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2 results on '"Bhattacharyya, Sharmistha"'

1. Actual Power Quality: Enexis invests in a measurement program to fully understand the performance of its distribution network

Author

Bhattacharyya, Sharmistha

Subjects
Electric vehicles -- Measurement, Company investment, Electronics and electrical industries
Abstract

To promote the sustainable-energy transition, an increasing number of photovoltaic rooftop panels and wind turbines are being connected to low-voltage and medium-voltage networks. The integration of these renewable sources of [...]

Published
2020

2. Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells

Author

Balakathiresan, Nagaraja Sethuraman, Bhattacharyya, Sharmistha, Gutti, Usha, Long, Robert P., Jozwik, Catherine, Huang, Wei, Srivastava, Meera, Pollard, Harvey B., and Biswas, Roopa

Subjects
Epithelial cells -- Physiological aspects, Epithelial cells -- Genetic aspects, Epithelial cells -- Research, Interleukin-8 -- Health aspects, Cystic fibrosis -- Risk factors, Cystic fibrosis -- Genetic aspects, Cystic fibrosis -- Care and treatment, Cystic fibrosis -- Research, Biological sciences
Abstract

Cystic fibrosis (CF) is due to mutations in the CFTR gene and is characterized by hypersecretion of the proinflammatory chemokine IL-8 into the airway lumen. Consequently, this induces the highly inflammatory cellular phenotype typical of CF. Our initial studies revealed that IL-8 mRNA is relatively stable in CF cells compared with those that had been repaired with [WT]CFTR (wild-type CFTR). Relevantly, the 3'-UTR of IL-8 mRNA contains AU-rich sequences (AREs) that have been shown to mediate posttranscriptional regulation of proinflammatory genes upon binding to ARE-binding proteins including Tristetraprolin (TTP). We therefore hypothesized that very low endogenous levels of TTP in CF cells might be responsible for the relative stability of IL-8 mRNA. As predicted, increased expression of TTP in CF cells resulted in reduced stability of IL-8 mRNA. An in vitro analysis of IL-8 mRNA stability in CF cells also revealed a TTP-induced enhancement of deadenylation causing reduction of IL-8 mRNA stability. We conclude that enhanced stability of IL-8 mRNA in TTP-deficient CF lung epithelial cells serve to drive the proinflammatory cellular phenotype in the CF lung. cytokines; chemokines; inflammation; gene regulation

Published
2009

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