1. Avoid being trapped by your liver: ischemia-reperfusion injury in liver transplant triggers SIP-mediated NETosis
- Author
-
Scozzi, Davide and Gelman, Andrew E.
- Subjects
Health care industry - Abstract
Liver transplantation can be a life-saving treatment for end-stage hepatic disease. Unfortunately, some recipients develop ischemia-reperfusion injury (IRI) that leads to poor short- and long-term outcomes. Recent work has shown neutrophils contribute to IRI by undergoing NETosis, a form of death characterized by DNA ejection resulting in inflammatory extracellular traps. In this issue of the JCI, Hirao and Kojima et al. report that sphingosine-1-phosphate (S1P) expression induced by liver transplant-mediated IRI triggers NETosis. They also provide evidence that neutrophil expression of the carcinoembryonic antigen-related cell adhesion molecule-1 (CC1) long isoform inhibited NETosis by controlling S1P receptor-mediated autophagic flux. These findings suggest stimulating regulatory mechanisms that suppress NETosis could be used to prevent IRI., CC1-L restrains IRI and NETosis Liver transplantation remains the only life-saving option for patients with end-stage hepatic disease. A common postoperative complication, ischemia-reperfusion injury (IRI), is the predominant driver of [...]
- Published
- 2023
- Full Text
- View/download PDF