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Your search keyword '"Schlossman, S.F."' showing total 2 results
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2 results on '"Schlossman, S.F."'

1. Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clusters

Author

Stuhler, G., Sobywalski, A., Grunebach, F., Brossart, P., Reichardt, V.L., Barth, H., Stevanovic, S., Brugger, W., Kanz, L., and Schlossman, S.F.

Subjects
T cells -- Differentiation, Dendrites -- Research, Science and technology
Abstract

Help for the induction of cytolytic T lymphocytes is mediated by dendritic cells (DC) that are conditioned by CD40 signaling. We identified tumor necrosis factor family member CD27L/CD70, which is expressed by cytolytic T lymphocytes on interaction with DC to control CD154 (CD40L) up-regulation on CD45R[A.sup.+] helper T cells for subsequent DC stimulation. The results show that the initiation of a cytolytic immune response is determined by regulatory circuits, requiring simultaneous activation and differentiation of all cells involved in T lymphocyte-DC cluster formation.

Published
1999

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