1. The etiology and differential diagnosis of 'autoimmune hepatitis-like liver disease' in children: a single-center retrospective study
- Author
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Di Ma, Xinglou Liu, Guo Ai, Wen Pan, Lingling Liu, Yuan Huang, Yi Liao, Yuanyuan Lu, Zhan Zhang, Hua Zhou, Zhihua Huang, Xingjie Hao, Sainan Shu, and Feng Fang
- Subjects
children ,autoimmune hepatitis ,serum globulin ,immunoglobulin G ,autoantibodies ,histology ,Pediatrics ,RJ1-570 - Abstract
BackgroundChildren with autoimmune hepatitis (AIH) often present with symptoms similar to those of other liver diseases. This study consists of a comparison between the clinical and histological characteristics of AIH and those of other four AIH-like liver diseases [i.e., drug-induced liver injury (DILI), gene deficiency, infectious liver disease and other etiology of liver disease], as well as an evaluation of the AIH scoring system's diagnostic performance.MethodsAll children with AIH-like liver disease at our center from January 2013 to December 2022 were included. The clinical and histological characteristics of the AIH group were retrospectively analyzed and compared with those of the other four groups.ResultsA total of 208 children were included and divided into AIH group (18 patients), DILI group (38 patients), gene deficiency group (44 patients), infectious liver disease group (74 patients), and other etiology group (34 patients). The antinuclear antibodies (ANA) ≥ 1:320 rate was significantly higher in the AIH compared to the other four groups after multiple testing correction (p 0.73) and the revised systems (AUC > 0.93) for AIH have good diagnostic performance, with the latter being superior (p
- Published
- 2024
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