1. Structure-activity analysis of the Pseudomonas quinolone signal molecule
- Author
-
Hodgkinson, James, Bowden, Steven D., Galloway, Warren R.J.D., Spring, David R., and Welch, Martin
- Subjects
Quinolones -- Physiological aspects ,Quinolones -- Genetic aspects ,Pseudomonas -- Physiological aspects ,Genetic transcription -- Physiological aspects ,Bacterial genetics -- Research ,Biological sciences - Abstract
We synthesized a range of PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone) analogues and tested them for their ability to stimulate MvfR-dependent pqsA transcription, MvfR-independent pyoverdine production, and membrane vesicle production. The structure-activity profile of the PQS analogues was different for each of these phenotypes. Certain inactive PQS analogues were also found to strongly synergize PQS-dependent pyoverdine production. doi: 10.1128/JB.00081-10
- Published
- 2010