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1. A stereoselective three-component reaction: KAl(SO4)2.12H2O, an efficient and reusable catalyst for the one-pot synthesis of cis-isoquinolic acids

Author

Azizian, Javad, Mahammadi, Ali A., Karimi, Ali R., and Mohammadizadeh, Mohammad R.

Subjects
Catalysts -- Research, Chemical reactions -- Research, Quinoline -- Chemical properties, Biological sciences, Chemistry
Abstract

A strategy of efficient and convenient green synthesis for the preparation of tetrahydroisoquinolonic acids in three-component cyclocondensation reaction of homophthalic anhydride, aldehydes, and amines using the inexpensive, nontoxic, and easily available KAl(SO4)2.12H2O catalyst is described. This reaction is stereoselective in the preparation of cis-isoquinolonic acids.

Published
2005

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