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1. Transcriptional activation by p53 correlates with suppression of growth but not transformation

Author

Crook, Tim, Marston, Nicola J., Sara, Elizabeth A., and Vousden, Karen H.

Subjects
Tumor suppressor genes -- Analysis, Genetic transcription -- Regulation, Genetic transformation -- Analysis, Biological sciences
Abstract

Experimental analysis of several naturally occurring and truncation tumor suppressor gene p53 mutants reveals a direct relation between p53-induced growth suppression and transcription activation. However, the mutants are capable of transactivation and transformation activities, indicating that p53 genes do not affect transformation. Cell lines containing the expression of endogenous p53 transactivating functional proteins have a high p53 transcriptional activity.

Published
1994

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