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1. Structure of both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor probed by FTIR spectroscopy and hydrogen exchange

Author

Methot, Nathalie, Demers, Caroline N., and Baenziger, John E.

Subjects
Acetylcholine -- Receptors, Nicotinic receptors -- Research, Fourier transform infrared spectroscopy -- Research, Biological sciences, Chemistry
Abstract

The structural changes that lead to both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor (nAChR) have been determined. The Fourier transformed infrared spectra of nAChR have been recorded as a function of time and after prolonged exposure to (super 2)H20 buffer in the presence and absence of Carb and tetracaine. The spectra for the nAChR reconstituted into lipid membranes were also recorded. The results showed that the secondary structure of the nAChR is not affected by channel inactivation.

Published
1995

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