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1. SEEING THE LIGHT: A WIFE AND HUSBAND RESEARCH TEAM CRACKS THE CODE ON GENE THERAPY WITH A NEW TREATMENT FOR BLINDNESS

2. Mounting evidence indicts fine-particle pollution: particle air pollution clearly causes substantial deaths and illness, but what makes fine particles so toxic--the size, the chemical compound, or both?

3. Sipping from a poisoned chalice: people have believed since antiquity that tiny doses of toxicants can be healthful. Now hormesis, a concept once discredited in scientific circles, is making a surprising comeback

4. Population databases boom, from Iceland to the U.S.: countries and health providers are following Iceland's path and combining health and genetic data on large populations. They promise to deliver 'personalized' medicine, but will they? (News Focus)

5. The science of Pfiesteria: elusive, subtle, and toxic: ten years after ecologists in North Carolina found evidence that a toxic microbe caused mass fish die-offs, the toxin remains unidentified and the research is being challenged. (News Focus)

7. 150th bash draws a crowd

8. Showdown over clean air science

9. Facing the big chill in science

12. A one-size-fits-all flu vaccine? The threat of avian influenza has revived efforts to develop 'universal' flu vaccines that protect against all human influenza strains. Although that goal remains elusive, vaccines that protect against seasonal flu variants could be closer

13. After regime change at the National Cancer Institute: Andrew von Eschenbach, who has been nominated to head FDA, is expected to step down soon as director of NCI after a controversial tenure. His successor will face a big budget squeeze and low morale

15. Putting the fingers on gene repair: the struggling field of gene therapy could regain its momentum if proteins called zinc finger nucleases five up to their promise of efficiently and safely repairing mutations

16. New Orleans labs start their uncertain comeback: putting on a brave face as they begin returning to their flood-ravaged city, researchers are trying to resurrect their personal lives and research careers

17. An earlier look at baby's genes: the increasing ability to analyze fetal DNA from maternal blood should lead to better prenatal diagnoses of genetic disease--and confront future parents with tough information and choices

18. Gender in the pharmacy: does it matter? Studies of how women's and men's bodies process drugs have turned up mostly minor differences. But some drugs may be less or more effective in women or cause more side effects, and other variations may await discovery

19. Has biodefense gone overboard? The 9/11 terrorist attacks and the anthrax letters triggered a vast program to protect the U.S. from bioterrorism. Three years later, some scientists complain that it is hurting basic microbiology--and ultimately, public health

20. Facing down pandemic flu, the world's defenses are weak: a lack of interest in developing pandemic flu vaccines and a dearth of antiviral drugs have left the world vulnerable to a global outbreak

21. Wounding earth's fragile skin

22. Manganese: a high-octane dispute: a debate over the health effects of airborne manganese is heating up as more and more countries begin adding the metal to gasoline. (News)

23. Breaking up is far too easy: spring is in the air on the Antarctic Peninsula, where rising temperatures are eroding ice shelves that have been in place for millennia. Their retreat could augur a far more perilous melting of the mainland ice sheets. (News)

24. Coming to grips with the world's greenhouse gasses

25. Panels lead the way on the road to Kyoto conference

26. When a habitat is not a home: many ecologists say conservation plans designed to ease tensions between landowners and environmentalists are not grounded in good science

27. Scientists go sleepless in Seattle at AAAS meeting

28. Backlash strikes at affirmative action programs

46. Bank shot

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