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Juvenile idiopathic arthritis (JIA) is an umbrella term for seven distinct chronic immune-mediated diseases. Disease-modifying anti-rheumatic drugs (DMARD) are used to treat the underlying joint inflammation as well as extra-articular manifestations. Immunosuppression is a considerable side effect of the drugs. The main goal of this study was to investigate the effect of different JIA therapies on leukocyte subpopulations, which play a role in immune-defense. Three study groups were established. The first group consisted of JIA patients treated with methotrexate solely, the second one received a combination of methotrexate (MTX) and adalimumab (ADA). The control group was made up of the patients' healthy siblings. A total of 63 children were recruited. Fourty-one children with JIA and 22 healthy controls were included in the study. The absolute number of CD3+ T-cells was significantly elevated in patients treated with biological therapy compared to healthy controls (p2 = 0.017). In contrast, the number of CD56+ natural killer cells was significantly lower in children receiving biological therapy in comparison with healthy donors (p2 = 0.039). A significant alteration was also demonstrated between patients treated with MTX and MTX/ADA group concerning CD 19+ B-cells (p3 = 0.042). This is the first study that demonstrates significant alterations in the number of B-cells and T-cells with a relative decrease of NK-cell ratios in JIA patients receiving different DMARD therapy.Clinical Trial Registration:NCT03833271. 21.01.2019.

Selskyy P. R., Furdela M. Ya., Selskyy B. P. Нарушение клеточного звена общего иммунитета у больных с различными видами эндоцервикоза = Violation of the total cellular immunity in patients with different types of endocervicosis. Journal of Education, Health and Sport. 2016;6(4):31-38. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.49393 http://ojs.ukw.edu.pl/index.php/johs/article/view/3444 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.03.2016. Revised 20.03.2016. Accepted: 05.04.2016. Нарушение клеточного звена общего иммунитета у больных с различными видами эндоцервикоза П. Р. Сельський, М. Я. Фурдела, Б. П. Сельський Государственное высшее учебное заведение “Тернопольский государственный медицинский университет имени И.Я. Горбачевского МОЗ Украины”, Тернополь, Украина Резюме Проведено иммунологическое исследование 51 больной с эндоцервикозом. В первую группу вошли все больные с эндоцервикозом, вторую – только с простым эндоцервикозом (31,4 %), в третью (37,2 %) – с заживающим эндоцервикозом, а четвертая группа (31,4 %) охватывала женщин с прогрессирующим эндоцервикозом. Анализ клеточного звена иммунитета проводился с помощью моноклональных антител к антигенам лимфоцитов CD3, CD4, CD8 и CD19. Содержание большинства фенотипов лимфоцитов крови обследованных женщин с эндоцервикозом отличалось от нормальных. У больных с эндоцервикозом наблюдалось значительное угнетение клеточного звена иммунитета. Средний уровень CD3-лимфоцитов составил – (46,0±0,7) % против (64,5±2,8) % в контрольной группе (р