1. How insulin engages its primary binding site on the insulin receptor
- Author
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Menting, John G., Whittaker, Jonathan, Margetts, Mai B., Whittaker, Linda J., Kong, Geoffrey K.-W., Smith, Brian J., Watson, Christopher J., Zakova, Lenka, Kletvikova, Emilia, Jiracek, Jiri, Chan, Shu Jin, Steiner, Donald F., Dodson, Guy G., Brzozowski, Andrzej M., Weiss, Michael A., Ward, Colin W., and Lawrence, Michael C.
- Subjects
Insulin -- Receptors -- Physiological aspects -- Genetic aspects -- Research ,Protein binding -- Physiological aspects -- Research ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival (1,2). Insulin resistance contributes to the pathogenesis of type 2 diabetes mellitus [...]
- Published
- 2013