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2 results on '"Clair, Mark J."'

1. Myocardial matrix metalloproteinase activity and abundance with congestive heart failure

Author

Coker, Mytsi L., Thomas, Chadwick V., Clair, Mark J., Hendrick, Jennifer W., Krombach, R. Stephen, Galis, Zorina S., and Spinale, Francis G.

Subjects
Congestive heart failure -- Physiological aspects, Metalloenzymes -- Physiological aspects, Heart ventricle, Left -- Physiological aspects, Extracellular matrix -- Physiological aspects, Biological sciences
Abstract

The relative abundance of specific matrix metalloproteinases (MMPs) was investigated during congestive heart failure (CHF). With pacing CHF, left ventricular (LV) myocardial zymographic activity for the substrate gelatin increased by 119% and for the substrate collagen III by 153% over controls. Caseinolytic activity also increased with pacing CHF by 139% over controls. Thus, LV myocardial MMP activity and abundance increased with pacing-induced CHF.

Published
1998

2. Bradykinin Degradation and Relation to Myocyte Contractility

Author

Krombach, R. Stephen, McElmuray, III, James H., Gay, David M., Clair, Mark J., Mukherjee, Rupak, Goldberg, Aron T., Baicu, Simona C., and Spinale, Francis G.

Subjects
Bradykinin -- Physiological aspects, Heart -- Contraction, Health
Published
2000

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