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2. Parallel infusion of hydrocortisone plusmn chlorpheniramine bolus injection to prevent acute adverse reactions to antivenom for snakebites

Author

Gawarammana, Indika Bandara, Kularatne, S Abeysingha M, Dissanayake, Wasantha P., Kumarasiri Ranjith P.V., Senanayake, Nimal, and Ariyasena, H

Subjects
Antivenins -- Research, Chlorpheniramine -- Analysis, Hydrocortisone -- Research, Hydrocortisone -- Dosage and administration, Health
Abstract

The administration of hydrocortisone as an infusion with or without a bolus of chlorpheniramine was studied that helped to prevent early adverse reactions to antivenom, as it was a common practice in Sri Lanka. It was found that hydrocortisone infusion alone was ineffective but addition of a chlorpheniramine intravenous bolus to the regimen reduced the total adverse reaction.

Published
2004

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