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The RiboWest Conference brings together RNA researchers in Canada with the 2-fold goals of fostering internationally competitive RNA research and of training the next generation of scientists. The 14th Annual RiboWest conference (RiboWest 2018) was held at the University of Lethbridge (Lethbridge, Alberta) from June 10th to 13th, 2018. This meeting was focused on all major aspects of RNA research, ranging from understanding the cellular role of RNA, studying RNA interactions and structures, and employing them as a therapeutic tool. The invited keynote speakers (5) provided insights into the wide-range of RNA-based research. One of the unique features of this conference was that the majority of the oral presentations were given by the trainees (undergraduate/graduate students and postdoctoral researchers). Hosted by the Alberta RNA Research and Training Institute (ARRTI) at the University of Lethbridge as the leading center of RNA research in Western Canada, the RiboWest 2018 was well attended by researchers from across the country (>110 attendees in total). This conference proceedings editorial presents the overview of the conference, and briefly introduces articles published in this special issue of Biochemistry and Cell Biology. Key words: RiboWest, RNA, Western Canadian RNA Conference, University of Lethbridge. La RiboWest Conference reunit annuellement des chercheurs oeuvrant dans le domaine de l'ARN au Canada, avec le double objectifdepromouvoir une recherche sur l'ARNde calibre mondialetde former laprochaine generationde scientifiques. La [14.sup.e] RiboWest Conference (RiboWest 2018) s'est tenue a l'Universite de Lethbridge (Lethbridge, Alberta) du 10 au 13 juin 2018. Ce colloque etait consacre a tous les principaux aspects de la recherche sur l'ARN, allant de la comprehension du role des ARN dans la cellule, l'etude des interactions et des structures des ARN et leur utilisation comme outils therapeutiques. Les cinq conferenciers d'honneur ont offert un apercu de la vaste etendue de la recherche sur l'ARN. Une des particularites de ce colloque venait du fait que la majorite des presentations orales ont ete donnees par des stagiaires (etudiants de premier cycle, etudiants de cycles superieurs et chercheurs postdoctoraux). Accueilli par le Alberta RNA Research and Training Institute (ARRTI) de l'Universite de Lethbridge en sa qualite de centre de pointe de la recherche sur l'ARN dans l'Ouest canadien, la RiboWest 2018 a rassemble des chercheurs de tout le pays (>110 participants au total). Cet editorial des actes du colloque presente une vue d'ensemble du colloque et introduit brievement les articles publies dans ce numero special de la revue Biochimie et biologie cellulaire. [Traduit par la Redaction] Mots-cles : RiboWest, ARN, Western Canada RNA Conference, Universite de Lethbridge., Introduction The first RiboWest conference was held in 2005 at the University of Northern British Columbia, British Columbia, Canada, spearheading the formation of a collaborative community of RNA researchers in [...]

The crystal structures of 'Thermotoga maritima' L10 in complex with three L7/12 N-terminal-domain dimers is presented, the structure of an archael L10E N-terminal domain on the 50S subunit is refined and elements in cryo-electron-microscopic are identified in the reconstructions of 'Escherichia coli' ribosomes. The stalk is organized into three elements, the stalk base, L10 helix alpha8-L7/12 N-terminal-domain complex and L7/12 C-terminal domains, linked by flexible connections.

Rapid kinetic techniques were used to study the timing of phosphate ([P.sub.i]) release from elongation factor Tu (EF-Tu) and its implications for the functions of EF-Tu on the ribosome. Results showed that [P.sub.i] release from EF-Tu is >20-fold slower than GTP cleavage and limits the rate of the conformational switch of EF-Tu from the GTP- to the GDP-bound form.