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Original citation: J Clin Invest. 2020;130(1):335-344. https://doi.org/10.1172/JCI129937. Citation for this corrigendum: J Clin Invest. 2022;132(11):e161852. https://doi.org/10.1172/JCI161852. The authors recently became aware that the standard errors for the diabetes group were [...]

Background The most frequently mutated gene of steroid-resistant nephrotic syndrome (SRNS) is NPHS2. Current guidelines propose the sequencing of all NPHS2 exons only in childhood-onset SRNS. Methods A cohort of 38 Hungarian patients with childhood-onset nephrotic-range proteinuria was screened for NPHS2 mutations. The frequency of the p.V290M mutation in late-onset SRNS was examined in the French and PodoNet cohorts. Results Of the 38 Hungarian patients screened, seven carried NPHS2 mutations on both alleles, of whom two--diagnosed with proteinuria through school screening programs at the age of 9.7 and 14 years, respectively--did not develop nephrotic syndrome in childhood. The first, an 18-year-old boy, homozygous for p.V290M, has never developed edema. The second, a 31-year-old woman--compound heterozygous for p.V290M and p.R138Q--was first detected with hypoalbuminemia ( Conclusions We propose that not only the p.R229Q variant, but also the p.V290M mutation should be screened in Central and Eastern European patients with late-onset SRNS. Keywords Genetics * Nephrotic syndrome * NPHS2 * Podocin * Mutation screening * Algorithm, Introduction Nephrotic syndrome is the consequence of damage to the glomerular filtration barrier and refers to a clinical picture of heavy proteinuria, hypoalbuminemia, edema and hyperlipidemia. The majority of patients [...]