1. Patient level factors increase risk of acute kidney disease in hospitalized children with acute kidney injury
- Author
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Patel, Mital, Hornik, Christoph, Diamantidis, Clarissa, Selewski, David T, and Gbadegesin, Rasheed
- Subjects
Children -- Diseases ,Acute renal failure -- Diagnosis -- Complications and side effects ,Acute renal failure in children -- Risk factors -- Complications and side effects ,Health - Abstract
Background Studies in adults have shown that persistent kidney dysfunction [greater than or equal to]7-90 days following acute kidney injury (AKI), termed acute kidney disease (AKD), increases chronic kidney disease (CKD) and mortality risk. Little is known about the factors associated with the transition of AKI to AKD and the impact of AKD on outcomes in children. The aim of this study is to evaluate risk factors for progression of AKI to AKD in hospitalized children and to determine if AKD is a risk factor for CKD. Methods Retrospective cohort study of children age [less than or equal to]18 years admitted with AKI to all pediatric units at a single tertiary-care children's hospital between 2015 and 2019. Exclusion criteria included insufficient serum creatinine values to evaluate for AKD, chronic dialysis, or previous kidney transplant. Results A total of 528 children with AKI were included in the study. There were 297 (56.3%) hospitalized AKI survivors who developed AKD. Among children with AKD, 45.5% developed CKD compared to 18.7% in the group without AKD (OR 4.0, 95% CI 2.1-7.4, p-value Conclusions AKD is common among hospitalized children with AKI and multiple risk factors are associated with AKD. Children that progress from AKI to AKD are at higher risk of developing CKD. Graphical abstract, Author(s): Mital Patel [sup.1] , Christoph Hornik [sup.2] , Clarissa Diamantidis [sup.3] , David T Selewski [sup.4] , Rasheed Gbadegesin [sup.1] Author Affiliations: (1) grid.26009.3d, 0000 0004 1936 7961, Division [...]
- Published
- 2023
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