296) was done, and databases were screened from inception up to December 2023 via African Journals Online (AJOL), Science Direct, Embase, Web of Science, Cumulated Index to Nursing and Allied Health Literature (CINAHL), PubMed, Ovid, and Medline. The inclusion criteria were English language studies about disease screening published from inception up to December 2023. Studies that did not include the number of babies screened or ROP screening criteria used, case studies, and duplicated studies were excluded. The Anatomical Quality Assessment tool (AQUA) was applied to confirm any bias and for reporting study results. Results: A total of 15 articles were included, with sample sizes ranging from 33 to 424 participants. Two countries (Kenya and South Africa) have national screening guidelines, while for the rest of the countries in Africa, ROP is screened as per on the agreement of the ophthalmologists at each hospital. Conclusion: The present review highlights the fact that ROP is the leading cause of blindness globally, yet there is little research being done on the statistics and screening of the disease. Many countries in Africa do not have national screening guidelines for the disease, which is a great challenge.

ABSTRACT Aims This study aimed to investigate the association of maternal birth weight (MBW) with early and late gestational diabetes mellitus (GDM). Methods A total of 69318 pregnant Japanese women were included in this birth cohort study. The associations between maternal birth weight and early gestational diabetes mellitus (diagnosed at

Abstract Background Nutrition exerts a fundamental role in the prevention of obesity (OB). The aim of this study was to assess the extent to which well recognized risk factors for early OB can be associated to overweight (OW) or OB under a standardized nutritional approach and surveillance in toddlers. Methods The eligible population was represented by 676 toddlers aged 24–36 months, assigned to 18 primary care pediatricians trained on nutritional issues who shared a standardized nutritional approach. Six-hundred-twenty-nine children (333 boys), mean age 27.8 ± 4.2 months were effectively included in this observational study. Parents received nutritional advice with particular emphasis to proteins and sugar composition supported by leaflets and reinforced at each visit. Body mass index was assessed at the age of 24–36 months. The following individual and family risk factors were considered: gestational age, birth weight, eutocic/caesarean delivery, milk feeding history, household smoking or antibiotics exposure, parents’ weight, height and educational level. Prevalence of OW/OB was compared to a group of 742 toddlers (373 boys) under usual care. Results Under a standardized nutritional counselling, 28.1% toddlers were classified as OW/OB compared to 36.9% toddlers under usual care (p = 0.005). In unadjusted models, parental OW/OB was significantly associated to OW/OB in toddlers (p

Achim Fieß,1,&ast; Sandra Gißler,1,&ast; Philipp S Wild,2– 4 Karl J Lackner,5 Thomas Münzel,6 Matthias Michal,7 Michael S Urschitz,8 Norbert Pfeiffer,1 Alexander K Schuster1 1Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 2Preventive Cardiology and Preventive Medicine - Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 3Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 4German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; 5Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 6Center for Cardiology – Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 7Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 8Division of Pediatric Epidemiology, Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany&ast;These authors contributed equally to this workCorrespondence: Achim Fieß, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, Mainz, 55131, Germany, Tel +49-6131-17-5150, Fax +49-6131-17-8495, Email Achim.fiess@gmail.comAbstract: This study investigates the association between self-reported birth weight (BW) and the prevalence of hypertensive retinopathy (HR) in a large population-based cohort in Germany, as part of the Gutenberg Health Study (GHS). The study involved analyzing fundus photographs of 6855 participants, aged 35 to 74, to assess signs of HR, classified according to the Mitchell-Wong Classification. The research aimed to explore the correlation between fetal growth restriction indicated by BW and the frequency of HR. The results showed that the frequency of HR did not significantly differ among groups with different BW ranges. In the univariable analysis, HR was initially associated with high BW, but this association disappeared after adjusting for age, sex, and cardiovascular risk factors. No association was found between low BW and HR. The study reveals novel insights as there are no prior population-based studies specifically exploring this association.Keywords: birth weight, hypertensive retinopathy, epidemiology, population-based study