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2 results on '"Julenius, Karin"'

1. Fragment complementation studies of protein stabilization by hydrophobic core residues

Author

Berggard, Tord, Julenius, Karin, Ogard, Andrea, Drakenberg, Torbjorn, and Linse, Sara

Subjects
Proteins -- Structure, Amino acids -- Structure-activity relationships, Structural stability -- Analysis, Calcium-binding proteins -- Analysis, Biological sciences, Chemistry
Abstract

Research examines the role of hydrophobic core substitutions, contributed by the EF subdomain fragments, on the reconstitution and stabilization of a protein as exemplified by the calcium-binding protein calbindin D. Data show a strong correlation between the affinity and stability indicating to the importance of the hydrophobic core residues.

Published
2001

2. Hydrophobic core substitutions in calbindin D(sub 9k): effects on stability and structure

Author

Julenius, Karin, Thulin, Eva, Linse, Sara, and Finn, Bryan E.

Subjects
Calcium-binding proteins -- Analysis, Protein binding -- Analysis, Gene mutations -- Analysis, Biological sciences, Chemistry
Abstract

A study on the effect of mutations of hydrophobic amino acids on the structure and folding of calbindin D(sub 9k) is presented. Calbindin D(sub 9k) is a four-helix calcium-binding protein that does not easily undergo conformational change. Eleven mutations have been made at eight sites in the hydrophobic core of calbindin D(sub 9k). Results show that calbindin D(sub 9k) can absorb large changes in stability without any changes in its fold and calcium-binding properties.

Published
1998

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