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The glycaemic and insulinaemic response to different German honey varieties have not been studied so far. Eight German honey grades differing in their floral source and carbohydrate composition were tested. Isoglucidic test meals (25 g carbohydrate) and a 25 g glucose reference were given to 10 clinically and metabolically healthy, fasting individuals (31.5 ± 8.1 years of age (mean ± s.d.), two women). Glycaemic and insulinaemic index were calculated by the recommended FAO/WHO measure. Five of the eight tested honey varieties show a low glycaemic index below 55; for six of the eight tested varieties, the glycaemic load was lower than 10 (portion size of 20 g honey). Glycaemic index and insulinaemic index correlated significantly with the fructose content of honey varieties. The results show that glycaemic index and insulinaemic response depend on the fructose content of honey. Therefore, specific honey varieties may be recommended for subjects with impaired glucose tolerance instead of saccharose in food preparations. European Journal of Clinical Nutrition (2010) 64, 762-764; doi: 10.1038/ejcn.2009.103; published online 16 September 2009 Keywords: honey;glycaemic index;homa index;insulin response, Postprandial glycaemic response has basic relevance to chronic diseases that are associated with hyperinsulinaemia and central obesity (1998). Glycaemic index (GI) is a standardized measure recommended by FAO/WHO to classify [...]