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The current research proposes an integrated framework for product design that incorporates simulation-based tools into the early design stage to achieve optimum multiscale systems. The method to determine the appropriate cellular material-property relations for the internal material structures of the system is through a topology optimization technique and a multiscale design process. Specifically, the reliability-based topology optimization (RBTO) and a multi-attribute decision design method are integrated into the inductive design exploration method (IDEM). The RBTO method is introduced to determine optimal topologies at the mesoscale. The multi-attribute decision design method is used for decision support in the design process of the macroscale systems. IDEM offers the capability for concurrent design on multiple scales providing an approach for the integration of the other two methods. An example of the developed multiscale design framework is presented in terms of a hydrogen storage tank used in a hydrogen fuel cell for automotive applications. The multiscale tank design will feature a high strength cellular structured wall, resulting in a large weight reduction. [DOI: 10.1115/1.4002294]