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1. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

Author

Gumienny, Tina L., Enrico, Brugnera, Tosello-Trampont, Annie-Carole, Kinchen, Jason M., Haney, Lisa B., Nishiwaki, Kiyoji, Walk, Scott F., Nemergut, Michael E., Macara, Ian G., Francis, Ross, Schedl, Tim, Qin, Yi, Aelst, Linda Van, Hengartner, Michael O., and Ravichandran, Kodimangalam S.

Subjects
Phagocytosis -- Genetic aspects, Cell migration -- Genetic aspects, Caenorhabditis elegans -- Genetic aspects, Cell physiology -- Research, Biological sciences
Abstract

The signaling pathway genes ced-12 and elmo-1 participate in the phagocytosis and cell migration in Caenorhabditis elegans and mammals, respectively. Data indicate that CED12/ELMO-1 binds directly to CED-5/Dock180 and stimulates a Rac-GEF, which leads to Rac1 activation.

Published
2001

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