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19 results on '"Donnelly, J Peter"'

1. Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients

Author

Plantinga, Theo S., van der Velden, Walter J.F.M., Ferwerda, Bart, van Spriel, Annemiek B., Adema, Gosse, Feuth, Ton, Donnelly, J. Peter, Brown, Gordon D., Kullberg, Bart-Jan, Blijlevens, Nicole M.A., and Netea, Mihai G.

Subjects
Genetic polymorphisms -- Research, Genetic polymorphisms -- Control, Candida -- Research, Candida -- Physiological aspects, Candidiasis -- Prevention, Hematopoietic stem cells -- Transplantation, Hematopoietic stem cells -- Usage, Hematopoietic stem cells -- Patient outcomes, Health, Health care industry
Published
2009

3. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) consensus group

Author

Pauw, Ben De, Walsh, Thomas J., Donnelly, J. Peter, Stevens, David A., Edwards, John E., Calandra, Thierry, Pappas, Peter G., Maertens, Johan, Lortholary, Olivier, Kauffman, Carol A., Denning, David W., Patterson, Thomas F., Maschmeyer, Georg, Bille, Jacques, Dismukes, William E., Herbrecht, Raoul, Hope, William W., Kibbler, Christopher C., Kullberg, Bart Jan, Marr, Kieren A., Munoz, Patricia, Odds, Frank C., Perfect, John R., Restrepo, Angela, Ruhnke, Markus, Segal, Brahm H., Sobel, Jack D., Sorrell, Tania C., Viscoli, Claudio, Wingard, John R., Zaoutis, Theoklis, and Bennett, John E.

Subjects
Mycoses -- Prognosis, Mycoses -- Research, Cancer -- Research, Cancer -- Care and treatment, Health, Health care industry
Published
2008

4. Optimization of the cutoff value for the aspergillus double-sandwich enzyme immunoassay

Author

Maertens, Johan A., Klont, Rocus, Masson, Christine, Theunissen, Koen, Meersseman, Wouter, Lagrou, Katrien, Heinen, Christine, Crepin, Brigitte, Van Eldere, Johan, Tabouret, Marc, Donnelly, J. Peter, and Verweij, Paul E.

Subjects
Aspergillosis -- Diagnosis, Immunoenzyme technique -- Standards, Reference values (Medicine) -- Research, Health, Health care industry
Published
2007

6. Antimicrobial therapy to prevent or treat oral mucositis

Author

Donnelly, J Peter, Bellm, Lisa A., Epstein, Joel B., Sonis, Stephen T., and Symonds, R Paul

Subjects
Peptides -- Analysis, Chemotherapy -- Analysis, Anti-infective agents -- Analysis, Stomatitis -- Prevention, Stomatitis -- Analysis, Radiotherapy -- Analysis, Cancer -- Chemotherapy, Cancer -- Analysis, Pain -- Care and treatment, Pain -- Analysis
Published
2003

7. Human platelets attenuate aspergillus species via granule-dependent mechanisms

Author

Perkhofer, Susanne, Kehrel, Beate E., Dierich, Manfred P., Donnelly, J. Peter, Nussbaumer, Walter, Hofmann, Johann, von Eiff, Christof, and Lass-Florl, Cornelia

Subjects
Aspergillus -- Research, Aspergillus -- Physiological aspects, Blood platelets -- Genetic aspects, Microscope and microscopy -- Usage, Health
Published
2008

8. Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration

Author

Lutgens, Ludy C.H.W., Blijlevens, Nicole M.A., Deutz, Nicolaas E.P., Donnelly, J. Peter, Lambin, Philippe, and de Pauw, Ben E.

Subjects
Citrulline -- Research, Citrulline -- Analysis, Permeability -- Research, Permeability -- Analysis, Intestinal mucosa -- Complications and side effects, Intestinal mucosa -- Research, Intestinal mucosa -- Care and treatment, Intestinal mucosa -- Analysis, Small intestine cancer -- Research, Small intestine cancer -- Care and treatment, Small intestine cancer -- Diagnosis, Small intestine cancer -- Analysis, Health
Published
2005

9. Empiric therapy in the persistently febrile patient with neutropenia: caspofungin vs liposomal amphotericin

Author

Deresinski, Stan and Donnelly, J. Peter

Subjects
Amphotericin B -- Drug therapy, Neutropenia -- Care and treatment, Antifungal agents, Health
Abstract

Synopsis: Overall, caspofungin was at least as effective as liposomal amphotericin B for empiric therapy in persistently febrile neutropenic patients. Caspofungin therapy was associated with greater survival 7 days after [...]

Published
2004

10. Perspectives on cancer therapy-induced mucosal injury

Author

Sonis, Stephen T., Elting, L.S., Keefe, D., Peterson, D.E., Schubert, Mark, Hauer-Jensen, Martin, Bekele, B. Nebiyou, Raber-Durlacher, Judith, Donnelly, J. Peter, and Rubenstein, Edward, B.

Subjects
Mucociliary system -- Research, Mucociliary system -- Diseases, Cancer -- Care and treatment, Cancer -- Research, Cancer -- Complications and side effects, Health
Published
2004

12. Halo sign and improved outcome

Author

Verweij, Paul E., van Die, Lya, Donnelly, J. Peter, Greene, Reginald E., Schlamm, Haran T., Oestmann, Jorg-W., Stark, Paul, Durand, Christine, Lortholary, Olivier, Wingard, John R., Herbrecht, Raoul, Ribaud, Patricia, Patterson, Thomas F., Troke, Peter F., Denning, David W., Bennett, John E., De Pauw, Ben E., and Rubin, Robert H.

Subjects
Pulmonary aspergillosis -- Care and treatment, Amphotericin B -- Dosage and administration, Amphotericin B -- Research, Health, Health care industry
Published
2007

14. Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer: a multicenter randomized trial

Author

De Pauw, Ben E., Deresinski, Stanley C., Feld, Ronald, Lane-Allman, Elizabeth F., and Donnelly, J. Peter

Subjects
Antipyretics -- Evaluation, Ceftazidime -- Evaluation, Piperacillin -- Evaluation, Tobramycin -- Evaluation, Fever -- Drug therapy, Cancer patients -- Care and treatment, Health
Abstract

* Objective: To compare piperacillin and tobramycin with ceftazidime alone for the empiric treatment of fever in the neutropenic patient without evidence of skin infections or anaerobic infections. * Design: A multicenter, randomized, controlled trial. * Patients: 876 febrile, neutropenic episodes in 696 patients (83% acute leukemia or bone marrow transplantation); 92 episodes were excluded from analysis because of protocol violation. * Interventions: Patients received either intravenous ceftazidime (2 g every 8 h) or piperacillin (12 to 18 g/d in 4 to 6 divided doses plus tobramycin (1.7 to 2.0 mg/kg body weight every 8 h). Treatment could be modified at any time at the discretion of the investigator. * Measurements: Percentage of satisfactory response, eradication of the infecting organism, development of superinfections, and occurrence of adverse events. * Results: As a single agent, ceftazidime was as effective as the combination of piperacillin and tobramycin (62.7% satisfactory responses compared with 61.1%; odds ratio, 1.07; 95% CI, 0.79 to 1.44; P > 0.2). Equivalent responses were also obtained in episodes of profound neutropenia (odds ratio, 0.76; CI, 0.43 to 1.33; P > 0.2). Infectious mortality was 6% for ceftazidime and 8% for the combination therapy. Eradication of the infecting organisms was achieved in 79% of bacteremic episodes treated with ceftazidime compared with 68% of the episodes treated with the combination therapy (odds ratio, 1.76; CI, 0.92 to 3.38; P = 0.08), and rates for gram-negative rod bacteremia were also similar (95% compared with 77%; odds ratio, 5.25; CI, 1.0 to 27.5; P = 0.03). Superinfections developed in 38 episodes in each group. An adverse event occurred in 8% of episodes treated with ceftazidime compared with 20% of episodes treated with combination therapy P < 0.001). * Conclusion: Ceftazidime alone was as effective but safer than the combination of piperacillin and tobramycin for the empiric treatment of febrile, neutropenic patients, even those with profound and prolonged granulocytopenia., Ceftazidime has been shown to be safer than and just as effective as the combination of piperacillin and tobramycin in treating cancer patients with fever and neutropenia who do not have a staphylococcal or anaerobic infection. Neutropenia is a reduced level of white blood cells that is also known as granulocytopenia and agranulocytosis. Most of the 696 patients studied had acute leukemia or a bone marrow transplant. The combination of piperacillin and tobramycin had a much higher rate of toxicity than did ceftazidime, especially on kidney function. Resistance to ceftazidime developed in only 3% of the patients. An adverse event occurred in 8% of the cases in which ceftazidime was used, as opposed to 20% of the cases with piperacillin and tobramycin therapy.

Published
1994

15. Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt

Author

Anaissie, Elias J., Segal, Brahm H., Graybill, John R., Arndt, Carola, Perfect, John R., Kleinberg, Michael, Pappas, Peter, Benjamin, Danny, Rubin, Robert, Aberg, Judith A., Adderson, Elisabeth E., Adler-Shohet, Felice C., Akan, Hamdi, Akova, Murat, Almyroudis, Nikolaos G., Alexander, Barbara D., Andes, David, Arrieta, Antonio, Baddley, John W., Barron, Michelle A., Belzberg, Howard, Boucher, Helen W., Boyce, Thomas G., Casadevall, Arturo, Chandrasekar, P.H., Cleary, John D., Cordonnier, Catherine, Cornely, Oliver A., Cuenca-Estrella, Manuel, Daly, Jennifer S., Daoura, Nicholas, Denning, David W., dePauw, Ben, Repentigny, Louis de, Dignani, Maria Cecilia, Dismukes, William E., Donnelly, J. Peter, Donowitz, Gerald R., Dupont, Bertrand, Drusano, George, Ellis, Michael, Espinel-Ingroff, Ana, Fishman, Jay A., Fleming, Rhonda, Forrest, Graeme, Ghannoum, Mahmoud, Goldman, Mitchell, Grazziutti, Monica, Greene, John N., Greenberg, Richard N., Gubbins, Paul O., Hadley, Susan, Herbrecht, Raoul, Hiemenz, John W., Hope, William, Hospenthal, Durane R., Husain, Shahid, Ito, James I., Jacobson, Robert M., Johnson, Melissa, Keating, Michael R., Kett, Daniel H., Knapp, Katherine, Kontoyiannis, Dimitrios P., Krcmery, Vladimir C., Larsen, Robert, Laverdiere, Michel, Ljungman, Per, Lortholary, O., Maertens, Johan, Marriott, Debbie, Mattiuzzi, Gloria, McGinnis, Michael R., Morris, Michele, Nucci, Marcio, Odds, Frank C., Pankey, George A., Patterson, Thomas, Pfaller, Mike, Razonable, Raymond R., Reboli, Annette C., Rinaldi, Michael G., Roberts, Glenn D., Tudela, Juan Luis Rodriguez, Rotstein, Coleman, Ruhnke, Markus, Schuster, Mindy, Shoham, Shmuel, Sia, Irene G., Siebel, Nita, Silviera, Fernanda, Singh, Nina, Sobel, Jack, Solomkin, Joseph S., Sorrell, Tania C., Steinbach, William J., Temesgen, Zelalem, Tortorano, AnnaMaria, Vartivarian, Shahe, VerWeij, Paul, Viscoli, Claudio, Viviani, Maria Anna, Walker, Randall C., Wheat, Joseph L., Wiley, Joseph, Williamson, Peter, Wingard, John R., Yu, Victor L., and Zaoutis, Theoklis

Subjects
Clinical trials -- Evaluation, Journalism, Medical -- Evaluation, Health, Health care industry
Published
2006

16. Galactomannan detection and diagnosis of invasive aspergillosis

Author

Donnelly, J. Peter and Leeflang, Mariske M.

Subjects
Pulmonary aspergillosis -- Diagnosis, Pulmonary aspergillosis -- Research, Bronchoalveolar lavage -- Analysis, Microbial polysaccharides -- Analysis, Health, Health care industry
Published
2010

17. Fever and Neutropenia: More Challenges than Changes in the Last 20 Years

Author

Donnelly, J. Peter

Subjects
Neutropenia -- Complications, Fever -- Health aspects, Health
Abstract

THE NUMBER OF NEUTROPENIC PATIENTS HAS INcreased considerably since Pizzo wrote his first editorial on fever in the immunocompromised host in 1983. Not only are there more patients being treated [...]

Published
2000

18. What a crab to diagnose and monitor invasive aspergillosis

Author

Donnelly, J. Peter

Subjects
Neutropenia -- Research, Aspergillosis -- Diagnosis, Aspergillosis -- Risk factors, Health
Abstract

Synopsis: Invasive aspergillosis among neutropenic patients could be reliably diagnosed using a commercial test Fungitell[TM] to detect the cell wall component (1->3)-[beta]-D-glucan of certain fungi, including Aspergillus. However, diagnosis was [...]

Published
2005

19. A widespread outbreak of Yersinia pseudotuberculosis O:3 infection from iceberg lettuce

Author

Donnelly, J. Peter

Subjects
Yersinia infections -- Risk factors, Lettuce -- Health aspects, Epidemics -- Risk factors, Epidemics -- Finland, Business, Health, Health care industry
Abstract

Synopsis: An outbreak of food poisoning by Yersinia pseudotuberculosis in Finland in October/November 1998 involved 46 cases and was traced to locally grown Iceberg lettuce. Source: Nuorti JP, et al. [...]

Published
2004

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