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1. Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d] isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies

Author

Castellano, Sabrina, Tamborini, Lucia, Viviano, Monica, Pinto, Andrea, Sbardella, Gianluca, and Conti, Paola

Subjects
Benzene -- Structure, Benzene -- Chemical properties, Ring formation (Chemistry) -- Analysis, Microwaves -- Usage, Pyrrole -- Structure, Pyrrole -- Chemical properties, Biological sciences, Chemistry
Abstract

Two modern synthetic technologies are compared that have performed 1,3-dipolar cycloaddition reactions, The studies have shown the power of microwave-assisted and flow-based methods when compared to the conventional one in terms of reaction time and yield, and have shown the potential of flow chemistry in terms of time, automation and scaling up opportunities.

Published
2010

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