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The article studies retinitis pigmentosa (RP), a genetically heterogeneous group of progressive neurodegenerative disease that result in dysfunction and death of rod and cone photoreceptors in retina. Findings reveal additional role of ubiquitin-proteasome protein-degradation pathway in observing neuronal health.

Author(s): Kathryn E. Lafond 1,2,*, Harish Nair 3,4, Mohammad Hafiz Rasooly 5, Fátima Valente 6, Robert Booy 7, Mahmudur Rahman 8, Paul Kitsutani 1, Hongjie Yu 9, Guiselle Guzman 10, [...], Background The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has been used to estimate influenza burden. In this analysis, we use surveillance data to provide an estimate of influenza-associated hospitalizations among children worldwide. Methods and Findings We aggregated data from a systematic review (n = 108) and surveillance platforms (n = 37) to calculate a pooled estimate of the proportion of samples collected from children hospitalized with respiratory illnesses and positive for influenza by age group ( Influenza was associated with 10% (95% CI 8%-11%) of respiratory hospitalizations in children Conclusions Influenza is an important contributor to respiratory hospitalizations among young children worldwide. Increasing influenza vaccination coverage among young children and pregnant women could reduce this burden and protect infants