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1. Improved gene correction efficiency with a tailed duplex DNA fragment

Author

Tsuchiya, Hiroyuki, Uchiyama, Masayuki, Hara, Kazuhiro, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Inoue, Hideo, Harashima, Hideyoshi, and Kamiya, Hiroyuki

Subjects
Annealing -- Analysis, DNA -- Structure, DNA -- Chemical properties, Nucleotides -- Chemical properties, Biological sciences, Chemistry
Abstract

The studies of the annealing of a helper oligonucleotide to an ss DNA fragment that enhanced gene correction is reported. The results revealed that gene correction using tailed ds DNA fragments could be used as an efficient method for personalized medicine based on an individual's genetic information.

Published
2008

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