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Technetium-99m human serum albumin (99mTc-HSA) is an important radiopharmaceutical required in nuclear medicine studies. However, the risk of transfusion-transmitted infection remains a major safety concern. Autopreparation of serum component acquired from patient provides a 'personal-exclusive' source for radiolabeling. This paper is to evaluate the practicality of onsite elusion and subsequent radiolabeling efficacy for serum albumin. Results showed that the autologous elute contained more albumin fraction than serum without extraction procedure. Good radiochemical purity and stability were demonstrated after radiolabeling. Biodistribution study showed that labeled albumin accumulated immediately in the lung, liver, and kidney. It was cleared steadily and excreted in the urine. The biologic half-life was defined, and all samples passed the pyrogenicity and sterility tests. In conclusion, autoalbumin could be extracted and radiolabeled properly in a nuclear medicine setting. Moreover, the risk of transfusion-transmitted infection associated with nonautologous, multisource [sup.99m]Tc-HSA agents can be reduced., 1. Introduction Technetium-99m-labeled human serum albumin ([sup.99m]Tc-HSA) is an important radiopharmaceutical commonly used in nuclear medical services. It is routinely used in lymphoscintigraphic studies, sentinel lymph node mapping, blood pool [...]