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1. A CUC triplet confers leucine-dependent regulation of the Bacillus subtilis ilv-leu operon

Author

Marta, Peter T., Ladner, Robert D., and Grandoni, Jerry A.

Subjects
Bacillus subtilis -- Genetic aspects, Operons -- Research, Gene expression -- Research, Biological sciences
Abstract

Regulation of the ilv-leu operon in Bacillus subtilis may require the interaction of a tRNA(sub GAG) with leader region mRNA. Conversion of a CUC (Leu) triplet found within the leader region to UUC (Phe), CGC (Arg), or UAC (Tyr) converted reporter gene expression to control by corresponding amino acids. Conversion of the CUC triplet to CUU (Leu) reduced expression and halted regulation. Findings indicate that other tRNAs can substitute for tRNA(super Leu) but interactions in addition to pairing of the anticodon with the CUC triplet are essential for proper regulation.

Published
1996

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