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5 results on '"Basak, Amit"'

1. Effect of remote trigonal carbons on the kinetics of Bergman cyclization: synthesis and chemical reactivity of pyridazinedione-based enediynes

Author

Basak, Amit, Bag, Subhendu Sekhar, Majumdar, Pooja Anjali, Das, Amit Kumar, and Bertolasi, Valerio

Subjects
Pyridazine -- Chemical properties, Ring formation (Chemistry) -- Analysis, Carbon -- Chemical properties, Biological sciences, Chemistry
Abstract

The synthesis and chemical reactivity of pyridazinedione-based enediynes are presented. The single-crystal X-ray structures showed similar c,d distances (distance between the acetylenic carbons undergoing covalent connection in Bergman cyclization). more...

Published
2004

2. Which one is preferred: Myers-Saito cyclization of ene-yne-allene or Garratt-Braverman cyclization of conjugated bisallenic sulfone? A theoretical and experimental study

Author

Basak, Amit, Sanket Das, Mallick, Dibyendu, and Jemmis, Eluvathingal D.

Subjects
Benzene -- Structure, Benzene -- Chemical properties, Ring formation (Chemistry) -- Analysis, DNA -- Structure, DNA -- Chemical properties, Chemistry
Abstract

A competitive scenario between Myers-Saito (MS) and Garratt-Braverman (GB) cyclization is created in a molecule and high-level computations have shown a preference for GB over MS cyclization. The analysis has showed that the intramolecular self-quenching nature of the GB pathway has played a vital role in the complete preference for the reaction. more...

Published
2009

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3. Design, synthesis , and biological activity of unnatural enediynes and related analogous equipped with pH-dependent or phototriggering devices

Author

Kar, Moumita and Basak, Amit

Subjects
Antimitotic agents -- Structure, Antimitotic agents -- Research, Antineoplastic agents -- Structure, Antineoplastic agents -- Research, Ring formation (Chemistry) -- Analysis, Charge transfer -- Research, Sulfones -- Chemical properties, Sulfones -- Optical properties, Isomerization -- Analysis, Chemistry
Abstract

The unnatural enediynes are synthesized by means of pH and photo-irradiation dependent devices. The structures and synthesis strategies of these biologically important molecules are analyzed.

Published
2007

4. Chelation-controlled Bergman cyclization: synthesis and reactivity of enediynyl ligands

Author

Basak, Amit, Mandal, Subrata, and Bag, Subhendu Sekhar

Subjects
Chelates -- Chemical properties, Chemical research -- Analysis, Chemical tests and reagents -- Chemical properties, Ligands -- Properties, Organometallic compounds -- Chemical properties, Organometallic compounds -- Composition, Reactivity (Chemistry) -- Analysis, Ring formation (Chemistry) -- Analysis, Chemistry
Abstract

The authors review the publications on Bergman cyclization. The topics include the analysis of the enediyne design strategies, metal-ion-induced Bergman cyclization and its mediation by organometallic reagents. more...

Published
2003

5. Beta-secondary kinetic isotope effects in the clavaminate synthase-catalyzed oxidative cyclization of proclavaminic acid and in related azetidinone model reactions

Author

Iwata-Reuyl, Dirk, Basak, Amit, and Townsend, Craig A.

Subjects
Catalysts -- Research, Chemical reaction, Rate of -- Research, Enzymes -- Research, Isotopes -- Research, Chemistry
Abstract

Research is presented demonstrating the catalysis of three distinct oxidative reactions during the biosynthesis of clavulanic acid by an Fe(II)/alpha-ketoglutarate-dependent oxygenase.

Published
1999