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19 results on '"Martin, Daniel F."'

1. A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis

Author

Martin, Daniel F., Sierra-Madero, Juan, Walmsley, Sharon, Wolitz, Richard A., Macey, Katherine, Georgiou, Panos, Robinson, Charles A., and Stempien, Mary Jean

Subjects
Cytomegalovirus infections -- Drug therapy, Retina -- Inflammation, Ganciclovir -- Evaluation
Abstract

Valganciclovir taken orally appears to be as effective as intravenous ganciclovir for treating cytomegalovirus infections of the retina in AIDS patients. An oral drug is always preferable to an intravenous drug, and oral valganciclovir is even preferable to oral ganciclovir.

Published
2002

2. Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant

Author

Martin, Daniel F., Kuppermann, Baruch D., Wolitz, Richard A., Palestine, Alan G., Li, Hong, and Robinson, Charles A.

Subjects
Ganciclovir -- Evaluation, Cytomegalovirus infections -- Drug therapy, Retinal diseases -- Drug therapy
Abstract

AIDS patients who receive an intraocular ganciclovir implant to treat cytomegalovirus retinitis should also take oral ganciclovir. Cytomegalovirus retinitis is a viral infection of the retina. Researchers randomly assigned 377 AIDS patients with cytomegalovirus retinitis in one eye to receive one of three treatments: an intraocular ganciclovir implant plus oral ganciclovir, an intraocular implant plus an oral placebo, or intravenous ganciclovir with no implant. Patients who received the implant plus oral ganciclovir delayed the progression of retinitis and also reduced the risk of cytomegalovirus infection in other parts of the body.

Published
1999

5. Treatment of cytomegalovirus retinitis with a sustained release ganciclovir implant

Author

Musch, David C., Martin, Daniel F., Gordon, Judy F., Davis, Matthew D., and Kuppermann, Baruch D.

Subjects
Cytomegalovirus infections -- Drug therapy, Retinal diseases -- Drug therapy, Ganciclovir -- Dosage and administration, AIDS (Disease) -- Complications
Abstract

Intraocular implants that provide a sustained release of ganciclovir appear to slow the progression of cytomegalovirus retinitis but do not prevent this infection of the retina from occurring in the other eye. Researchers randomly assigned 173 AIDS patients with cytomegalovirus retinitis to receive one of two dosages of ganciclovir implanted directly in the eye or intravenous ganciclovir. Those receiving intravenous ganciclovir had almost three times the risk of disease progression than those who had implants but they were half as likely to have the disease spread to the other eye.

Published
1997

6. Three cases of large retinal capillary hemangiomas treated with verteporfin and photodynamic therapy

Author

Aabert, Thomas M. Jr., Aabert, Thomas M. Sr., Martin, Daniel F., Gilman, James P., and Myles, Robert

Subjects
Retinal diseases -- Care and treatment, Photochemotherapy -- Research, Photochemotherapy -- Patient outcomes, Hemangioma -- Research, Hemangioma -- Case studies, Cancer -- Photochemotherapy, Cancer -- Research, Cancer -- Patient outcomes, Health, Verteporfin (Medication) -- Patient outcomes, Verteporfin (Medication) -- Research, Verteporfin (Medication) -- Dosage and administration
Published
2005

8. Identifying and eliminating the roadblocks to comparative-effectiveness research

Author

Martin, Daniel F., Maguire, Maureen G., and Fine, Stuart L.

Subjects
Government regulation, Medical care, Cost of -- Laws, regulations and rules, Macular degeneration -- Care and treatment, Macular degeneration -- Research, Patient advocacy -- Evaluation
Abstract

The Comparison of Age-Related Macular Degeneration [AMD] Treatments Trials (CATT) should be launched to identify and eliminate the important road-blocks and remarkable changes needed in federal infrastructure for comparative-effectiveness research (CER) to be conducted efficiently. A need to implement comprehensive federal policy that would cover all drug-related costs and simplify the planning and execution of CER trials is recommended.

Published
2010

9. Effects of enzymatic sterilization detergents on the corneal endothelium. (Laboratory Sciences)

Author

Parikh, Chirag, Sippy, Brian D., Martin, Daniel F., and Edelhauser, Henry F.

Subjects
Cornea, Enzymes -- Health aspects, Sterilization -- Methods, Endophthalmitis -- Prevention, Health
Abstract

Objective: To evaluate the potential of enzymatic detergents to cause endothelial damage and anterior segment inflammation. Methods: Paired rabbit corneas were mounted in an in vitro specular microscope. Endothelia were perfused either with the sterile irrigating solution BSS Plus (Alcon Laboratories Inc, Ft Worth, Tex) (control) or 0.1%, 0.4%, or 1.0% Medline Enzymatic Detergent (Medline Industries Inc, Mundelein, Ill) in BSS Plus. Swelling rates were determined by regression analysis. Human endothelia were perfused using 1.56% detergent. All corneas were fixed for scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Endothelial permeability was determined following perfusion of 0.78% detergent. Finally, in vivo intracameral injections with 1.56% or 3.9% detergent were performed to evaluate clinical changes and to correlate with histopathologic analysis. Results: Dose-related corneal swelling rates were observed. Digital specular micrographs revealed greater endothelial cell damage when perfused with 1.0% detergent. The TEM of endothelia exposed to 1.0% solutions demonstrated abnormal vacuolization and dilated extracellular spaces, which manifested as an increased corneal permeability to 3 to 4 times that of controls. Human corneas swelled comparably to rabbit corneas but demonstrated increased sensitivity when evaluated by TEM and SEM. Histopathologic analysis after intracameral injection revealed thickened corneas with fewer endothelial cells and irises with increased inflammatory and fibrinous responses compared with controls. Conclusions: Medline Enzymatic Detergent causes a dose-dependent corneal swelling, ultrastructural damage, increased corneal permeability, and increased inflammatory response in the iris after intracameral injection. Clinical Relevance: Failure to adequately rinse the detergent from surgical instruments may result in corneal edema and intraocular inflammation. Arch Ophthalmol. 2002;120:165-172

Published
2002

16. Targeted for speed, triple-bus DSP IC dispatches real numbers at 6.25 MIPS

Author

Martin, Daniel F., Mary, Luc, and Barazesh, Baradir

Subjects
Semiconductor industry, Digital signal processor, Thomson Semiconducteurs -- Product introduction, Semiconductor industry -- Product introduction, Signal processing, Bus conductors (Electricity) -- Innovations -- Product introduction
Abstract

Targeted for speed, triple-bus DSP IC dispatches real numbers at 6.25 MIPS Though Harvard architectures and short cycle times are common in digital signal processors, they are not particularly rare […]

Published
1986

18. Treatment of cytomegalovirus retinitis with an intraocular sustained-release ganciclovir implant: a randomized controlled clinical trial

Author

Martin, Daniel F.

Subjects
Ganciclovir -- Dosage and administration, Cytomegalovirus infections -- Drug therapy, Retinal diseases -- Drug therapy, Controlled release preparations -- Evaluation
Abstract

Background and Methods: We performed a randomized controlled clinical trial to assess the safety and efficacy of a 1 [mu]g/h ganciclovir implant for the treatment of newly diagnosed cytomegalovirus (CMV) retinitis in patients with the acquired immunodeficiency syndrome (AIDS). Patients with previously untreated peripheral CMV retinitis were randomly assigne(i either to immediate treatment with the ganciclovir implant or to deferred treatment. Standardized fundus photographs were taken at 2-week intervals and analyze(i in a masked faswon. The study end point was progression of retinitis based on the photographic assessment. Results: Twenty-six patients (30 eyes) were enrolled. The median time to progression of retinitis was 15 days in the defferred treatment group (n=16) vs 226 days in the immediate treatment group (n=14) (P

Published
1995

19. Use of the Ganciclovir Implant for the Treatment of Cytomegalovirus Retinitis in the Era of Potent Antiretroviral Therapy: Recommendations of the International AIDS Society-USA Panel

Author

MARTIN, DANIEL F., DUNN, JAMES P., DAVIS, JANET L., DUKER, JAY S., ENGSTROM, ROBERT E. JR, FRIEDBERG, DOROTHY N., JAFFE, GLENN J., KUPPERMANN, BARUCH D., POLIS, MICHAEL A., WHITLEY, RICHARD J., WOLITZ, RICHARD A., and BENSON, CONSTANCE A.

Subjects
Cytomegalovirus infections -- Drug therapy, Retinal diseases -- Drug therapy, Ganciclovir -- Evaluation, Health
Published
1999

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