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1. Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved]

Author

Florence Duffaud and Axel Le Cesne

Subjects
Review, Articles, Cancer Therapeutics, Gastrointestinal Cancers, gastrointestinal stromal tumours, tyrosine kinase inhibitors, microscopic complete resection
Abstract

Constitutive activating mutations in KIT and platelet-derived growth factor receptor α ( PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs.

Published
2017
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