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2 results on '"Hansen, Flemming Gundorph"'

1. A short synthesis of (+)-cyclophellitol

Author

Hansen, Flemming Gundorph, Bundgaard, Eva, and Madsen, Robert

Subjects
Zinc compounds -- Chemical properties, Chemical synthesis -- Methods, Biological sciences, Chemistry
Abstract

A new synthesis of (+)-cyclophellitol a potent beta-glucosidase inhibitor that was completed in nine steps from D-xylose is described. This represents the shortest method for preparing enantiopure cyclophellitol.

Published
2005

2. 3'-C-branched LNA-type nucleosides locked in an N-type furanose ring conformation: synthesis, incorporation into oligodeoxynucleotides and hybridization studies

Author

Meldgaard, Michael, Hansen, Flemming Gundorph, and Wengel, Jesper

Subjects
Nucleosides -- Analysis, Oligomers -- Analysis, Chemical synthesis -- Analysis, Biological sciences, Chemistry
Abstract

Synthetic routes towards the three protected 3'-C-branched LNA-type phosphoramidite building blocks containing furanose rings locked in an N-type conformation starting from a known 3-C-allyl allofuranose derivative is reported. At low salt conditions a duplex stabilizing effect of introducing 3'-C-aminopropyl-LNA monomer relative to 3'-C-hydroxypropyl-LNA monomer was observed.

Published
2004

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